CAS: 6960-45-8; 7-Nitro-1H-Indole-2-Carboxylic Acid

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CAS号6960-46-9 7-硝基吲哚-2-羧酸乙酯 | CAS号167027-28-3 7-nitro-1H-indo... | CAS号292853-66-8 ethyl 2-[2-(2-n... | CAS号6960-42-5 7-硝基吲哚 | CAS号5192-04-1 7-氨基吲哚

📜Ethyl 2-Methyl-3-[2-(2-Nitrophenyl)Hydrazono]Propanoate置于sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应生成 7-硝基吲哚-2-甲酸
参考文献:Discovery Of Potent Succinate-Ubiquinone Oxidoreductase Inhibitors Via Pharmacophore-Linked Fragment Virtual Screening Approach
标题:Discovery Of Potent Succinate-Ubiquinone Oxidoreductase Inhibitors Via Pharmacophore-Linked Fragment Virtual Screening Approach
摘要:Succinate-Ubiquinone Oxidoreductase (Sqr) Is An Attractive Target For Fungicide Discovery. Herein,We Report The Discovery Of Novel Sqr Inhibitors Using A Pharmacophore-Linked Fragment Virtual Screening Approach,A New Drug Design Method Developed In Our Laboratory. Among Newly Designed Compounds,Compound 9S Was Identified As The Most Potent Inhibitor With A Value Of 34 Nm Against Porcine Sqr,Displaying Approximately 10-Fold Higher Potency Than That Of The Commercial Control Penthiopyrad. Further Inhibitory Kinetics Studies Revealed That Compound 9S Is A Noncompetitive Inhibitor With Respect To The Substrate Cytochrome C And Dcip. Interestingly,Compounds 8A,9H,9J,And 9K Exhibited Good In Vivo Preventive Effects Against Rhizoctonia Solani. The Results Obtained From Molecular Modeling Showed That The Orientation Of The R-2 Group Had A Significant Effect On Binding With The Protein.
DOI:10.1021/acs.Jafc.6B00325

专利信息

专利号:US-7563571-B1
优先权日:2004-07-22
标题 :MYH gene variants and use thereof
发明人：SCHOLL THOMAS; ELIASON KRISTILYN; JUDKINS THADDEUS S
权利人:MYRIAD GENETICS INC
摘要:Variants in MYH gene are disclosed which can result in abnormal synthesis of MYH proteins and alteration of MYH activities. The invention provides methods for detecting the newly discovered genetic variants. Use of MYH genetic variants as biomarkers in diagnosing cancer and detecting a predisposition to cancer are also disclosed herein.

专利号:US-6989384-B2
优先权日:2000-06-14
标题:Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
发明人：HUA YE; LUU HIEP THE; CHAN FORA P; JOHNSON JR THEODORE O; REICH SIEGFRIED HEINZ; SKALITZKY DONALD JAMES; YANG YI; HENDRICKSON THOMAS F; CHU SHAO SONG; EASTMAN BRIAN WALTER
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n nwhere the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-10398732-B2
优先权日:2016-10-13
标题 :Compositions and methods for treating striated muscle injury, treating striated muscle atrophy and/or for promoting striated muscle growth
发明人：WU MIAOZONG; WANG CUIFEN; BLOUGH ERIC
权利人:MARSHALL UNIV RESEARCH CORPORATION
摘要:Compositions and methods for treating striated muscle injury, treating striated muscle atrophy, and/or for promoting striated muscle growth are provided and include administering zinc oxide nanoparticles to a subject in need thereof. The zinc oxide nanoparticles can be adminstered before, during, and/or after exposure to an injurious stimuli, such as radiation. Administration of the zinc oxide nanoparticles reduces activation of autophagy regulators, increases striated muscle anabolism, increases DNA repair signaling, and/or increases striated muscle protein synthesis and growth.

专利号:US-9517244-B2
优先权日:2011-04-22
标 题 :Therapeutic combinations for use in neoplasia
发明人：NARAYAN SATYA; JAISWAL ARUNA S; OSTROV DAVID A; HONG SUKWON
权利人:NARAYAN SATYA; JAISWAL ARUNA S; OSTROV DAVID A; HONG SUKWON; UNIV FLORIDA
摘要:The invention features compositions and methods that are useful for the treatment of neoplasia (e.g., pancreatic cancer, colon cancer, brain cancer) by increasing DNA damage, reducing nucleotide synthesis, and reducing base excision repair (BER).