CAS: 112110-07-3; 5-(Trifluoromethyl)Pyridin-3-Amine

相似化合物

1187055-61-3 899898-94-3 1414958-36-3

上下游产品

3-chloro-5-(trifluoromethyl)pyridine 2-chloro-3-nitro-5-(trifluoromethyl)pyridine 2-chloro-5-nitro-3-(trifluoromethyl)pyridine 3-bromo-5-(trifluoromethyl)pyridine 2,6-bis(diethylaminomethyl)-4-(7'-trifluoromethyl-1',5'-naphthyridin-4'-ylamino)phenol 2,6-bis(pyrrolidin-1'-ylmethyl)-4-(7''-trifluoromethyl-1'',5''-naphthyridin-4''-ylamino)phenol 2,6-bis(dipropylaminomethyl)-4-(7'-trifluoromethyl-1',5'-naphthyridin-4'-ylamino)phenol 2,6-bis(piperidin-1'-ylmethyl)-4-(7''-trifluoromethyl-1'',5''-naphthyridin-4''-ylamino)phenol

2-氯-3-硝基-5-(三氟甲基)吡啶置于钯 氮体系中,用 甲醇 用作溶剂,化学反应 1.5H,以to Give A Crude Product (1.08 G) Which的收率获得5-三氟甲基-3-氨基吡啶
参考文献:3-Aminocyclopentanecarboxamides As Modulators Of Chemokine Receptors
标题:3-Aminocyclopentanecarboxamides As Modulators Of Chemokine Receptors
摘要:本发明涉及式i的化合物:它们是趋化因子受体的调节剂.本发明的化合物及其组合物在治疗与趋化因子受体表达和/或活性相关的疾病方面具有用途.

专利信息

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:WO-9948868-A9
优先权日:1998-03-26
标 题 :Heterocyclic classes of compounds for the modulating tyrosine protein kinase
发明人：FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
权利人:SUGEN INC; UNIV NEW YORK; MAX PLANCK INST FUR BIOCHEMIE; FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
摘要:The invention relates to certain indolinone-based and pyrazolylamide-based compounds, their method of synthesis, and combinatorial libraries consisting of the compounds. The invention also relates to methods of modulating the function of protein kinases using these compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.