CAS: 2052-06-4; 4-Bromo-N,N-Diethylaniline

上下游产品

1.4-dibromobenzene lithium diethylamide acetone N,N-diethylaniline N-tert-Butyl-N-(4-diethylamino-phenyl)-hydroxylamine 4-(diethylamino)benzoic acid 4-Brom-N,N-diethyl-N-methylanilinium-bromid 4-bromo-N,N-dimethylaniline

📜N,N-二乙基苯胺置于oxone,Copper(Ll) Bromide体系中,用 乙腈 用作溶剂,化学反应 3.0H,以65%的收率获得4-溴-N,N-二乙基苯胺
参考文献:一种简便,使用的cubr的芳族胺的区域选择性和可控的溴化2 /过硫酸氢钾®系统†
标题:一种简便,使用的cubr的芳族胺的区域选择性和可控的溴化2 /过硫酸氢钾®系统†
摘要:溴化铜和 环氧酮®用作芳香胺溴化的简便,温和有效的试剂.伯,仲和叔芳族胺都是合适的底物.该反应具有高的区域选择性和官能团耐受性,并且可以可控制地以中等至优异的收率获得单溴和多溴产物.
Doi:10.1039/c3Ra41664J

专利信息

专利号:US-4255578-A
优先权日:1978-11-02
标题 :Synthesis of perhalomethylcarbinol-substituted phenol and naphthol sulfamphthalein dyes from the corresponding triacylated derivatives
发明人：CINCOTTA LOUIS; FOLEY JAMES W
权利人:POLAROID CORP
摘要:The present invention is concerned with a method of synthesizing certain ##STR1## 3-disubstituted sulfam(na)phthalein compounds useful as pH-sensitive indicator dyes and with intermediates useful in the preparation of said compounds. The subject method comprises (1) reacting (a) a 3,3-disubstituted sulfam(na)phthalein wherein one of the 3-substituents is a 4'-hydroxy-1'-phenyl moiety or a 4'-hydroxy-1'-naphthyl moiety substituted in the 3'-position with a perhalomethylcarbinol group and (b) an acid halide, ##STR2## wherein R is alkyl or aryl to give (c) an acylated intermediate wherein the N atom of the sulfam(na)phthalein ring and the 4'-hydroxy and carbinol hydroxy groups are acylated with ##STR3## and (2) treating said compound (c) with alkali to selectively remove said ##STR4## from said hydroxy groups and yield the ##STR5## product. The intermediates of the present invention are the acylated compounds (c).

专利号:US-4178447-A
优先权日:1977-09-23
标 题:Novel synthesis of 3,3-substituted dihydrobenzisothiazole-1,1-dioxides and -2,3-dihydronaphtho-1,2-thiazine-1,1-dioxides
发明人：BORROR ALAN L; FOLEY JAMES W; KAMPE MARCIS M; LEE JOHN W JR
权利人:POLAROID CORP
摘要:This invention relates to a method of synthesizing certain 3-(carbocyclic aryl)-3-(4'-OP-carbocyclic aryl)-2,3-dihydrobenz[d]isothiazole-1,1-dioxides (and -2,3-dihydronaphtho[1,8-de]-1,2-thiazine-1,1-dioxides) by reacting (a) a 4-OP-carbocyclic aryllithium compound wherein P is a protecting group and (b) a 3-(carbocyclic aryl)benz[d]isothiazole-1,1-dioxide wherein said 3-(carbocyclic aryl) moiety is other than a 3-(4'-OP-carbocyclic aryl) moiety to give (c) the corresponding 3-carbocyclic aryl)-3-(4'-OP-carbocyclic aryl)-2,3-dihydrobenz[d]isothiazole-1,1-dioxide. The -2,3-dihydronaphtho[1,8-de]-1,2-thiazine-1,1-dioxides are prepared in the same manner by reacting a 3-(carbocyclic aryl)naphtho[1,8-de]-1,2-thiazine-1,1-dioxide with said 4'-OP-carbocyclic aryllithium compound. n In a further embodiment, the compounds synthesized according to the foregoing method are reacted with a carboxylic acid halide to give the corresponding 2-carbonyl-substituted 2,3-dihydrobenz[d]isothiazole-1,1-dioxide (or -2,3-dihydronaphtho[1,8-de]-1,2-thiazine-1,1-dioxides) followed by removing the protecting group, P, with weak acid to yield certain phenol and 1-naphthol sulfam(na)phthaleins useful, e.g., as optical filter agents and filter agent precursors in photography.

专利号:US-4210752-A
优先权日:1978-11-02
标题 :Synthesis of substituted sulfam(na)phthaleins
发明人：CINCOTTA LOUIS; FOLEY JAMES W
权利人:POLAROID CORP
摘要:The present invention is concerned with synthesizing certain ##STR1## by reacting (a) a 3,3-disubstituted sulfam(na)phthalein wherein one of the 3-substituents is a 4'-hydroxy-1'-phenyl moiety or a 4'-hydroxy-1'-naphthyl moiety substituted in the 3'-position with a perhalomethylcarbinol group and (b) an acid halide, ##STR2## wherein W is chloro or bromo and Y is hydrogen or an electron-withdrawing group, preferably, in the presence of a zeolite molecular sieve or acid alumina to give (c) the corresponding ##STR3## The compounds produced are useful, for example, as pH-sensitive indicator dyes or as photographic light-screening dyes.