CAS: 136656-07-0; (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5R,6R)-4,5-Dihydroxy-2-(((2Ar,4S,6As,6Bs,8As,8Br,9S,10R,11As,12As,12Br)-10-Hydroxy-6A,8A,9-Trimethyl-10-((S)-3-Methyl-4-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Butyl)Octadecahydro-1H-Naphtho[2',1':4,5]Indeno[2,1-B]Furan-4-yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3-yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol
该化合物是主要源于以各种生物活动闻名的植物物种Timosaponin植物的沙邦素化合物,其特点是其复杂的甘蓝素结构,通常包括一种与一种或多种糖糖糖相连的类甘酮或三丁基丙酮.这种结构配置有助于其表面活性特性,使其能够与生物膜相互作用.Timosaponin B II已经研究过其潜在的药理效应,包括防炎,防癌和免疫性肺炎活动.此外,它可能对某些癌症细胞线产生细胞毒性效应,使其成为医学化学的一个主题.该化合物在有机溶剂中溶解,并且可能限制了水的溶解性,而许多盐碱都普遍使用这种化合物.其安全特征和潜在的治疗应用在科学研究中继续探索,突出天然产品在药物发现和开发中的重要性.
- 英文名称(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5R,6R)-4,5-Dihydroxy-2-(((2Ar,4S,6As,6Bs,8As,8Br,9S,10R,11As,12As,12Br)-10-Hydroxy-6A,8A,9-Trimethyl-10-((S)-3-Methyl-4-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Butyl)Octadecahydro-1H-Naphtho[2',1':4,5]Indeno[2,1-B]Furan-4-yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3-yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol
- 中文名称知母皂苷 B II
- IUPAC名称(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5R,6R)-4,5-dihydroxy-2-(((2aR,4S,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-10-hydroxy-6a,8a,9-trimethyl-10-((S)-3-methyl-4-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)butyl)octadecahydro-1H-naphtho[2',1':4,5]indeno[2,1-b]furan-4-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
- 其它别名Prototimosaponin Aiiiβ-D-Galactopyranoside,(3β,5β,22α,25S)-26-(β-D-Glucopyranosyloxy)-22-Hydroxyfurostan-3-Yl 2-O-β-D-Glucopyranosyl-
- CAS编号136656-07-0
- MFCD编号:MFCD11111457
- EINECS号:110-062-1
- 分子式:C45H76O19分子量:921.08
- 产品CID: 570012
- 产品分类生物化工 → 中草药成分
物理性质
- 熔点187-189°C
- 沸点1033.6±65.0 °C at 760 mmHg
- 闪点578.9±34.3 °C
- 密度1.5±0.1 g/cm3
- pKa:12.85±0.70(预测)
- PSA:307.37
- LogP:0.34
- 折射率1.627
- 蒸汽压0.0±0.6 mmHg at 25°C
- 溶解性DMF: 30 mg/mL; DMSO: 30 mg/mL; Ethanol: Slightly Soluble; Pbs (Ph 7.2): 5 mg/mL
- 外观形态白色至类白色结晶性固体
- 储存条件室温
- 产品应用该化合物用于治疗阿尔茨海默氏病的氨基质前体蛋白处理的AET-低温调节器. 此外,它与阿内马鲁赫纳磷酸酯的RHIZOME相隔绝,后者在中国传统医学中广泛使用.
MSDS等安全信息
欧盟法规
C&L通报合成工艺路线路线简述
📜在 甲醇,Sodium Methylate体系中,用 二氯甲烷,甲醇 用作溶剂,化学反应 5.0H,以95%的收率获得知母皂苷bii
参考文献: Synthesis Of Timosaponin Bii[fr] Synthèse De Timosaponine Bii
标题: Synthesis Of Timosaponin Bii[fr] Synthèse De Timosaponine Bii
摘要:这项发明提供了从山楂皂苷到泰莫沙皂苷bii及相关化合物的合成途径.提供了一种二酮中间体,可以优点地用于在所需的糖苷末端产物的复杂糖基的原位组装.然后,使用硼氢化还原剂选择性地还原二酮化合物,形成所需的最终产物,其中某些最终产物和中间体是新颖的化合物.
海关参考信息
- 2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905399001-1,3-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:CA-2722798-A1
优先权日:2008-04-30
标题:Synthesis of timosaponin bii
专利号:EP-2274317-A4
优先权日:2008-04-30
标题 :SYNTHESIS OF TIMOSAPONINE BII
专利号:WO-2009132478-A1
优先权日:2008-04-30
标 题 :Synthesis of timosaponin bii
专利号:WO-2009133401-A1
优先权日:2008-04-30
标 题 :Synthesis of timosaponin bii
专利号:US-2011054156-A1
优先权日:2008-04-30
标 题 :Synthesis of timosaponin bii
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Xiao L, Zhang X, Chen Z, Li J, Li B, Li L. Molecular Pathways Involved in Promoting Activity of Timosaponin BII on Hair Growth in C57BL/6 Mice. Biomed Res Int. 2020 Sep 18;2020:9451596. doi: 10.1155/2020/9451596.
2: Xiao L, Zhang X, Chen Z, Li B, Li L. A Timosaponin B-II containing scalp care solution for improvement of scalp hydration, dandruff reduction and hair loss prevention: A comparative study on healthy volunteers before and after application. J Cosmet Dermatol. 2020 Aug 11. doi: 10.1111/jocd.13672. Epub ahead of print.
77:153284. doi: 10.1016/j.phymed.2020.153284. Epub ahead of print. 75(5):201-204. doi: 10.1691/ph.2020.9869. 58(6):494-503. doi: 10.1093/chromsci/bmaa012. 17(4):e1900684. doi: 10.1002/cbdv.201900684. Epub 2020 Apr 3.
合成参考文献
参考文献:10.5281/zenodo.5794106
摘要:The LOTUS Initiative for Open Natural Products Research: frozen dataset union wikidata (with metadata) | DOI:10.5281/zenodo.5794106
📝 需求与反馈
尽可能描述清楚需求与问题信息
