CAS: 25031-08-7; Pivaloyloxymethyl 6-Aminopenicilanate

英文名称Pivaloyloxymethyl 6-Aminopenicilanate
中文名称[(2,2-二甲基丙烷酰基)氧基]甲基6-氨基-3,3-二甲基-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-羧酸酯
IUPAC名称(pivaloyloxy)methyl (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
其它别名Pivaloyloxymethyl 6-Aminopenicilanate; 6-Aminopenicillanic Acid Pivaloyloxymethyl Ester; 6-Amino-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid Hydroxymethyl Pivalate Ester; Pivmecillinam Ep Impurity A; 4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid, 6-Amino-3,3-Dimethyl-7-Oxo-, (2,2-Dimethyl-1-Oxopropoxy)Methyl Ester, [2S-(2α,5α,6β)]- (9Ci); Pivmecillimepimpuritya; Pivmecillinam Hydrochloride Ep Impurity A; Pivmecillinam Hydrochloride Ep Impurity
CAS编号25031-08-7
分子式:C14H22N2O5S分子量:330.41
产品CID: 1204624
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: JMTFSKONGWQPEC-KHQFGBGNSA-N
InChI=1S/C14H22N2O5S/c1-13(2,3)12(19)21-6-20-11(18)8-14(4,5)22-10-7(15)9(17)16(8)10/h7-8,10H,6,15H2,1-5H3/t7-,8+,10-/m1/s1
计算化学: 氢键受体数7.0氢键供体数1.0可旋转键数6.0

MSDS等安全信息

上下游产品

6-Aminopenicillanic Acid Chloromethyl pivalateN-cyano-benzimidoyl)-amino]-penicillanic acid 2,2-dimethyl-propionyloxymethyl ester6β-[(N-cyano-benzimidoyl)-amino]-penicillanic acid 2,2-dimethyl-propionyloxymethyl ester N-cyano-2-phenyl-acetimidoyl)-amino]-penicillanic acid 2,2-dimethyl-propionyloxymethyl ester6β-[(N-cyano-2-phenyl-acetimidoyl)-amino]-penicillanic acid 2,2-dimethyl-propionyloxymethyl ester N-cyano-acetimidoyl]-amino}-penicillanic acid 2,2-dimethyl-propionyloxymethyl ester6β-{[2-(4-chloro-phenyl)-N-cyano-acetimidoyl]-amino}-penicillanic acid 2,2-dimethyl-propionyloxymethyl ester 3-Methyl-2-[(3R,4R)-2-oxo-3-(2-oxo-propyl)-4-phenylacetylsulfanyl-azetidin-1-yl]-but-2-enoic acid 2,2-dimethyl-propionyloxymethyl ester

合成工艺路线路线简述

合成目标产物 Pivaloyloxymethyl 6-Aminopenicilanate 主要起始原料 6-Aminopenicillanic Acid And Chloromethyl Pivalate
(文献来源)合成步骤主要原料 6-Aminopenicillanic Acid 和 Chloromethyl Pivalate

📜6-氨基青霉烷酸,特戊酸氯甲酯置于三乙胺体系中,用 N,N-二甲基甲酰胺用作溶剂,化学反应生成[(2,2-二甲基丙烷酰基)氧基]甲基6-氨基-3,3-二甲基-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-羧酸酯
参考文献:Studies On Lactams. Vii. 6-Isothiocyanatopenicillanate And 7-Isothiocyanatodeacetoxycephalosporanate And Their Reactions.
标题:Studies On Lactams. Vii. 6-Isothiocyanatopenicillanate And 7-Isothiocyanatodeacetoxycephalosporanate And Their Reactions.
摘要:制备了6-异硫氰基青霉烷酸酯和7-异硫氰基去乙酰氧基头孢菌素酸酯,因为它们是合成青霉素和头孢菌素衍生物的有价值的中间体.当用这些异硫氰酸酯化合物进行反应时,得到了与二环己基碳二亚胺的加成产物,这是意外的副产物.所得到的异硫氰酸酯衍生物经与苄胺处理后,得到青霉烷酸衍生物.
Doi:10.1248/cpb.26.1688