CAS: 4277-34-3; Cyclooct-4-Enol

相似化合物

85081-69-2 31501-39-0 39637-78-0

📜(Z)-Cyclooct-4-En-1-Yl (1R,4S)-4,7,7-Trimethyl-3-Oxo-2-Oxabicyclo[2.2.1]Heptane-1-Carboxylate置于sodium Hydroxide体系中,用 四氢呋喃,水 作为反应溶剂,以52 %的收率获得产物(E)-环辛-4-烯醇/赤道-Tco/e
参考文献: Method For Providing A Labeled Single Isomeric Chemical Entity Targeting Vector Based On The Use Of A Symmetrical Diene[fr] Procédé Permettant D'Obtenir Un Vecteur Ciblant Une Entité Chimique Monoisomère Marqué à Base De L'Utilisation D'Un Diène Symétrique
标题: Method For Providing A Labeled Single Isomeric Chemical Entity Targeting Vector Based On The Use Of A Symmetrical Diene[fr] Procédé Permettant D'Obtenir Un Vecteur Ciblant Une Entité Chimique Monoisomère Marqué à Base De L'Utilisation D'Un Diène Symétrique
摘要:The Present Disclosure Regards A Method For Providing Labeled Single Isomeric Chemical Entity Targeting Vectors Suitable For Providing Targeting Vectors. The Method Applies Specific Combinations Between A Diene And A Dienophile With Complementary Inverse Electron Demand Diels-Alder Cycloaddition Reactivity,Which Upon Ligation,Followed By Oxidation,Will Form Compounds Of A Single Isomeric Form. The Labeled Single Isomeric Chemical Entity Targeting Vectors Are For Use In Therapy,Radiotherapy,Theranostics,Diagnostics,And Imaging. The Method Applies Click Chemistry Wherein One Chemical Entity Which Is Conjugated To A Label Is Clicked Together With A Second Chemical Entity With Complementary Inverse Electron Demand Diels-Alder Cycloaddition Reactivity Which Is Conjugated To A Targeting Vector Followed By A Rapid Oxidation,To Form A Single Isomeric Compound.

专利信息

专利号:US-7105617-B2
优先权日:2003-02-06
标题:Metal 8-hydroxyquinoline-functionalized polymers and related materials and methods of making and using the same
发明人：WECK MARCUS; MEYERS AMY
权利人:GEORGIA TECH RES INST
摘要:This invention relates to the synthesis of Mq n -containing monomeric compounds, comprising a polymerizable moiety, an Mq n -moiety, and an optional chemical spacer therebetween, wherein q, in each instance, comprises an 8-hydroxyquinoline residue, M is a metal such as Mg, Zn, Al, Ga, or In, and n is 2 or 3 as the valence of the metal requires. For example, the polymerization of Znq 2 - or Alq 3 -containing monomers, in the presence or absence of a co-monomer, provided a Znq 2 - or Alq 3 -containing polymer, which retained the optical properties of Znq 2 or Alq 3 in solution, respectively. The Mq n -containing polymers may be used in, among other things, the fabrication of light-emitting diodes (LEDs).

专利号:US-9932423-B2
优先权日:2015-09-24
标题:Hydrogenation of annulated cyclopentadienyl metal complexes and metallocene catalysts comprising such
发明人：MCCULLOUGH LAUGHLIN G
权利人:EXXONMOBIL CHEMICAL PATENTS INC
摘要:Disclosed are methods for making partially hydrogenated annulated cyclopentadienyl complexes which can provide efficient synthesis of metallocene catalysts desired for olefin polymerization.

专利号:US-7989544-B2
优先权日:2003-09-05
标题 :Amphiphilic polymer capsules and related methods of interfacial assembly
发明人：EMRICK TODD S; BREITENKAMP KURT
权利人:UNIV MASSACHUSETTS
摘要:Polymer capsules from amphiphilic graft copolymers comprising reactive, hydrophobic polyolefin backbones, and hydrophilic poly(ethylene glycol) (PEG) grafts are produced by self-assembly of the polymers at the oil-water interface, and crosslinking the assembly with bis-cyclooctene PEG derivatives in conjunction with ring-open metathesis polymerization catalysts. The use of the graft copolymer architecture in capsule synthesis provides significant opportunities to tune both the surface properties, in terms of recognition, and the membrane properties, in terms of mechanical strength, encapsulation, and release.

专利号:US-9315537-B2
优先权日:2011-09-02
标题:Multiple orthogonal labelling of oligonucleotides
发明人：BECKER JULIANE; Jäschke Andres; SAMANTA AYAN; WIESSLER MANFRED
权利人:BECKER JULIANE; Jäschke Andres; SAMANTA AYAN; WIESSLER MANFRED; DEUTSCHES KREBSFORSCH; UNIV RUPRECHT KARLS HEIDELBERG
摘要:In summary, the present invention concerns a method for multiple orthogonal labelling of oligonucleotides, preferably RNA or DNA, by simultaneously performing the inverse Diels-Alder reaction (DAinv) and the copper-catalyzed click reaction (CuAAC), wherein the method is employed in a single step by just adding the different reaction components together and incubating the aqueous reaction mixture preferably for one hour at room temperature. In detail, the reaction components are one or more N 3 -modified labels, a copper compound, a stabilizing ligand, a reducing agent and one or more electron-deficient label-modified dienes that are added together with an at least double-modified oligonucleotide having one more nucleotides containing one or more N3-reactive groups and one or more electron-rich dienophiles, wherein a terminal alkyne moiety is preferably used as N3-reactive group(s) and a frans-cyclooctene moiety or norbornene is preferably used as electron-rich dienophile(s), more preferably frans-cyclooctene. Therefore, the present invention provides a one-pot method for post-synthetic multiple orthogonal labeling of oligonucleotides, which allows the site-specific introduction of more than one label, preferably of at least two labels into oligonucleotides after solid-phase synthesis, wherein the DAinv takes place on the dienophile modification only and the CuAAC selectively takes place on the N3-reactive group modification.

专利号:US-10882932-B2
优先权日:2016-10-05
标题:Sterically hindered metallocenes, synthesis and use
发明人：CROWTHER DONNA J; MCCULLOUGH LAUGHLIN G; LOVELL JACQUELINE A
权利人:EXXONMOBIL CHEMICAL PATENTS INC
摘要:In at least one embodiment, a catalyst compound is represented by Formula (I): n n n n n n n n n n n n where M is a group 4 metal. Each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , and R 14 is independently hydrogen, or a linear or branched C 1 -C 50 substituted or unsubstituted hydrocarbyl, halocarbyl or silylcarbyl. At least one of R 1 and R 3 is not hydrogen. Each X is independently a halide or C 1 -C 50 substituted or unsubstituted hydrocarbyl, hydride, amide, alkoxide, sulfide, phosphide, halide, diene, amine, phosphine, ether, or a combination thereof, or two Xs are joined together to form a metallocycle ring, or two Xs are joined to form a chelating ligand, a diene ligand, or an alkylidene.

专利号:US-11525041-B2
优先权日:2018-06-15
标 题:Process for producing polymers
发明人：REIMERS JAY L; HONG YIFENG; DIAS ANTHONY J; HAGADORN JOHN R
权利人:EXXONMOBIL CHEMICAL PATENTS INC; EXXONMOBIL CHEMICALS PATENTS INC
摘要:A process for the synthesis of a granular polymer, the process comprising (a) providing an active polymerization mixture that includes polymer, monomer, catalyst and optional solvent; (b) introducing a hydroxy-containing diaryl acetyl compound to the active polymerization mixture to thereby provide an inactive polymer mixture; (c) separating the polymer solution into a first stream and a second stream, where the first stream includes the polymer and the hydroxy-containing diaryl acetyl compound, and the second stream includes the monomer and the optional solvent; and (d) fabricating granules from the first stream.