CAS: 6729-55-1; (2R)-2-Amino-5-(Carboxymethylamino)-5-Oxopentanoic Acid

该化合物是一种由氨酸D-甘酸和甘油组成的二酸二酸二酸基和甘油二酸基组成的二硝酸二酸基组与氨基甘油组之间的一种丙酸联结,形成一种具有peptides特征的结构. -D-甘基甘油因其在各种生物化学过程中的作用而引人注目,特别是在...

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    上下游产品

    5-oxo-1-(toluene-4-sulfonyl)-D-proline 1-(4'-methylbenzenesulfonyl)-5-oxopyrrolidine-2-carboxylic acid B°C-D-Glu-OEt

    合成工艺路线路线简述

      📜5-氧代-1-(甲苯-4-磺酰基)-D-脯氨酸置于n-乙基哌啶,Sodium Hydroxide,氨,Sodium,乙腈体系中,化学反应生成 γ-D-谷氨酰基甘氨酸
      参考文献:Rudinger; Czurbova,Collection Of Czechoslovak Chemical Communications,1954,Vol. 19,P. 386,390
      标题:Rudinger; Czurbova,Collection Of Czechoslovak Chemical Communications,1954,Vol. 19,P. 386,390

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      1: Wu Z, Foster AC, Staubli U, Wu X, Sun C, Tang X, Li YX, Chen G. Effects of 3-aminoglutarate, a "silent" false transmitter for glutamate neurons, on synaptic transmission and epileptiform activity. Neuropharmacology. 2015 Oct;97:95-103. doi: 10.1016/j.neuropharm.2015.05.011. Epub 2015 May 19. doi: 10.3389/fncel.2014.00143. eCollection 2014.
      3: Auger C, Ogden D. AMPA receptor activation controls type I metabotropic glutamate receptor signalling via a tyrosine kinase at parallel fibre-Purkinje cell synapses. J Physiol. 2010 Aug 15;588(Pt 16):3063-74. doi: 10.1113/jphysiol.2010.191080. Epub 2010 Jul 5.
      4: Omrani A, Melone M, Bellesi M, Safiulina V, Aida T, Tanaka K, Cherubini E, Conti F. Up-regulation of GLT-1 severely impairs LTD at mossy fibre--CA3 synapses. J Physiol. 2009 Oct 1;587(Pt 19):4575-88. doi: 10.1113/jphysiol.2009.177881. Epub 2009 Aug 3.

      合成参考文献


      参考文献:10.1523/jneurosci.5342-05.2006
      摘要:Takayasu Y, Iino M, Shimamoto K, Tanaka K, Ozawa S. Glial Glutamate Transporters Maintain One-to-One Relationship at the Climbing Fiber-Purkinje Cell Synapse by Preventing Glutamate Spillover. Journal of Neuroscience. 2006 Jun 14;26(24):6563–72. doi: 10.1523/jneurosci.5342-05.2006.
      参考文献:10.1152/jn.00586.2004
      摘要:Aksenov DP, Serdyukova NA, Bloedel JR, Bracha V. Glutamate neurotransmission in the cerebellar interposed nuclei: involvement in classically conditioned eyeblinks and neuronal activity. J Neurophysiol. 2005 Jan;93(1):44–52. doi: 10.1152/jn.00586.2004.
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