CAS: 5976-61-4; 4-Hydroxy-17β-Estradiol

该化合物是一种自然产生的雌激素,一种按酚化合物分类的异丁醇代谢物,其特征是:在斯大林结构的第四碳位置存在一个氢氧基组,这有利于其生物活动;该化合物显示出雌激素活动,影响各种生理过程,包括生殖功能和骨代谢;其分子配方为C18H24O3,其分子重量相对较低.4-Hydroxyestradicol在有机溶剂中可溶性,在水中溶性有限,影响其生物利用率和在生物系统中的分布;该化合物对药理学和毒理学有兴趣,因为它在荷尔蒙代谢作用和对荷尔蒙相关疾病的潜在影响;此外,它可能参与形成反应性代谢物,可能助长氧化性压力.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

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上下游产品

CAS号3131-23-5 4-羟雌甾酮 | CAS号50-28-2 雌二醇 | CAS号7233-63-8 3,4-bis(acetylo... | CAS号734-32-7 甲基双酮 | CAS号81319-72-4 4,5-Epoxy-5β-es... | CAS号210096-72-3 4,5-Epoxy-5α-es... | CAS号210096-74-5 4,5-Epoxy-5β-es... | CAS号6301-88-8 Estra-1,3,5(10)... | CAS号26788-23-8 1,3,5(10)-雌二醇-3... | CAS号5976-66-9 3-O-甲基 4-羟基雌二醇 | CAS号26890-04-0 4-hydroxyestrad...

合成工艺路线路线简述

    📜4-Nitroestratriene-3,17Beta-Diol置于盐酸,Sodium Hydroxide,Sodium Periodate,Sodium Hydrogensulfite,溶剂黄146体系中,化学反应生成 4-羟雌二醇
    参考文献:Convenient Large Scale Preparation Of Catechol Estrogens
    标题:Convenient Large Scale Preparation Of Catechol Estrogens
    摘要:2-Hydroxyestrone,2-Hydroxyestradiol-17Beta,2-Hydroxy-17Alpha-Ethynylestradiol,2-Hydroxyestriol,4-Hydroxyestrone,4-Hydroxyestradiol-17Beta,4-Hydroxy-17Alpha-Ethynylestradiol And 4-Hydroxyestriol Are Prepared On A Preparative Scale From The Corresponding Aminophenols Using A New Inverse Oxidation Procedure. By The Synthesis Described Both The 2-And 4-Hydroxylated Estrogens Are Available In High Yields.
    DOI:10.1016/0039-128X(76)90010-6

    海关参考信息

    专利信息


    专利号:US-5952183-A
    优先权日:1996-04-19
    标 题 :Synthesis of estrogen-purine base and estrogen-mercapturate adducts and development of fluorescent probes and monoclonal antibodies to assay those adducts
    发明人：CAVALIERI ERCOLE L; CASALE GEORGE P; ROGAN ELEANOR G; STACK DOUGLAS E
    摘要:Estrogen-nucleoside, estrogen-guanine and estrogen-mercapturate adducts are potential biomarkers for determining susceptibility of animals to a number of estrogen related cancers. These adducts may be used as biomarkers for determining risk of estrogen-induced cancers. A linker chemistry has been devised to couple these adducts to protein for production of immunogens, required for production of specific monoclonal antibodies.

    专利号:US-5840889-A
    优先权日:1996-04-19
    标 题 :Synthesis of estrogen-purine base and estrogen-mercapturate adducts and development of fluorescent probes and monoclonal antibodies to assay those adducts

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    主要参考文献


    1: Tang Z, Liu ZH, Wang H, Dang Z, Yin H, Zhou Y, Liu Y. Trace determination of eleven natural estrogens and insights from their occurrence in a municipal wastewater treatment plant and river water. Water Res. 2020 Sep 1;182:115976. doi: 10.1016/j.watres.2020.115976. Epub 2020 May 27.
    256:117910. doi: 10.1016/j.lfs.2020.117910. Epub 2020 Jun 3. 11(8):4992-5007.
    4: Baek HS, Kwon YJ, Ye DJ, Cho E, Kwon TU, Chun YJ. CYP1B1 prevents proteasome- mediated XIAP degradation by inducing PKCε activation and phosphorylation of XIAP. Biochim Biophys Acta Mol Cell Res. 2019 Dec;1866(12):118553. doi: 10.1016/j.bbamcr.2019.118553. Epub 2019 Sep 4. 29(9):686-692. doi: 10.1080/15376516.2019.1650146. Epub 2019 Aug 30.

    合成参考文献


    参考文献:10.1007/s00467-011-1963-1
    摘要:Kummer S, von Gersdorff G, Kemper MJ, Oh J. The influence of gender and sexual hormones on incidence and outcome of chronic kidney disease. Pediatr Nephrol. 2012 Aug;27(8):1213–9. doi: 10.1007/s00467-011-1963-1.
    摘要:Omrani MD, Bazargani S, Bagheri M, Yazdan-Nejad H. Association of catechol-o-methyl transferase gene polymorphism with prostate cancer and benign prostatic hyperplasia. J Res Med Sci. 2009 Jul;14(4):217–22.
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