CAS: 1057216-55-3; 2-Chloro-5-Iodopyrazine
该化合物是一种杂交有机化合物,其特点是,在丙烯环上存在氯和碘替代物,这是一个由六人组成的芳香环,内含两个氮原子.该化合物通常呈现黄色至褐色的青色外观,在有机溶剂中可溶解.其分子结构有助于其活性,使其在各种化学合成中有用,特别是在制药和农用化学的开发中.卤素,如氯和碘,加强其电子生物特性,使其得以参与核生殖替代反应.此外,2-氯-5-碘可展示生物活动,可在药用化学中加以探讨.安全数据表明,与许多卤化化合物一样,应对该物质应谨慎处理潜在的毒性和环境关切.适当的储存和处置方法对于减少其使用的风险至关重要.
- 英文名称2-Chloro-5-Iodopyrazine
- 中文名称2-氯-5-碘吡嗪
- IUPAC名称2-chloro-5-iodopyrazine
- 其它别名2-Chloro-5-Iodopyrazine; Vgyrhyfutyyehq-Uhfffaoysa-N
- CAS编号1057216-55-3
- MFCD编号:MFCD09909701
- EINECS号:833-163-9
- 分子式:C4H2ClIN2分子量:240.43
- 产品CID: 97994
- 产品分类有机原料→分子砌块→芳杂环类化合物→吡嗪类化合物
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MSDS等安全信息
欧盟法规
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CAS号19745-07-4 2,5-二氯吡嗪 | CAS号84445-51-2 2-氯-5-(1-哌嗪基)吡嗪合成工艺路线路线简述
📜2,5-二氯吡嗪置于氢碘酸,Sodium Iodide,Sodium Hydroxide体系中,用 水 用作溶剂,化学反应生成2-氯-5-碘吡嗪
参考文献:Aryl Sulfonamide And Sulfonyl Compounds As Modulators Of Ppar And Methods Of Treating Metabolic Disorders
标题:Aryl Sulfonamide And Sulfonyl Compounds As Modulators Of Ppar And Methods Of Treating Metabolic Disorders
摘要:芳基磺酰胺和磺酰基化合物作为过氧化物酶体增殖激活受体的调节剂,包含它们的药物组合物,以及使用它们治疗疾病的方法被披露.
专利信息
专利号:US-2024239799-A1
优先权日:2021-04-02
标 题:(s)-1-(5-((pyridin-3-yl)thio)pyrazin-2-yl)-4'h,6'h-spiro[piperidine-4,5'-pyrrolo [1,2-b]pyrazol]-4'-amine derivatives and similar compounds as shp2 inhibitors for the treatment of e.g. cancer
发明人：DI FABIO ROMANO; MONTALBETTI CHRISTIAN; PETROCCHI ALESSIA; GRILLO ALESSANDRO; RANDAZZO PIETRO; ROSSETTI ILARIA; CIAMMAICHELLA ALINA
权利人:C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING; IRBM S P A
摘要:The present invention relates to compounds of formula (I). The compounds of the formula (I) are e.g. (S)-1-(5-((pyridin-3-yl)thio) pyrazin-2-yl)-41H,6′H-spiro[piperidine-4,5′-pyrrolo[1,2-b]pyrazol]-41-amine derivatives and similar compounds. The present invention also relates to the compounds of formula (I) for use as Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitors in methods of treatment of e.g. cancer, cardiovascular diseases, immunological disorders, autoimmune disorders, fibrosis, ocular disorders, systemic lupus erythematosus, diabetes, neutropenia, and combinations thereof. The present invention also relates to pharmaceutical compositions containing said compounds and to their methods of synthesis.
专利号:WO-2024068976-A1
优先权日:2022-09-29
标 题 :Azole derivatives as shp2 inhibitors
发明人：PETROCCHI ALESSIA; MONTALBETTI CHRISTIAN; DI FABIO ROMANO; CIAMMAICHELLA ALINA; ROSSETTI ILARIA
权利人:IRBM S P A; C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING
摘要:The present invention relates to new compounds capable of inhibiting the activity of SHP2 phosphatase. Compounds of the invention can be used for the treatment of disorders associated with SHP2 deregulation. The present invention also relates to pharmaceutical compositions containing said compounds and to their method of synthesis.
