CAS: 493-80-1; Histapyrrodine

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CAS号123-75-1 四氢吡咯 | CAS号36716-44-6 N-[2-(pyrrolidi... | CAS号100-44-7 氯化苄 | CAS号7250-67-1 N-(2-氯乙基)吡咯烷盐酸盐

📜苯甲基苯胺,2-(Pyrrolidin-1-yl)Ethyl Trifluoromethanesulfonate置于sodium Hydride体系中,用 甲苯,Mineral Oil 作为反应溶剂,以21%的收率获得产物希司吡定
参考文献:Flavin Monooxygenase Metabolism: Why Medicinal Chemists Should Matter
标题:Flavin Monooxygenase Metabolism: Why Medicinal Chemists Should Matter
摘要:Fmo Enzymes (Fmos) Play A Key Role In The Processes Of Detoxification And/or Bioactivation Of Specific Pharmaceuticals And Xenobiotics Bearing Nucleophilic Centers. The N-Oxide And S-Oxide Metabolites Produced By Fmos Are Often Active Metabolites. The Fmos Are More Active Than Cytochromes In The Brain And Work In Tandem With Cyp3A4 In The Liver. Fmos Might Reduce The Risk Of Phospholipidosis Of Cad-Like Drugs,Although Some Fmos Metabolites Seem To Be Neurotoxic And Hepatotoxic. However,In Silico Methods For Fmo Metabolism Prediction Are Not Yet Available. This Paper Reports,For The First Time,A Substrate-Specificity And Catalytic-Activity Model For Fmo3,The Most Relevant Isoform Of The Fmos In Humans. The Application Of This Model To A Series Of Compounds With Unknown Fmo Metabolism Is Also Reported. The Model Has Also Been Very Useful To Design Compounds With Optimal Clearance And In Finding Erroneous Literature Data,Particularly Cases In Which Substances Have Been Reported To Be Fmo3 Substrates When,In Reality,The Experimentally Validated In Silico Model Correctly Predicts That They Are Not.
DOI:10.1021/jm5007098

专利信息

专利号:CN-101302181-A
优先权日:2007-05-09
标 题 :Synthesis and application of four-chelate diamine pyrrole ligand compound