CAS: 2868-48-6; (R)-Methyl 4-((3R,5R,6S,8S,9S,10R,13R,14S,17R)-3,6-Dihydroxy-10,13-Dimethylhexadecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)Pentanoate

上下游产品

methanol diazomethane Hyodeoxycholic Acid dimethyl sulfate3α-oxo-6α-hydroxy-5β-cholan-24-oic acid methyl ester methyl 3α,6α-ditosyloxy-5β-cholan-24-oate (R)-4-((3R,5R,6S,8S,9S,10R,13R,14S,17R)-3,6-Dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid amide 3β-hydroxy-5-cholenoic acid

📜猪去氧胆酸置于甲醇,Ion Exchanger-Resin体系中,化学反应生成猪去氧胆酸甲酯
参考文献:Corbellini Et Al.,Gazzetta Chimica Italiana,1955,Vol. 85,P. 1487,1491
标题:Corbellini Et Al.,Gazzetta Chimica Italiana,1955,Vol. 85,P. 1487,1491

专利信息

专利号:US-4226770-A
优先权日:1978-02-10
标题:Synthesis of steroids
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:The synthesis of 1α,25-dihydroxycholesterol, 1α,25-dihydroxy-7-dehydrocholesterol and 1α,25-dihydroxycholecalciferol and other sterol derivatives from bile acids. Also the synthesis of 3,6-diketo steroids useful in the production of 1α,25-dihydroxycholesterol and other sterols which are biologically active or can be converted to biologically active sterols. The invention involves the sterols so produced and the processes by which they are prepared.

专利号:US-4354972-A
优先权日:1981-06-29
标 题 :Synthesis of steroids
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:This invention relates to the synthesis of steroids which are useful for their biological activity or which may be converted to steroids which have such activity. These syntheses include the steroid compounds and processes for their preparation. n An object of the invention is to provide syntheses which are applicable to materials which are readily available in good supply for converting such materials to steroids which are useful and desirable in the manufacture of pharmaceutical products. n More particularly, I have sought to discover processes and intermediate compounds useful in the synthesis of 24, 25-dihydroxycholesterol from hyodeoxycholic acid or lithocholic acid which are constituents of, and readily available from, animal bile.

专利号:US-4217279-A
优先权日:1978-12-18
标 题 :Synthesis of steroids
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:The synthesis of 25-hydroxycholesterol and 1α,25-dihydroxycholesterol in which the sterol nucleus of an ester of hyodeoxycholic acid is stabilized by protection of the 3 and 6α-hydroxyl groups with alkyl groups, alkyl ether groups, preferably with the 3β-methoxyethoxymethyl group or with the heterocyclic 2-tetrahydropyran group, then extending the chain from the carbon at the 24-position to a cyanide group at the 25-position and then subjecting the sterol so formed to a series of reactions by which it is transformed into 1α,25-dihydroxycholesterol or by a modified series of reactions to 25-hydroxycholesterol.

专利号:GB-2038833-A
优先权日:1978-12-18
标题:Synthesis of 25-hydroxycholesterol from esters of hyodeoxycholic acid

专利号:JP-S588099-A
优先权日:1981-06-29
标题:Synthesis of 24,25-dihydroxycholesterol

专利号:CA-1141372-A
优先权日:1978-12-18
标 题:Synthesis of steroids