CAS: 654-01-3; 2-(2,6-Difluorophenyl)Acetonitrile

上下游产品

CAS号19064-18-7 2,6-二氟苄醇 | CAS号437-81-0 2,6-二氟苯甲醛 | CAS号7677-24-9 三甲基氰硅烷 | CAS号85118-00-9 2,6-二氟溴苄 | CAS号443-84-5 2,6-二氟甲苯 | CAS号443-86-7 3-氟-2-甲基苯胺 | CAS号603-83-8 2-甲基-3-硝基苯胺 | CAS号697-73-4 2,6-二氟氯苄 | CAS号143-33-9 氰化钠 | CAS号2647-31-6 Acrylonitrile,2... | CAS号1525-46-8 Benzeneacetonit... | CAS号359828-68-5 2-(2,6-Difluoro... | CAS号17291-90-6 2-(2,6-Difluoro...

📜3-氟-2-甲基苯胺置于氯体系中,化学反应生成 2,6-二氟苯乙腈
参考文献:Jerumanis,S.; Bruylants,A.,Bulletin Des Societes Chimiques Belges,1960,Vol. 69,P. 312-322
标题:Jerumanis,S.; Bruylants,A.,Bulletin Des Societes Chimiques Belges,1960,Vol. 69,P. 312-322

专利信息

专利号:US-2008319204-A1
优先权日:2007-06-25
标题 :Process for the synthesis of progesterone receptor modulators
发明人：WU YANZHONG; SUTHERLAND KAREN; CONSIDINE JOHN LEO; WILK BOGDAN KAZIMIERZ; GIGUERE PIERRE; MACEWAN MICHAEL; SHARMA ARCHANA; GONTCHAROV ALEXANDER
权利人:WYETH CORP
摘要:Processes for preparing substituted oxindole-2-ones, and specifically the following, are described, wherein R 1 -R 4 , R 6 , and n are defined herein. The processes include reacting a first alkali metal hydroxide, a tetraalkyl ammonium salt, a benzonitrile, and R 6 X or XCH 2 (CH 2 ) n X′, wherein R 6 is C 1 to C 6 alkyl, substituted C 1 to C 6 alkyl, C 3 to C 8 cycloalkyl, substituted C 3 to C 8 cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, or substituted heterocyclic, X and X′ are, independently, leaving groups, and n is 1 to 5; (ii) reacting the product of step (i) with a second alkali metal hydroxide at a temperature of at least about 60° C.; (iii) reacting the product of step (ii) with an alkali alkoxide at a temperature of at least about 140° C. to form an oxindol-2-one; (iv) brominating the oxindol-2-one; and (v) coupling the brominated oxindol-2-one with a coupling reagent.

专利号:CN-118221563-A
优先权日:2024-01-23
标题:Synthesis method of 2-aryl indole