CAS: 6574-98-7; 2,4-Dichlorobenzonitrile

上下游产品

benzenesulfonamide 2,4 dichlorobenzoic acid 2,4-dichlorobenzamide 2,4-Dichloroaniline 2,4-dichloro-N-phenylbenzimidamide 1-(2,4-dichlorophenyl)ethan-1-one 2,4 dichlorobenzoic acid 2,4-dichloro-benzenemethanamine

2,4-二氯苯甲酸置于aluminum Oxide,氨基磺酸,尿素体系中,化学反应 0.1H,以93%的收率获得产物2,4-二氯苯腈
参考文献:微波辐照下无溶剂羧酸高效一锅法合成腈
标题:微波辐照下无溶剂羧酸高效一锅法合成腈
摘要:摘要 在干燥介质条件下,在微波辐射下,由烷基和芳基羧酸制备腈.在微波炉中加热吸附在氧化铝载体上的羧酸,尿素和氨基磺酸,可得到 20-93% 的腈.
DOI:10.1080/00397919608004778

专利信息

专利号:US-12043612-B2
优先权日:2020-05-09
标 题 :Methods of manufacturing a bifunctional compound, ultrapure forms of the bifunctional compound, and dosage forms comprising the same
发明人：ALLAN LAURA E N; CHEN CHUNGPIN HERMAN; DONG HANQING; GROSSO JOHN A; HASKELL III ROYAL J; LLOYD RHYS; REECE HAYLEY
权利人:ARVINAS OPERATIONS INC
摘要:The present disclosure relates to ultra-pure forms, polymorphs, amorphous forms, and formulations of N-[(1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-({4-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]piperazin-1-yl}methyl)piperidin-1-yl]pyridazine-3-carboxamide, referred to herein as Compound A:The present disclosure also relates methods of manufacturing and purifying the same, as well as intermediates useful in the synthesis of Compound A. The ultra-pure forms, polymorphs, amorphous forms, and formulations of Compound A can be used as therapeutic agents for the treatment of various diseases and conditions such as cancer.

专利号:US-4235807-A
优先权日:1979-07-02
标 题:Synthesis of 2,6-disubstituted benzonitriles
发明人：FUHLHAGE DONALD W
权利人:THOMPSON HAYWARD CHEMICAL
摘要:A one step method of converting 2,6-disubstituted benzaldehydes to 2,6-disubstituted benzonitriles which comprises heating benzaldehyde in the presence of a hydroxylamine and a dehydrating agent for about 1 to 40 hours at a temperature of 110°-250° and then separating out the resultant 2,6-disubstituted benzonitrile.

专利号:US-4536599-A
优先权日:1978-08-22
标题:Synthesis of amine derivatives
发明人：MASUKO FUJIO; KATSURA TADASHI
权利人:SUMITOMO CHEMICAL CO
摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.

专利号:US-6960601-B2
优先权日:2001-09-24
标题 :Preparation and use of imidazole derivatives for treatment of obesity
发明人：SMITH ROGER A; O'CONNOR STEPHEN J; WIRTZ STEPHAN-NICHOLAS; WONG WAI C; CHOI SOONGYU; KLUENDER HAROLD C E; SU NING; WANG GAN; ACHEBE FURAHI; YING SHIHONG
权利人:BAYER PHARMACEUTICALS CORP
摘要:This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

专利号:CN-108752217-A
优先权日:2018-07-18
标题:A new method for the synthesis of dolutegravir key intermediate 2,4-difluorobenzylamine

专利号:EP-0040896-B1
优先权日:1978-08-22
标题:Synthesis of amides