专利号:EP-4421075-A1 优先权日:2023-02-27 标 题 :Process for the preparation of venetoclax and intermediates used therein 发明人:BERGANT SIMONCIC ANA 权利人:KRKA D D NOVO MESTO 摘要:The invention relates to a process for the synthesis of Venetoclax. The invention further relates to intermediates that are useful in the synthesis of Venetoclax.
专利号:US-8674143-B2 优先权日:2008-10-15 标 题 :Synthesis of green ketone intermediate 发明人:BONRATH WERNER; LETINOIS ULLA; SCHUETZ JAN 权利人:BONRATH WERNER; LETINOIS ULLA; SCHUETZ JAN; DSM IP ASSETS BV 摘要:A process for the preparation of 1-ethynyl-3,3-dimethylcyclohexan-1-ol from dimedone by a reaction sequence of reduction and ethynylation and its further transformation into green ketone.
专利号:US-5698600-A 优先权日:1995-10-24 标题:Process for the production of bisphenols with the use of new cocatalysts 发明人:WULFF CLAUS; FENNHOFF GERHARD; EITEL ALFRED 权利人:BAYER AG 摘要:The invention relates to the synthesis of bisphenols from monophenols and carbonyl compounds such as aldehydes and ketones with concentrated mineral acids such as hydrochloric acid and/or hydrogen chloride gas as acid catalysts and a mercaptan as cocatalyst, which is fixed by an ion-pair bond to a matrix insoluble in the reaction medium.
专利号:EP-2128118-A1 优先权日:2008-05-28 标 题:Synthesis of mono-ketones from 1,3-diketones 发明人:BONRATH WERNER; LETINOIS ULLA 权利人:DSM IP ASSETS BV 摘要:The present invention is directed to a process for the manufacture of a mono-ketone comprising the step of hydrogenating a 1,3-diketone with hydrogen in the presence of a bifunctional catalyst having an acid functionality and a hydrogenation functionality.
专利号:US-2022073513-A1 优先权日:2018-12-29 标题:1h-pyrrolo[2,3-b]pyridine derivatives and related compounds as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases 发明人:CHEN YI 权利人:NEWAVE PHARMACEUTICAL INC 摘要:The present invention relates to compounds of Formula (II) and more preferably to 1H-pyrrolo[2,3-b]pyridine derivatives of formula (III) and related compounds. The variables are defined in the claims. The compounds are BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis of exemplary compounds as well as pharmacological data thereof (pages 61 to 72; examples 1 to 4; tables). An exemplary compound is e.g. 4-(4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl]piperazin-1-yl)-2-[methyl(1H-pyrrolo[2,3-b]pyridin-5-yl)phosphoroso]-N-[3-nitro-4-[(oxan-4-yl methyl)amino]benzenesulfonyl]benzamide (example 1).
专利号:US-4054606-A 优先权日:1974-05-31 标题:Process for the preparation of ketone derivatives 发明人:NAF FERDINAND 权利人:FIRMENICH & CIE 摘要:Process for the preparation of α-substituted cyclic ketones which comprises reacting a magnesium enolate with an aldehyde. The products obtained in accordance with the process of the invention are useful intermediates for the preparation of perfume and flavor ingredients, as well as for the synthesis of certain carotenoids.
摘要:Santana, V. C. S.; Munaretto, L. S.; de Lucca, E. C., Jr., Science of Synthesis Knowledge Updates, (2022) 1, 206. 摘要:Santana, V. C. S.; Munaretto, L. S.; de Lucca, E. C., Jr., Science of Synthesis Knowledge Updates, (2022) 1, 173. 摘要:Santana, V. C. S.; Munaretto, L. S.; de Lucca, E. C., Jr., Science of Synthesis Knowledge Updates, (2022) 1, 178. 摘要:Santana, V. C. S.; Munaretto, L. S.; de Lucca, E. C., Jr., Science of Synthesis Knowledge Updates, (2022) 1, 165. 摘要:Mukherjee, S., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 236.