CAS: 6282-88-8; 3-(4-Chlorophenyl)Propan-1-Ol

上下游产品

CAS号2019-34-3 3-(4-氯苯基)丙酸 | CAS号637-87-6 对氯碘苯 | CAS号107-18-6 烯丙醇 | CAS号1615-02-7 4-氯肉桂酸 | CAS号24393-52-0 对氯肉桂酸乙酯 | CAS号7116-36-1 4-氯苯丙酸乙酯 | CAS号1075-77-0 p-Chlor°Cinnama... | CAS号104-88-1 对氯苯甲醛 | CAS号104-83-6 4-氯氯苄 | CAS号20754-21-6 methyl 3-(4-chl... | CAS号225233-78-3 2-Amino-4-(4-ch... | CAS号75677-02-0 3-(4-氯-苯基)-丙醛 | CAS号64473-34-3 1-氯-4-(3-氯丙基)苯

对氯肉桂酸置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 作为反应溶剂,化学反应 4.0H,以54.7%的收率获得产物3-(4'-氯苯基)丙醇
参考文献:2,6-二甲基吗啉新的萘苯醚酮类似物的合成及杀真菌活性的研究
标题:2,6-二甲基吗啉新的萘苯醚酮类似物的合成及杀真菌活性的研究
摘要:摘要以stellera Chamaejasme L.的天然产物1,5-二苯基-2-戊烯-1-酮(i)为前导化合物,设计合成了一系列新型的萘苯醌类似物,其中2,6-二甲基吗啉部分为引入以取代1-苯基.通过红外,1 H NMR和hrms(esi)或元素分析,某些代表性化合物的13 C NMR确认了它们的结构.通过noesy技术和化学方法分离并鉴定了目标化合物的两种异构体.已经评估了所有合成的化合物的抗植物病原性真菌活性.结果表明,某些化合物在50 Mg / L的浓度下对被测真菌表现出中等至非常好的抗真菌活性.其中,化合物7D具有4-溴取代的苯基和顺式-2,6-二甲基吗啉部分,对valsa Mali表现出最佳活性,Ec 50为23.87μmol/ L,优于铅化合物i.此外,初步的结构-活性关系分析表明,在目标化合物的两个异构体之间,该异构体对顺式-2,6-二甲基吗啉的抗真菌活性优于反式异构体.
DOI:10.1016/j.Cclet.2016.01.045

专利信息

专利号:WO-2021023634-A1
优先权日:2019-08-05
标 题 :PROCESS FOR THE SYNTHESIS OF PITOLISANT HCl
发明人：COLOMBANO GIAMPIERO; BARBERO MAURO; BOGOGNA LUIGI; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA
摘要:Disclosed is a process for the synthesis of pitolisant HCl of formula (I), from piperidine and 1-bromo-3-chloropropane. The process according to the invention is economically efficient and easily industrially scalable.

专利号:WO-2017082924-A1
优先权日:2015-11-13
标题 :Peptide and peptide mimetic binding antagonists of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE TERRENCE R JR; HYMEL DAVID
权利人:THE US SECRETARY DEPT OF HEALTH & HUMAN SERVICES
摘要:The description provides novel compounds that may serve as anticancer therapeutics. The compounds of the description bind to polo-like kinases through the polo-box domain. The peptide derivatives of the description have achieved improved efficacy in biochemical assays against Plk1. The description also provides methods of use, methods of preparation, compositions, and kits thereof. Further, the description provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.

专利号:EP-0414686-B1
优先权日:1987-11-26
标题 :Derivatives of trifluoromethyl-1-tetralines, preparation and application thereof for the synthesis of compounds having therapeutic properties
摘要:Derivatives of trifluoromethyl-1-tetralines having the general formula (I), wherein X is a hydrogen atom, a halogen, a hydroxy group, an alkoxy group from C1 to C8 or an optionally substituted aromatic ring; R1 is a hydrogen atom or an halogen, a hydroxy group, a C1-C8 alkoxy group optionally halogenated, occupying one of the positions (5, 6 or 7), or a methylene-dioxy group occupying the positions 5 and 6 or 6 and 7, and R2 is a hydrogen or an halogen atom, a hydroxy group, a linear or branched C1-C8 alkyl group occupying one of the other positions 5, 6 or 7.

专利号:WO-8904819-A1
优先权日:1987-11-26
标 题:Derivatives of trifluoromethyl-1-tetralines, preparation and application thereof for the synthesis of compounds having therapeutic properties

专利号:IT-201900013941-A1
优先权日:2019-08-05
标 题 :PROCESS FOR THE SYNTHESIS OF PITOLISANT HCl

专利号:CN-110804026-B
优先权日:2019-11-18
标题:Synthesis method of 1- (3- (3- (4-chlorphenyl) propoxy) propyl) piperidine hydrochloride