CAS: 1522-92-5; 3-Bromo-2,2-Bis(Bromomethyl)Propanol

相似化合物

3580-97-0 52813-48-6 3296-90-0

欧盟法规

[欧盟候选物质清单

上下游产品

二溴新戊二醇 2,2-Bis(Bromomethyl)-1,3-Propanediol 3296-90-0

📜季戊四醇置于硫酸,氢溴酸,溶剂黄146体系中,化学反应 48.0H,以49%的收率获得三溴新戊醇
参考文献:通过在单个氨基酸位点引入正电荷来改变枯草杆菌蛋白酶枯草芽孢杆菌的特异性.
标题:通过在单个氨基酸位点引入正电荷来改变枯草杆菌蛋白酶枯草芽孢杆菌的特异性.
摘要:在定点诱变和化学修饰相结合的策略中,使用甲硫代磺酸盐作为硫醇特异性修饰试剂,几乎可以创造出新的蛋白质表面环境.由于我们有兴趣将静电操作作为一种调节酶活性和特异性的手段,因此我们最近采用了这种方法,以在代表性的丝氨酸蛋白酶枯草杆菌枯草芽孢杆菌(sbl)中的单个位点控制多个负电荷的掺入.现在我们描述使用这种策略引入多个正电荷.合成了一系列的甲硫磺酸单,二和三铵,并用于修饰s2位点62,S1位点156和166,S1'位点217的sbl的半胱氨酸突变体.这些化学修饰的突变体(cmm)酶的动力学参数在ph 8.6下确定.在sbl的s1,S1'和s2亚位中最多存在三个正电荷会导致活性降低多达77倍,这可能是由于干扰了催化水解反应过渡态中形成的组氨酸离子.
Doi:10.1016/s0968-0896(99)00168-6

专利信息

专利号:US-7601774-B2
优先权日:2004-07-19
标题:Synthesis of aromatic polyhalogenated halomethyl compounds
发明人：KORNBERG NURIT; ADDA MICHAEL; PELED MICHAEL
权利人:BROMINE COMPOUNDS LTD
摘要:The present invention discloses a process for the preparation of highly pure pentabromobenzyl bromide, PBB-Br, wherein the benzylic bromination reaction is carried out in a suitable organic solvent in the presence of water and wherein the reaction temperature is such that it is sufficient to activate the initiator but not high enough to consume a substantial amount thereof.

专利号:US-5135737-A
优先权日:1986-11-10
标 题:Amplifier molecules for enhancement of diagnosis and therapy
发明人：KEANA JOHN F W
权利人:OREGON STATE
摘要:Disclosed are amplifier molecules: various organic compounds having branched structures terminating with amine groups to which pharmacologically active groups can be chemically attached. A number of MRI contrast-enhancing agents were synthesized, each comprising plural active groups, such as stable nitroxides and complexes of trivalent metal cations. Such syntheses were successfully performed using a number of amplifiers having different branched structures, demonstrating the general utility of the pertinent chemistry in the synthesis of amplifiers having any of a wide variety of pharmacologically active groups. Amplifiers were also synthesized having linkers terminating with chemically reactive groups such as isothiocyanates, which render the amplifier bifunctional: attachable to polymers, biomacromolecules, or other biocompatible entity possessing multiple reactive sites such as terminal amines. Via such chemistry, the amplifiers are attachable to monoclonal antibodies for concentration of pharmacologically active groups at a desired site in the body.

专利号:WO-9403593-A1
优先权日:1992-08-04
标题 :Amplifier molecules for enhancement of diagnosis and therapy
发明人：KEANA JOHN F W
权利人:OREGON STATE
摘要:Disclosed are amplifier molecules: various organic compounds having branched structures terminating with amine groups to which pharmacologically active groups can be chemically attached. A number of MRI contrast-enhancing agents were synthesized, each comprising plural active groups, such as stable nitroxides and complexes of trivalent metal cations. Such syntheses were successfully performed using a number of amplifiers having different branched structures, demonstrating the general utility of the pertinent chemistry in the synthesis of amplifiers having any of a wide variety of pharmacologically active groups. Amplifiers were also synthesized having linkers terminating with chemically reactive groups such as isothiocyanates, which render the amplifier bifunctional: attachable to polymers, biomacromolecules, or other biocompatible entity possessing multiple reactive sites such as terminal amines. Via such chemistry, the amplifiers are attachable to monoclonal antibodies for concentration of pharmacologically active groups at a desired site in the body.

专利号:US-5412148-A
优先权日:1986-11-10
标题:Amplifier molecules derived from diethylene triaminepentaacetic acid for enhancement of diagnosis and therapy
发明人：KEANA JOHN F W
权利人:OREGON STATE
摘要:Disclosed are amplifier molecules: various organic compounds having branched structures terminating with amine groups to which pharmacologically active groups can be chemically attached. A number of MRI contrast-enhancing agents were synthesized, each comprising plural active groups, such as stable nitroxides and complexes of trivalent metal cations. Such syntheses were successfully performed using a number of amplifiers having different branched structures, demonstrating the general utility of the pertinent chemistry in the synthesis of amplifiers having any of a wide variety of pharmacologically active groups. Amplifiers were also synthesized having linkers terminating with chemically reactive groups such as isothiocyanates, which render the amplifier bifunctional: attachable to polymers, biomacromolecules, or other biocompatible entity possessing multiple reactive sites such as terminal amines. Via such chemistry, the amplifiers are attachable to monoclonal antibodies for concentration of pharmacologically active groups at a desired site in the body.

专利号:EP-1141062-B1
优先权日:1998-11-12
标题:Synthesis of energetic thermoplastic elastomers containing oligomeric urethane linkages
发明人：SANDERSON ANDREW JOHN; EDWARDS WAYNE
权利人:ALLIANT TECHSYSTEMS INC
摘要:This thermoplastic elastomer is present in a substantially solid state suitable for use as a binder for a propellant, explosive, and/or gas generant of a supplemental restraint system. The thermoplastic elastomer is formed from a composition including A blocks which are crystalline at temperatures below about 75°C and B blocks which are amorphous at temperatures above about -20°C. The A blocks are derived from oxetane derivatives and/or tetrahydrofuran derivatives. The B blocks are derived from oxetanes, tetrahydrofuran, oxiranes, and derivatives thereof. The A and B blocks are end-capped with at least one diisocyanate and linked with at least one difunctional oligomer having two functional groups which are reactive with free and unreacted isocyanate moieties of the diisocyanate.

专利号:US-6997997-B1
优先权日:1998-11-12
标 题 :Method for the synthesis of energetic thermoplastic elastomers in non-halogenated solvents
发明人：SANDERSON ANDREW J; EDWARDS WAYNE W
权利人:ALLIANT TECHSYSTEMS INC
摘要:A method is provided for preparing thermoplastic elastomers. A blocks of the thermoplastic elastomers are crystalline at temperatures below about 60° C. and are derived from oxetane derivatives and/or tetrahydrofuran derivatives. B blocks of the thermoplastic elastomer are amorphous above about −20° C. and are derived from oxetanes, tetrahydrofuran, oxiranes, and derivatives thereof. According to this method, the A and B blocks are dissolved into solution containing a non-halogenated solvent, preferably tetrahydrofuran, then dried by azeotropic distillation. The dried blocks are end-capped with a diisocyanate, preferably a diisocyanate having one isocyanate moiety substantially more reactive with the terminal groups of the blocks than the other isocyanate moiety of the diisocyanate. The end-capped blocks are then linked together with a linking compound.