CAS: 171596-44-4; Methyl (1R,3S)-1-(Benzo[d][1,3]Dioxol-5-yl)-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole-3-Carboxylate

上下游产品

piperonal L-tryptophan methyl ester (S)-tryptophan methyl ester hydr°Chloride D-Tryptophan methyl ester (1R,3S)-1-benzo[1,3]dioxol-5-yl-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester (6R,12aS)-6-(benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione (6R,12aS)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione

📜胡椒醇置于manganese(Iv) Oxide体系中,用 二氯甲烷,异丙醇 用作溶剂,化学反应 40.0H,反应生成(1R,3S)-1,2,3,4-四氢-1-(3,4-亚甲二氧基苯基)-9H-吡啶并[3,4-B]吲哚-3-羧酸甲酯盐酸盐他达那非杂质
参考文献:3,4-亚甲二氧基苯基取代四氢-β-咔啉哌嗪二 酮类衍生物及其用途
标题:3,4-亚甲二氧基苯基取代四氢-β-咔啉哌嗪二 酮类衍生物及其用途
摘要:本发明涉及一种3,4‑亚甲二氧基苯基取代四氢‑β‑咔啉哌嗪二酮类衍生物及其用途.具体地,本发明公开了式i所示的化合物或其立体异构体,或其药学上可接受的盐,各基团的定义详见说明书.本发明的化合物具有乙酰胆碱酯酶和磷酸二酯酶5的双重抑制活性,具有非常好的血脑屏障透过率.因此,本发明化合物可用于制备治疗和/或预防阿尔茨海默病药物.

专利信息

专利号:RU-2142463-C1
优先权日:1994-01-21
标题 :Tetracyclic derivatives, method of their synthesis (variants), pharmaceutical composition containing thereof and their use in therapy