CAS: 88192-19-2; 3-Azidopropylamine

该化合物是一种有机化合物,其特征是附于丙型-1胺脊柱的Azide功能组(-N3),该化合物具有三碳链,一端为氨基组(-NH2),第二碳为氮基组.该化合物一般无色可粉黄黄色液体或固态,视其纯度和形态而定.Azide组因其反应性而闻名,特别是点击化学和作为各种含氮化合物的前体. 3-Azidopropan-1-Amina经常用于合成有机化学,以便将的功能引入其他分子,促进进一步的转化.重要的是,要谨慎处理该化合物,因为有与化物有关的潜在危险,包括某些条件下的爆炸性质.此外,它具有极地溶剂的溶解性,能够适应各种化学反应.与所有化学品一样,在与3-azidoprapan-1-Amin合作时,应当遵循适当的安全议定书.

结构式图片

相似化合物

129392-84-3 88192-20-5 148759-41-5

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号6276-54-6 3-氯丙胺盐酸盐 | CAS号5003-71-4 3-溴丙胺氢溴酸盐 | CAS号14753-26-5 3-氯丙胺 | CAS号100910-72-3 1,3-diazidopropane | CAS号18370-81-5 3-Bromopropylamine | CAS号603-35-0 三苯基膦 | CAS号67-56-1 甲醇 | CAS号41236-20-8 3-bromopropan-1... | CAS号177489-73-5 1-azido-3-is°Cy... | CAS号861535-91-3 Carbamic acid,(... | CAS号10517-44-9 1,3-二氨基丙烷二盐酸盐 (低含水量) | CAS号109-76-2 1,3-丙二胺 | CAS号34987-20-7 N-(3-aminopropy... | CAS号83708-45-6 N-phenylpropane... | CAS号610794-21-3 N-(3-azidopropy... | CAS号6108-74-3 Benzamide,N-(3-... | CAS号510758-33-5 5-(3-azidopropy...

合成工艺路线路线简述

  • 100910-72-3 = 88192-19-2
    反应条件:1.1 Reagents: Triphenylphosphine,Hydrochloric Acid Solvents: Diethyl Ether,Ethyl Acetate
    标题:An Efficient And Practical Method For The Synthesis Of Mono-N-Protected α,ω-Diaminoalkanes
    作者:Lee,J. W.; Et Al
    参考文献:Tetrahedron Letters 日期:2001 卷标:42(14) 页码:2709-2711]

    100910-72-3 = 88192-19-2
    反应条件:1.1 Reagents: Triphenylphosphine,Hydrochloric Acid Solvents: Diethyl Ether,Ethyl Acetate,Water; 1 H,0 °C; 16 H,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 12,Rt
    标题:Synthesis And Biological Evaluation Of Hybrid Acridine-Hsp90 Ligand Conjugates As Telomerase Inhibitors
    作者:Roe,S.; Et Al
    参考文献:Organic & Biomolecular Chemistry 日期:2015 卷标:13(31) 页码:8500-8504]

    129392-84-3 = 88192-19-2
    反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane; 1 H,Rt
    标题:Facile Functionalization Of Fk506 For Biological Studies By The Thiol-Ene 'Click' Reaction
    作者:Guo,Zhi-Fo; Et Al
    参考文献:Rsc Advances 日期:2014 卷标:4(22) 页码:11400-11403]

    6276-54-6 = 88192-19-2
    反应条件:1.1 Reagents: Sodium Azide Solvents: Water; 15 H,Rt -> 80 °C1.2 Reagents: Potassium Hydroxide; Basified
    标题:Synthesis And Application Of A New Cleavable Linker For "Click"-Based Affinity Chromatography
    作者:Landi,Felicetta; Et Al
    参考文献:Organic & Biomolecular Chemistry 日期:2010 卷标:8(1) 页码:56-59]

    5003-71-4 = 88192-19-2
    反应条件:1.1 Reagents: Sodium Azide Solvents: Water; 16 H,Reflux
    标题:Synthesis Of The 5,6-Dihydroxymorpholin-3-One Fragment Of Monanchocidin A
    作者:Shi,Yunlong; Et Al
    参考文献:Organic Letters 日期:2015 卷标:17(4) 页码:968-971]

    177489-73-5 = 88192-19-2
    反应条件:1.1 Solvents: Tetrahydrofuran
    标题:Curtius Rearrangement Of ω-Azido Acid Chlorides: Access To The Corresponding ω-Azido Substituted Amines And Carbamates,Useful Building Blocks For Polyamine Syntheses
    作者:Khoukhi,Mostafa; Et Al
    参考文献:Synthesis 日期:1996 卷标:(4) 页码:483-7]

    18370-81-5 = 88192-19-2
    反应条件:1.1 Reagents: Lithium Azide Solvents: Water; 10 Min,Rt; 12 H,80 °C
    标题:Coupling Protein Engineering With Probe Design To Inhibit And Image Matrix Metalloproteinases With Controlled Specificity
    作者:Morell,Montse; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2013 卷标:135(24) 页码:9139-9148]

    18370-81-5 = 88192-19-2
    反应条件:1.1 Reagents: Sodium Azide Solvents: Water; 19 H,80 °C; 80 °C -> Rt1.2 Reagents: Potassium Hydroxide; Rt
    标题:Synthesis Of Substituted Imidazolines By An Ugi/staudinger/aza-Wittig Sequence
    作者:Welsch,Sebastian J.; Et Al
    参考文献:Tetrahedron Letters 日期:2015 卷标:56(8) 页码:1025-1029]

    1534344-80-3 = 88192-19-2
    反应条件:1.1 Reagents: Sodium Azide Solvents: Dimethylformamide; 90 °C
    标题:A Mild Removal Of Fmoc Group Using Sodium Azide
    作者:Chen,Chun-Chi; Et Al
    参考文献:Amino Acids 日期:2014 卷标:46(2) 页码:367-374]

    6266-35-9 = 88192-19-2
    反应条件:1.1 Reagents: Sodium Azide
    标题:Rapid Synthesis Of Functionalized High-Generation Polyester Dendrimers Via Strain-Promoted Alkyne-Azide Cycloaddition
    作者:Mcnelles,Stuart A.; Et Al
    参考文献:Macromolecules (Washington 日期:2017 卷标:50(20) 页码:7993-8001]

    58885-58-8 = 88192-19-2
    反应条件:1.1 Reagents: Triethylamine,Methanesulfonyl Chloride Solvents: Dichloromethane; 0 °C1.2 Reagents: Sodium Azide Solvents: Acetonitrile; Heated1.3 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane; Rt
    标题:Nanososg: A Nanostructured Fluorescent Probe For The Detection Of Intracellular Singlet Oxygen
    作者:Ruiz-Gonzalez,Ruben; Et Al
    参考文献:Angewandte Chemie 日期:2017 卷标:56(11) 页码:2885-2888]

    70017-54-8 = 88192-19-2
    反应条件:1.1 Reagents: Potassium Hydroxide; 1.5 H,10 °C
    标题:Water-Borne Nanocoating For Rapid Inactivation Of Sars-Cov-2 And Other Viruses
    作者:Bobrin,Valentin A.; Et Al
    参考文献:Acs Nano 日期:2021 卷标:15(9) 页码:14915-14927]

    88192-21-6 = 88192-19-2
    反应条件:1.1 Reagents: Hydrazine Solvents: Ethanol; 36 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified,Rt1.3 Reagents: Potassium Hydroxide Solvents: Chloroform,Water; Basified,Rt
    标题:Structure And Evaluation Of Antibacterial And Antitubercular Properties Of New Basic And Heterocyclic 3-Formylrifamycin Sv Derivatives Obtained Via 'Click Chemistry' Approach
    作者:Pyta,Krystian; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2014 卷标:84 页码:651-676]

    100910-72-3 = 88192-19-2
    反应条件:1.1 Reagents: Triphenylphosphine,Hydrochloric Acid Solvents: Diethyl Ether,Ethyl Acetate,Water; 1 H,Rt; 1 H,0 °C; 24 H,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Basified,Rt
    标题:Clickable Artificial Heme-Peroxidases For The Development Of Functional Nanomaterials
    作者:Zambrano,Gerardo; Et Al
    参考文献:Biotechnology And Applied Biochemistry 日期:2020 卷标:67(4) 页码:549-562]

    129392-84-3 = 88192-19-2
    反应条件:1.1 Reagents: Acetyl Chloride Solvents: Methanol; 10 Min,0 °C1.2 Solvents: Methanol; 0 °C; 17 H,23 °C
    标题:Bifunctional Diaminoterephthalate Fluorescent Dye As Probe For Cross-Linking Proteins
    作者:Wallisch,Melanie; Et Al
    参考文献:Chemistry - A European Journal 日期:2017 卷标:23(27) 页码:6535-6543]

    14753-26-5 = 88192-19-2
    反应条件:1.1 Reagents: Sodium Azide Solvents: Water; Overnight,80 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; Neutralized
    标题:Carbohydrate-Naphthalene Diimide Conjugates As Potential Antiparasitic Drugs: Synthesis,Evaluation And Structure-Activity Studies
    作者:Zuffo,M.; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2019 卷标:163 页码:54-66]

    14753-26-5 = 88192-19-2
    反应条件:1.1 Reagents: Sodium Azide Solvents: Water; Rt; 16 H,80 °C1.2 Reagents: Potassium Hydroxide Solvents: Water; Ph 11,< 5 °C
    标题:Azidopropylvinylsulfonamide As A New Bifunctional Click Reagent For Bioorthogonal Conjugations: Application For Dna-Protein Cross-Linking
    作者:Dadova,Jitka; Et Al
    参考文献:Chemistry - A European Journal 日期:2015 卷标:21(45) 页码:16091-16102]

    6276-54-6 = 88192-19-2
    反应条件:1.1 Reagents: Sodium Azide Solvents: Water; 15 H,Rt -> 80 °C1.2 Reagents: Potassium Hydroxide
    标题:Pre-Blocked Molecular Shuttle As An In-Situ Real-Time Theranostics
    作者:Sun,Tao; Et Al
    参考文献:Biomaterials 日期:2019 卷标:204 页码:46-58]

    6276-54-6 = 88192-19-2
    反应条件:1.1 Reagents: Sodium Azide Solvents: Water; 15 H,Rt -> 80 °C1.2 Reagents: Potassium Hydroxide; Basified
    标题:Modification Of Dna-Templated Conductive Polymer Nanowires Via Click Chemistry
    作者:Hannant,Jennifer; Et Al
    参考文献:Chemical Communications (Cambridge 日期:2010 卷标:46(32) 页码:5870-5872]

    118668-55-6 = 88192-19-2
    反应条件:1.1 Reagents: Sodium Azide Solvents: Water
    标题:Chemically Tunable Mucin Chimeras Assembled On Living Cells
    作者:Kramer,Jessica R.; Et Al
    参考文献:Proceedings Of The National Academy Of Sciences Of The United States Of America 日期:2015 卷标:112(41) 页码:12574-12579]

    5003-71-4 = 88192-19-2
    反应条件:1.1 Reagents: Sodium Azide Solvents: Water; 16 H,Rt -> 100 °C; 100 °C -> Rt1.2 Reagents: Potassium Hydroxide Solvents: Diethyl Ether; Cooled; < 10 °C
    标题:Photolabile Linkers: Exploiting Labile Bond Chemistry To Control Mode And Rate Of Hydrogel Degradation And Protein Release
    作者:Le Valley,Paige J.; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2020 卷标:142(10) 页码:4671-4679]

    5003-71-4 = 88192-19-2
    反应条件:1.1 Reagents: Sodium Azide Solvents: Water; Rt -> Reflux; 24 H,Reflux; Cooled1.2 Reagents: Potassium Hydroxide Solvents: Water; Ph 14,< 10 °C
    标题:Topology And Molecular Architecture Of Polyelectrolytes Determine Their Ph-Responsiveness When Assembled On Surfaces
    作者:Trachsel,Lucca; Et Al
    参考文献:Acs Macro Letters 日期:2021 卷标:10(1) 页码:90-97]

    41236-20-8 = 88192-19-2
    反应条件:1.1 Reagents: Sodium Azide Solvents: Water; 24 H,80 °C
    标题:Synthesis Of Novel 1,4,7,10-Tetraazacyclodecane-1,4,7,10-Tetraacetic Acid (Dota) Derivatives For Chemoselective Attachment To Unprotected Polyfunctionalized Compounds
    作者:Knoer,Sebastian; Et Al
    参考文献:Chemistry - A European Journal 日期:2007 卷标:13(21) 页码:6082-6090]

    41236-20-8 = 88192-19-2
    反应条件:1.1 Reagents: Sodium Azide Solvents: Water; 24 H,80 °C; Cooled1.2 Reagents: Potassium Hydroxide Solvents: Diethyl Ether; Ph 14,< 10 °C
    标题:First Poly(2-Oxazoline)-Peptide Conjugate For Targeted Radionuclide Cancer Therapy
    作者:Luxenhofer,Robert; Et Al
    参考文献:Pmse Preprints 日期:2006 卷标:95 页码:283-284]

    41236-20-8 = 88192-19-2
    反应条件:1.1 Reagents: Sodium Azide Solvents: Water; Overnight,Rt -> Reflux1.2 Reagents: Potassium Hydroxide; Basified
    标题:Blood-Brain Barrier-Permeable Fluorone-Labeled Dieckols Acting As Neuronal Er Stress Signaling Inhibitors
    作者:Kwak,Jong Hwan; Et Al
    参考文献:Biomaterials 日期:2015 卷标:61 页码:52-60]

    18370-81-5 = 88192-19-2
    反应条件:1.1 Reagents: Sodium Azide Solvents: Water; 16 H,Reflux1.2 Reagents: Potassium Hydroxide Solvents: Diethyl Ether; < 10 °C
    标题:Cyclodextrin-/photoisomerization-Modulated Assembly And Disassembly Of An Azobenzene-Grafted Polyoxometalate Cluster
    作者:Li,Hongbo; Et Al
    参考文献:Dalton Transactions 日期:2019 卷标:48(16) 页码:5168-5175]

    6266-35-9 = 88192-19-2
    反应条件:1.1 Reagents: Sodium Azide Catalysts: Potassium Iodide Solvents: Water; Rt -> 90 °C; 3 D,90 °C; 90 °C -> Rt; Rt -> 0 °C1.2 Reagents: Sodium Hydroxide; Ph 14,0 °C
    标题:Loops Versus Branch Functionality In Model Click Hydrogels
    作者:Kawamoto,Ken; Et Al
    参考文献:Macromolecules (Washington 日期:2015 卷标:48(24) 页码:8980-8988]

    2403-33-0 = 88192-19-2
    反应条件:1.1 Reagents: Sodium Azide Solvents: Water; 14 H,Rt -> 90 °C
    标题:Entirely Oligosaccharide-Based Supramolecular Amphiphiles Constructed Via Host-Guest Interactions As Efficient Drug Delivery Platforms
    作者:Shi,Yuting; Et Al
    参考文献:Chemical Communications (Cambridge 日期:2017 卷标:53(91) 页码:12302-12305]

    38862-24-7 + 88192-19-2 + 2530-85-0 + 2680-03-7 = 88192-19-2
    反应条件:1.1 Catalysts: Azobisisobutyronitrile Solvents: Tetrahydrofuran; 5 H,Rt
    标题:Layer-By-Layer Deposition Of Functional Click Polymers For Microarray Applications
    作者:Sola,L.; Et Al
    参考文献:Express Polymer Letters 日期:2019 卷标:13(11) 页码:1004-1017
📜3-氨基-1-丙醇置于氯化亚砜,Sodium Azide体系中,用 氯仿,水 作为反应溶剂,化学反应 27.0H,反应生成 3-叠氮基丙胺
参考文献:細胞内送達ベヒクル
标题:細胞内送達ベヒクル
摘要:提供表面带有阳性电荷覆盖的细胞内传递载体,以便在不妨碍细胞增殖的情况下轻松传递所需的成分或化合物.

专利信息


专利号:US-6492136-B1
优先权日:1995-12-07
标题 :Solid phase organic synthesis
发明人：FLITSCH SABINE LAHJA; TURNER NICHOLAS JOHN
权利人:GENZYME LTD
摘要:A method of synthesis of a material corresponding to the general formula:characterized in that it comprises a material corresponding to the following general formula:being cleaved as indicated enzymatically or non-enzymatically using acid catalysis in the presence of a nucleophile, wherein: R1 represents a group providing the site for exo-enzyme or acid hydrolysis; R2 represents an intermediate linked to a solid support; R3 represents a carbohydrate, (oligo-)saccharide, (glyco-)peptide, (glyco-)lipid or an organic molecule which is at least one of heterocyclic and aromatic in structure; X represents O, N(H), N(R''), C(O)O, S, C(O)N(H) or C(O)N(R''), R'' being a non-interfering group; and Support represents a solid support.

专利号:US-2021371389-A1
优先权日:2020-04-24
标题:One-step synthesis of soybean polyols
发明人：SANTRA SANTIMUKUL
权利人:KANSAS SOYBEAN COMMISSION
摘要:A method of producing a triazoline-containing compound, the method comprising reacting an alkene, which comprises at least one a Câ•?C double bond, with an azido compound, which comprises an azide anion having the chemical formula N 3 − , wherein the alkene and the azido compound are constituents of a reaction mixture, so that a C—C single bond forms between the carbon atoms of the at least one Câ•?C double bond and each of carbon atom of the C—C single bond also has a single bond with a different nitrogen atom of the azide anion thereby producing the triazoline-containing compound.

专利号:US-2025082793-A1
优先权日:2021-11-09
标 题 :Macrocyclic compounds and methods of making the same
发明人：CLEATOR EDWARD; MATON WILLIAM MARC; SALTER RHYS
权利人:JANSSEN BIOTECH INC
摘要:The present invention is directed to the preparation of key intermediates and synthesis of compounds (macrocyclic compounds) and pharmaceutically acceptable salts thereof, immunoconjugates, radioimmunoconjugates thereof, pharmaceutical compositions containing said compounds and immunoconjugates, radioimmunoconjugates thereof.

专利号:US-9555008-B2
优先权日:2008-04-02
标题 :Synthesis of hyperbranched amphiphilic polyester and theranostic nanoparticles thereof
发明人：PEREZ J MANUEL; SANTRA SANTIMUKUL
权利人:UNIV CENTRAL FLORIDA RES FOUND INC
摘要:A method of making a hyperbranched amphiphilic polyester compound includes drying under vacuum a mixture of 2-(4-hydroxybutyl)-malonic acid and p-toluene sulphonic acid as catalyst. The vacuum is then released with a dry inert gas after drying. The dried mixture is heated under the inert gas at a temperature sufficient for polymerization. The inert gas is evacuated while continuing to heat the mixture. The formed polymer is then dissolved in dimethylformamide and precipitated out by adding methanol. Modifications of the method yield nanoparticles of polyesters having properties suited for coencapsulating fluorescent dyes together with therapeutic drugs, resulting in theranostic nanoparticles, that is, nanoparticles useful in both therapeutic treatments and diagnostic methods.

专利号:US-11427612-B2
优先权日:2018-08-21
标题:Epimerization-free N to C solid-phase peptide synthesis
发明人：STOCKDILL JENNIFER L; ARBOUR CHRISTINE A
权利人:UNIV WAYNE STATE
摘要:The present disclosure provides a method of solid-phase peptide synthesis from the N terminus to C terminus without detectable epimerization of the C-terminal amino acid. The method includes using derivatized amino acids comprising a diamino-aryl group.

专利号:US-9402911-B2
优先权日:2011-12-08
标题:Multifunctional small molecules
发明人：BAKER JR JAMES R; HUANG BAOHUA M; THOMAS THOMMEY P
权利人:UNIV MICHIGAN REGENTS
摘要:The present invention relates to dendrimer synthesis. Specifically, the present invention relates to dendrimer compositions (e.g., scaffolds) capable of copper-free click conjugation for use in the synthesis of functionalized dendrimers, and methods of use of the same.

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主要参考文献

[参考文献]: Mai K, Et, Al. Cationic Dendronization Of Amylose Via Click Chemistry For Complexation And Transfection Of Plasmid Dna. Int J Biol Macromol. 2015 Aug;79:209-16.

合成参考文献


摘要:Wessjohann, L. A.; Kaluđerović, G. N.; Neves Filho, R. A. W.; Morejon, M. C.; Lemanski, G.; Ziegler, T., Science of Synthesis: Multicomponent Reactions, (2013) 1, 423.
摘要:Wessjohann, L. A.; Kaluđerović, G. N.; Neves Filho, R. A. W.; Morejon, M. C.; Lemanski, G.; Ziegler, T., Science of Synthesis: Multicomponent Reactions, (2013) 1, 425.
摘要:Kacprzak, K. M.; Skiera, I.; Rutkowski, J., Science of Synthesis, (2021) , 234.
参考文献:10.1007/978-1-61779-148-2_6
摘要:Krusemark CJ, Frey BL, Smith LM, Belshaw PJ. Complete chemical modification of amine and acid functional groups of peptides and small proteins. Methods Mol Biol. 2011;753():77–91.
参考文献:10.1186/s12951-021-01227-2
摘要:Kim J, Hwang DW, Jung HS, Kim KW, Pham X, Lee S, Byun JW, Kim W, Kim H, Hahm E, Ham K, Rho W, Lee DS, Jun B. High-quantum yield alloy-typed core/shell CdSeZnS/ZnS quantum dots for bio-applications. Journal of Nanobiotechnology. 2022 Jan 06;20(1):22. doi: 10.1186/s12951-021-01227-2.
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