CAS: 88431-47-4; Clomifenecitrate

相似化合物

124083-14-3 2001207-98-1 2024359-30-4

专利信息

专利号:US-5614551-A
优先权日:1994-01-24
标题:Inhibitors of fatty acid synthesis as antimicrobial agents
发明人：DICK JAMES D; KUHAJDA FRANCIS P
权利人:UNIV JOHNS HOPKINS
摘要:Fatty acid synthase (FAS) is overexpressed by certain infectious organisms that are resistant to most currently available antibiotics. Contrarywise, little FAS expression is identified in patient tissues. Inhibition of fatty acid synthesis is thus selectively toxic to invasive cells, while patient cells with low FAS activity are resistant. This invention provides a method of treating septic patients where fatty acid synthesis by invading cells is inhibited with resultant interruption of the disease process.

专利号:US-2013224318-A1
优先权日:2012-02-29
标 题 :Use of CPT-1 Modulators and Compositions Thereof
发明人：HWANG CHENG S; YIM SUNGHAN; SANTHANAM UMA; LYGA JOHN W
权利人:AVON PROD INC; AVON PROD INC
摘要:The present invention describes methods for improving the appearance of skin, particularly, treating, ameliorating, preventing, delaying, and/or improving one or more signs of excess accumulation and/or production of subcutaneous fat, such as cellulite, and conditions related thereto, by topically applying compositions comprising Carnitine Palmitoyl Transferase-1 (CPT-1) modulators, optionally with other anti-lipid agents; and also describes compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating loss of subcutaneous fat in the skin, wherein the compositions include natural plant constituents that stimulate lipid synthesis.

专利号:EP-0651636-B1
优先权日:1992-07-24
标 题 :Chemotherapy for cancer
发明人：KUHAJDA FRANCIS P; PASTERNACK GARY R
权利人:UNIV JOHNS HOPKINS
摘要:Fatty acid synthase (FAS) is overexpressed in carcinomas with poor prognosis, but little FAS expression is identified in normal tissues. Inhibition of fatty acid synthesis is selectively toxic to carcinoma cells, while normal cells with low FAS activity are resistant. This invention provides a method of treating cancer patients where fatty acid synthesis by cells of the patient's tumor is inhibited with resultant interruption of the disease process.