专利号:US-4910330-A 优先权日:1987-09-25 标题 :Synthesis of sulfonic acids and carboxylic acid ester derivatives thereof 发明人:MCGEE DENNIS E; HALLEN TED S 权利人:UNION OIL CO 摘要:Hydroxy sulfonic acids in general and isethionic acid (2-hydroxy ethyl sulfonic acid) in particular can be prepared at 99+% purity and good yields by the selective oxidation of a precursor hydroxy mercaptan with hydrogen peroxide. The resulting product is pure enough to be used directly in the synthesis of sulfo-acrylic esters which are finding considerable use as stabilizers in producing vinylidene chloride copolymers used for FDA approved packaging films.
专利号:US-4987250-A 优先权日:1987-09-25 标 题:Synthesis of hydroxy sulfonic acids 发明人:MCGEE DENNIS E; HALLEN TED S 权利人:UNION OIL CO 摘要:Hydroxy sulfonic acids in general and isethionic acid (2-hydroxy ethyl sulfonic acid) in particular can be prepared at 99+% purity and good yields by the selective oxidation of a precursor hydroxy mercaptan with hydrogen peroxide. The resulting product is pure enough to be used directly in the synthesis of sulfo-acrylic esters which are finding considerable use as stabilizers in producing vinylidene chloride copolymers used for FDA approved packaging films.
专利号:WO-2023227996-A1 优先权日:2022-05-24 标题 :A deuterated amine compounds and process for synthesis thereof 发明人:AMBATI VIJAY; KOTHARI MANISH; JONNALAGADDA NAGASIVARAO; ALETI RANJITH; KANDASAMY DR SAKHTIVEL; ROHIT CHITTALURI KRISHNA; REDDY KATUKURI MALLIKHARJUNA 权利人:CLEARSYNTH LABS LTD 摘要:The present invention relates to a process for synthesis of a deuterated compound. Most particularly, it relates to synthesis of a deuterated amine compounds of formula (l) and salts thereof. The said compound is an important key intermediate in the synthesis of deuterated drugs and/or chemical compounds.
专利号:US-7781583-B2 优先权日:2006-09-08 标题:Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d] pryimidin-7-ones 发明人:ERDMAN DAVID THOMAS; FLAMME CATHLIN MARIE; NELSON JADE DOUGLAS 权利人:PFIZER 摘要:The present invention provides methods of preparing substituted 2-(pyridin-2-ylamino)-pirido[2,3-d]pyrimidin-7-ones (formula 1), n nuseful in treating cell proliferative disorders, or a pharmaceutically acceptable salt thereof.
专利号:WO-2021250635-A1 优先权日:2020-06-11 标题:Acid salts of fluoroquinolone carboxylic acid based compositions and methods of making and using the same 发明人:GHOSH SUMANA; BHATTACHARYYA ANAMIKA; SINGH HIMANSHI; SADHASIVAM SURESH; SINHA MAU; GARG MUKESH KUMAR; GARKHAL KALPNA; KUMAR MUKESH; KHARE PRAGATI; GUPTA SWATI; SENGUPTA SHILADITYA; CHAVDARIAN CHARLES G 权利人:VYOME THERAPEUTICS INC 摘要:The present disclosure is in the field of pharmaceutical and chemical sciences. The present disclosure generally relates to the synthesis of therapeutic agents, processes for preparing said agents, compositions comprising said therapeutic agents and their uses. In particular, the disclosure relates to medicinally important acid salts of fluoroquinolone carboxylic acid based chemical molecules [compounds of formula (I)], method of preparing said molecules, compositions thereof, and the use of such molecules as therapeutic agents. The said acid salts of fluoroquinolone carboxylic acid based chemical molecules are useful in treating infections such as ear infections, otitis, otitis media including acute otitis media, recurrent otitis media, otitis media with effusion, chronic otitis media, chronic suppurative otitis media, otitis externa (including acute otitis externa, chronic otitis externa), otitis interna and combinations thereof.
专利号:US-4828849-A 优先权日:1988-01-14 标题 :Surfactant inhibition of dental plaque 发明人:LYNCH DONALD M; APPELBAUM BENJAMIN 权利人:WARNER LAMBERT CO 摘要:The invention provides an oral preparation or composition such as a mouthwash, mouthrinse, toothpaste and the like containing certain classes of surfactants which act to inhibit plaque formation by inhibiting the initial adherence of bacteria to the dentin surfaces and in the case of one class of surfactants additionally inhibiting the glucosyl transferase catalysis to prevent the synthesis of extracellular polysaccharides from sucrose. n The surfactants comprise substituted taurines, substituted isethionates and substituted hydroxy sultaines in which the substituents are long chain hydrocarbon radicals. The surfactants are employed in the aqueous-based oral compositions at concentrations between about 0.00001M to 0.1M to effect inhibition.
1: Boroujerdi AF, Lee PA, DiTullio GR, Janech MG, Vied SB, Bearden DW. Identification of isethionic acid and other small molecule metabolites of Fragilariopsis cylindrus with nuclear magnetic resonance. Anal Bioanal Chem. 2012 Aug;404(3):777-84. doi: 10.1007/s00216-012-6169-2. Epub 2012 Jul 8. doi: 10.3390/molecules15085369.
合成参考文献
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