📜3-溴苯磺酰氯置于甲胺体系中,用 四氢呋喃 用作溶剂,化学反应生成N-甲基-3-溴苯磺酰胺 参考文献:Pyridine Derivatives And Pharmaceutical Compositions Containing Them 标题:Pyridine Derivatives And Pharmaceutical Compositions Containing Them 摘要:这项发明涉及新型吡啶衍生物,其用作药物,含有它们的药物配方以及它们的制备方法.
专利信息
专利号:US-5856497-A 优先权日:1995-12-11 标题 :Asymmetric synthesis of α-cycloalkylalkyl substituted methanamines 发明人:ROTH GREGORY; LANDI JOHN 权利人:BOEHRINGER INGELHEIM PHARMA 摘要:This invention relates to process for asymmetrically producing enantiomerically pure α-cycloalkylalkyl substitututed methanamines from α-pinene. One key step of the process of this invention utilizes the oxidation product of α-pinene, hydroxy pinanone, as a chiral auxiliary to direct the stereoselective alkylation of the corresponding ketimine. This invention also relates to key intermediates useful in the processes referred to herein.
参考文献:10.1055/s-0032-1318315 摘要:Fairley G, Hall C, Greenwood R. Selective Methylation of NH-Containing Heterocycles and Sulfonamides Using N,N-Dimethylformamide Dimethylacetal Based on Calculated pKa Measurements. Synlett. 2013 Feb 25;24(05):570–4. doi: 10.1055/s-0032-1318315.