CAS: 33125-05-2; Boc-D-Phg-Oh

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3601-66-9 102410-65-1 111524-95-9

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CAS号24424-99-5 二碳酸二叔丁酯 | CAS号875-74-1 D-(-)-α-苯基甘氨酸 | CAS号67341-01-9 N-(叔丁氧羰基)-DL-2-苯甘氨醇 | CAS号762-75-4 甲酸叔丁酯 | CAS号4248-19-5 氨基甲酸叔丁酯 | CAS号100-52-7 苯甲醛 | CAS号150884-50-7 (苯基亚甲基)氨基甲酸叔丁酯 | CAS号155396-71-7 tert-butyl N-[b... | CAS号19883-41-1 D-苯甘氨酸甲酯盐酸盐 | CAS号67341-01-9 N-(叔丁氧羰基)-DL-2-苯甘氨醇 | CAS号875-74-1 D-(-)-α-苯基甘氨酸 | CAS号3577-01-3 头孢来星 | CAS号129157-10-4 (R)-(+)-N-异丙基-1... | CAS号137284-11-8 2-Methyl-2-prop... | CAS号141190-94-5 2-((叔丁氧基羰基)氨基)-...

苯甲酰硝基甲烷置于ammonium Cerium (Iv) Nitrate,(R)-N-(Phenylcarbamoyl)-Tert-Butanesulfinamide,三氯硅烷,水,四氯化钛,溶剂黄146,三乙胺,Sodium Nitrite体系中,用 二甲基亚砜,甲苯,乙腈 作为反应溶剂,化学反应 72.5H,反应生成 Boc-D-苯甘氨酸
参考文献:以简单的n-亚磺酰基尿素为双功能催化剂的β-氨基硝基烯烃的高度对映选择性还原
标题:以简单的n-亚磺酰基尿素为双功能催化剂的β-氨基硝基烯烃的高度对映选择性还原
摘要:简单但有效:发现结构简单的n-亚磺酰基尿素是一种高效的双功能催化剂,它允许通过三氯硅烷对映体选择性还原β-氨基硝基烯烃来开发构建手性β-氨基硝基链烷烃的新途径.对于广泛的β-芳基氨基硝基烯烃底物,均获得了高收率和出色的对映选择性(参见方案).
DOI:10.1002/chem.201201192

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-4520193-A
优先权日:1980-11-20
标题 :Cephalosporin derivatives
发明人：BERGER CHRISTIAN; FARGE DANIEL; MOUTONNIER CLAUDE; WOLFF GERARD
权利人:RHONE POULENC IND
摘要:The invention provides new cephalosporin derivatives of the general formula, ##STR1## which are in the form of a bicyclooct-2-ene or bicyclooct-3-ene, in which formula R 1 is a radical of the general formula ##STR2## [in which R 5 is hydrogen, alkyl, vinyl, cyanomethyl, protected carboxyalkyl or a protective radical and R 6 is a protective radical] or an amino-protecting radical, R 2 is an acid-protecting radical and R° represents various organic radicals, or alternatively R 1 is an amino-protecting radical or various acyl radicals, R 2 is a protective radical and R° represents various organic radicals, and R 3 and R 4 are alkyl radicals optionally substituted by alkoxy or dialkylamino, or phenyl radicals, or --NR 3 R 4 forms a heterocyclic ring. These products are intermediates for the synthesis of cephalosporins having antibacterial activity.

专利号:US-3994883-A
优先权日:1972-12-27
标 题 :Penicillin and cephalosporin intermediates
发明人：BORREVANG POUL; GUDDAL ERLING; PETERSEN HENNING BORGE; FAARUP PETER; NIELSEN JORGEN ILUM
权利人:NOVO INDUSTRI AS
摘要:Novel penicillin and cephalosporin intermediates for the synthesis of 6-APA or 7-aminocephem compounds involving formation of a 6 or 7 phosphite amido compound and the conversion of such compound to a desired 6-APA or 7-aminocephem compound.

专利号:US-2004106598-A1
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting Beta-amyloid peptide release and/or its synthesis by use of such compounds