CAS: 128427-10-1; (S)-N-Boc-2-Aminobutane-1,4-Diol

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(4S)-Benzyl N-(Tbutoxycarbonyl)-Azetidin-2-One-4-Carboxylate置于cp*rucl{(C6H5)2P-(Ch2)2Nh2-κ2-P,N},Potassium Tert-Butylate,氢气体系中,用 叔丁醇 用作溶剂,80.0 °C,3.0 Mpa 条件下,反应 24.0H,以99%的收率获得(S)-2-Boc-氨基-1,4-丁醇
参考文献:双官能[cp * Ru(pn)]配合物催化的n-酰基氨基甲酸酯和n-酰基磺酰胺的加氢反应
标题:双官能[cp * Ru(pn)]配合物催化的n-酰基氨基甲酸酯和n-酰基磺酰胺的加氢反应
摘要:Cp 1的唤醒:双功能配合物1促进了与具有比酮,环氧化物和酰亚胺少的亲电子碳原子的底物的相互作用.该标题反应适用于将埃文斯的不对称烷基化产物还原为手性醇,以及非常好的手性恶唑烷酮助剂的回收率.Ewg =吸电子基团.
Doi:10.1002/anie.200805307

专利信息

专利号:US-6787668-B2
优先权日:2000-04-13
标 题 :2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
发明人：PITZELE BARNETT S; SIKORSKI JAMES A; WEBBER RONALD KEITH
权利人:PHARMACIA CORP
摘要:The present invention is directed to a compound of formula I:or a pharmaceutically acceptable salt thereof, wherein:R1 is selected from the group consisting of H and methyl; andR2 is selected from the group consisting of H and methyl.The compounds possess useful nitric oxide synthetase inhibiting activity, and are expected to be useful in the treatment or prophylaxis of a disease or condition in which the synthesis or over synthesis of nitric oxide forms a contributory part.