CAS: 28443-50-7; 2-Amino-5-Chlorophenol

该化合物是一种氯化芳香化合物,由氨基和羟基功能组组成,成为有机合成的多用途中间体,其分子结构(C6H6ClNO)能够应用于制药,农用化学品和染料制造,该化合物在受控条件下在极地溶剂中表现出中等溶解性和稳定性,有助于将其用于混合反应和作为热循环化合物的前体,其氯替代可增强电益芳烃替代中的再活动,而氨基组则允许进一步衍生.适当处理对于光和空气的潜在敏感性至关重要.适合研究和工业用途,符合合成应用的标准纯度要求.

结构式图片

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611-07-4 56962-00-6 28443-57-4

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REACH注册ECHA物质C&L通报REACH预注册

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合成工艺路线路线简述

    N-(4-氯-2-羟基苯基)乙酰胺置于盐酸体系中,化学反应生成2-氨基-5-氯苯酚
    参考文献:Benzoxazole Derivatives. I. 2-Mercaptobenzoxazoles
    标题:Benzoxazole Derivatives. I. 2-Mercaptobenzoxazoles
    摘要:
    Doi:10.1021/jo01370A010

    海关参考信息

    专利信息


    专利号:US-2016194279-A1
    优先权日:2012-12-09
    标 题 :One pot process for the conversion of aroyl chlorides to acyl thioureas
    发明人:CHEPURI VENKATA RAMANA; BEERAN SENTHILKUMAR
    权利人:COUNCIL SCIENT IND RES
    摘要:The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of formula (I) wherein, R′ is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R″ and R′″ are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.

    专利号:EP-0479161-A1
    优先权日:1990-10-01
    标题:Synthesis of heterocyclic compounds
    发明人:PERRY ROBERT JAMES
    权利人:EASTMAN KODAK CO
    摘要:A new synthetic method is reported in which 2-arylbenz(ox,imid,thi)azoles can be prepared by the palladium catalyzed condensation of aromatic halides with o-amino(phenol, aniline, thiophenol)s followed by dehydrative cyclization. This method is tolerant of a wide variety of functional groups on either aromatic ring and gives good to excellent yields of products.

    专利号:WO-2010048514-A1
    优先权日:2008-10-23
    标题:Synthesis of 2-aminobenzoxazole compounds

    专利号:CA-2051518-A1
    优先权日:1990-10-01
    标 题 :Synthesis of heterocyclic compounds

    专利号:WO-2024126786-A1
    优先权日:2022-12-15
    标 题 :Process for preparing allylic alcohol
    发明人:BONOMO LUCIA; JACOBY DENIS; ARBICHA PASCAL; FONTENY FABIEN; KELLER FABRICE
    权利人:FIRMENICH & CIE
    摘要:The present invention relates to the field of organic synthesis and more specifically it concerns a process for the rearrangement of epoxides into allylic alcohols in a presence of zinc catalyst and two amino phenol.

    专利号:US-12152038-B2
    优先权日:2017-09-05
    标 题:Vasopressin receptor antagonists and products and methods related thereto
    发明人:JONES ROBERT M; URBANO MARIANGELA; BRANDT GARY; CHAMBERS MARK; HARDICK DAVID; KNIGHT CHRIS; TIERNEY JASON; LOCK CHRIS
    权利人:NEUMORA THERAPEUTICS INC
    摘要:Compounds are provided that antagonize vasopressin receptors, particularly the V1a receptor products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof:wherein Q1, Q2, Q3, R2a, R2b, R3 and X are as defined herein.
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    主要参考文献

    [参考文献]: A Schenzle, Et Al. Chemoselective Nitro Group Reduction And Reductive Dechlorination Initiate Degradation Of 2-Chloro-5-Nitrophenol By Ralstonia Eutropha Jmp134. Appl Environ Microbiol. 1999 Jun;65(6):2317-23.
    [参考文献]: E Katsivela, Et Al. Initial Reactions In The Biodegradation Of 1-Chloro-4-Nitrobenzene By A Newly Isolated Bacterium, Strain Lw1. Appl Environ Microbiol. 1999 Apr;65(4):1405-12.
    [参考文献]: G O Rankin, Et Al. Nephrotoxic Potential Of 2-Amino-5-Chlorophenol And 4-Amino-3-Chlorophenol In Fischer 344 Rats: Comparisons With 2- And 4-Chloroaniline And 2- And 4-Aminophenol. Toxicology. 1996 Apr 15;108(1-2):109-23.
    [参考文献]: Jian-Feng Wu, Et Al. Novel Partial Reductive Pathway For 4-Chloronitrobenzene And Nitrobenzene Degradation In Comamonas Sp. Strain Cnb-1. Appl Environ Microbiol. 2006 Mar;72(3):1759-65.
    [参考文献]: M Valentovic, Et Al. 2-Amino-5-Chlorophenol Toxicity In Renal Cortical Slices From Fischer 344 Rats: Effect Of Antioxidants And Sulfhydryl Agents. Toxicol Appl Pharmacol. 1999 Nov 15;161(1):1-9.

    合成参考文献


    参考文献:10.1006/taap.1999.8784
    摘要:Valentovic M, Meadows MK, Harmon RC, Ball JG, Hong SK, Rankin GO. 2-Amino-5-chlorophenol toxicity in renal cortical slices from Fischer 344 rats: effect of antioxidants and sulfhydryl agents. Toxicol Appl Pharmacol. 1999 Nov 15;161(1):1–9. doi: 10.1006/taap.1999.8784.
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