CAS: 161511-85-9; (S)-1-Boc-2-Azetidinemethanol
该化合物是一种手性化合物,其特点是有四人组成的环状环状结构,由四人组成,环状环状矿;乙型丁氧碳基(Boc)组是该矿的防护组,可增强该矿的稳定性,促进其在各种合成应用中的使用;该化合物通常用于有机合成,特别是用于开发制药和生物活性分子,因为它有能力作为建筑更复杂结构的建筑块;氢甲基组的存在有助于其再活动,允许其进一步发挥功能;此外,该分子的气质很重要,因为它能够影响该矿的生物活动和由此形成的化合物的相合性.
- 英文名称(S)-1-Boc-2-Azetidinemethanol
- 中文名称(S)-1-BOC-2-氮杂环丁烷甲醇
- IUPAC名称tert-butyl (S)-2-(hydroxymethyl)azetidine-1-carboxylate
- 其它别名1-Azetidinecarboxylicacid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (S)-; (S)-1-(tert-Butoxycarbonyl)-2-azetidinemethanol; (S)-2-Hydroxymethylazetidine-1-carboxylic acid tert-butyl ester; (S)-N-tert-Butoxycarbonyl-2-hydroxymethylazetidine; tert-Butyl(2S)-2-(hydroxymethyl)azetidine-1-carboxylate
- CAS编号161511-85-9
- MFCD编号:MFCD03093620
- EINECS号:840-224-3
- 分子式:C9H17NO3分子量:187.24
- 产品CID: 815434
- 产品分类有机原料 → 醇,酚,酚醇类化合物及衍生物 → 无环醇
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号51077-14-6 1-B°C-L-氮杂环丁烷-2-羧酸 | CAS号209530-92-7 1-AZETIDINECARB...合成工艺路线路线简述
📜1-Boc-L-吖啶-2-羧酸置于dimethyl Sulfide Borane体系中,用 四氢呋喃 用作溶剂,化学反应 1.0H,以93%的收率获得(S)-1-Boc-2-氮杂环丁烷甲醇
参考文献:Mechanistic Interrogation Of The Asymmetric Lithiation-Trapping Of N-Thiopivaloyl Azetidine And Pyrrolidine
标题:Mechanistic Interrogation Of The Asymmetric Lithiation-Trapping Of N-Thiopivaloyl Azetidine And Pyrrolidine
摘要:对s-Buli/手性二胺介导的n-硫代戊酰基氮杂环戊烷和吡咯烷的不对称锂化-捕获机制的基础研究揭示了不对称诱导是由于构型不稳定的有机锂的动态分辨.
Doi:10.1039/c5Cc08690F
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2912110000-甲醛
2915110000-甲酸 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6124474-A
优先权日:1999-12-21
标题 :Synthesis of chiral 2-azetidinemethanol compounds
发明人：HAIGHT ANTHONY R; LALLAMAN JOHN E; WAYNE GREGORY S
权利人:ABBOTT LAB
摘要:A process for preparing chiral isomers of N-protected 2-azetidinemethanol compounds, particularly N-(phenylmethyl)-2-azetidinemethanol and N-BOC-2-azetidinemethanol, and especially the (R)-isomers thereof, as well as O-substituted derivatives thereof.
专利号:US-8329686-B2
优先权日:2006-08-29
标题:Isatin analogues and uses therefor
发明人：MACH ROBERT H; WELCH MICHAEL; CHU WENHUA; ROTHFUSS JUSTIN
权利人:MACH ROBERT H; WELCH MICHAEL; CHU WENHUA; ROTHFUSS JUSTIN; UNIV WASHINGTON
摘要:Novel isatin analogues, including isatin analogues comprising Michael Acceptors (IMAs) are disclosed. Further disclosed are methods of synthesis of the isatin analogues, and uses of the analogues, including inhibition of caspase-3 and caspase-7, and in vivo imaging of apoptosis by Positron emission tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
专利号:EP-1242370-A1
优先权日:1999-12-21
标 题 :Synthesis of chiral 2-azetidinemethanol compounds
专利号:WO-0146135-A1
优先权日:1999-12-21
标 题 :Synthesis of chiral 2-azetidinemethanol compounds
