CAS: 130723-13-6; 1-Bromo-3-Fluoro-5-(Trifluoromethyl)Benzene

相似化合物

627526-90-3 401-78-5 240122-25-2

3-氟-5-溴苯酚置于bis(1,5-Cyclooctadiene)Nickel (0),三乙胺,三甲基膦体系中,用 1,4-二氧六环,二氯甲烷 用作溶剂,化学反应 9.17H,反应生成3-溴-5-氟三氟甲苯
参考文献:通过 Ar-O 和 Ar-Cl(Br) 键的化学选择性断裂,镍介导的氯化和溴化苯酚衍生物的发散性三氟甲基化
标题:通过 Ar-O 和 Ar-Cl(Br) 键的化学选择性断裂,镍介导的氯化和溴化苯酚衍生物的发散性三氟甲基化
摘要:我们在此报道了镍介导的氯化和溴化苯酚衍生物 Clarots 和 Brarotf 的三氟甲基化通过 Ar-O 键的化学选择性断裂得到氯(溴)三氟甲基芳烃.此外,在相似的反应条件下,Claropiv和brarots的ar-Cl和ar-Br键发生化学选择性三氟甲基化,得到三氟甲基化苯酚衍生物.
Doi:10.1021/acs.Orglett.4C03020

专利信息

专利号:US-6403793-B2
优先权日:2000-06-12
标 题 :Intramolecular glycosidation process for the synthesis of (2R, 2-alpha-R, 3a)-2-[1-(3,5- bis (trifluoromethyl) phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine
发明人：PYE PHILIP J; ROSSEN KAI
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R-cis)-2-[[1-[3.5-bis(trifluoromethyl)phenyl]ethenyl]oxy]-3-(4-fluorophenyl)-4-(phenylmethyl) mopholine. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-6255545-B1
优先权日:1999-06-11
标 题 :Process for the synthesis of 3,5-bis(trifluoromethyl)-bromobenzene
发明人：CVETOVICH RAYMOND; TSAY FUH-RONG
权利人:MERCK & CO INC
摘要:The present invention is concerned with a novel process for the preparation of 3,5-bis(trifluoromethyl)bromobenzene (CAS 328-70-1). This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-6350915-B1
优先权日:1999-06-11
标 题:Process for the synthesis of 1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-one
发明人：CVETOVICH RAYMOND
权利人:MERCK & CO INC
摘要:The present invention is concerned with a novel process for the preparation of 1-(3,5-bis(trifluromethyl)phenyl)ethan-1-one (CAS 30071-93-3). This compound is useful as an intermediate in the synthesis of therapeutic agents.

专利号:US-6395898-B1
优先权日:2000-06-09
标 题:Trans-glycosidation process for the synthesis of (2R, 2-alpha-R, 3a)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine
发明人：MCNAMARA JAMES M; ZHAO MATTHEW M
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R, 2-alpha-R, 3a)-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy-3-(4-fluorophenyl)-1,4-oxazine. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-7164018-B2
优先权日:2001-01-29
标 题 :Polymers based on N-carbamyl-N'-dimethylsilyl methyl-piperazine traceless linkers for the solid phase synthesis of phenyl based libraries
发明人：CEREDA ENZO; PELLEGRINI CARLO MARIA; QUAI MONICA; BARBAGLIA WALTER
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention relates to polymers characterized by novel silicon linkers based on the carbamyl piperazine moiety, methods of preparing these polymers and their use in the solid phase synthesis of compounds or libraries of compounds embracing a phenyl ring in their structure.

专利号:US-8008504-B2
优先权日:2005-06-09
标题 :Process for the synthesis of organic compounds
发明人：ABEL STEPHAN; ACEMOGLU MURAT; ERB BERNHARD; KRELL CHRISTOPH; SCLAFANI JOSEPH; MEISENBACH MARK; PRASHAD MAHAVIR; SHIEH WEN-CHUNG; XUE SONG
权利人:NOVARTIS AG
摘要:The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is a key intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II):