📜2,3,4,6-Tetra-O-Acetyl-D-Glucopyranosyl Bromide置于吡啶,甲醇,三氟化硼乙醚,四丁基溴化铵,Sodium Methylate,溶剂黄146,Sodium Hydroxide,Zinc(II) Chloride体系中,用 二氯甲烷 作为反应溶剂,化学反应 55.0H,反应生成 冬绿苷 参考文献:Synthesis And Anti-Nociceptive And Anti-Inflammatory Effects Of Gaultherin And Its Analogs 标题:Synthesis And Anti-Nociceptive And Anti-Inflammatory Effects Of Gaultherin And Its Analogs 摘要:The Synthesis Of Gaultherin (1) And Its Analogs Was Carried Out To Provide 11 Glycosides Under Phase-Transfer Catalytic Conditions. The Activities Of All Synthesized Compounds Were Evaluated By Nitric Oxide Production Inhibitory Assay In Vitro. Methyl 2-O-(4-O-Beta-D-Galactopyranosyl)-Beta-D-Glucopyranosylbenzoate (5F) Showed Significantly Antinociceptive And Anti-Inflammatory Effects By The Evaluation In Vivo. Structure-Activity Relationships Within These Compounds Were Discussed. DOI:10.1080/10286020.2011.596830
参考文献:10.1124/mol.119.115964 摘要:Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. 2019 Nov;96(5):629–40. doi: 10.1124/mol.119.115964. 参考文献:10.1105/tpc.113.114231 摘要:Tikunov YM, Molthoff J, de Vos RC, Beekwilder J, van Houwelingen A, van der Hooft JJ, Nijenhuis-de Vries M, Labrie CW, Verkerke W, van de Geest H, Viquez Zamora M, Presa S, Rambla JL, Granell A, Hall RD, Bovy AG. Non-smoky glycosyltransferase1 prevents the release of smoky aroma from tomato fruit. Plant Cell. 2013 Aug;25(8):3067–78.