CAS: 104375-88-4; 1-((2R,4S,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-Hydroxytetrahydrofuran-2-yl)-5-Iodopyrimidine-2,4(1H,3H)-Dione

相似化合物

23669-79-6 40615-39-2 146954-74-7

上下游产品

4,4'-dimethoxytrityl chloride 5-Iodo-2'-deoxyuridine (MeO)2Tr-OAc 4,4'-dimethoxytrityl alcohol 5-(3-trifluoroacetamidopropargyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine 5'-O-(4,4'-dimethoxytrityl)-5-formyl-2'-deoxyuridine (N,N-diisopropylamino)methoxyphosphine5'-(4,4'-dimethoxytrityl)-5-iodo-2'-deoxy-3'-uridinyl(N,N-diisopropylamino)methoxyphosphine 1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-(3-trimethylsilanyl-prop-1-ynyl)-1H-pyrimidine-2,4-dione

📜2-脱氧尿苷置于吡啶,4-二甲氨基吡啶,Ammonium Cerium (Iv) Nitrate,碘体系中,用 乙腈 用作溶剂,化学反应 4.0H,反应生成5-O-(二甲氧基三苯甲游基)-5-碘-2-脱氧尿苷
参考文献:固相dna寡聚化的配有互补碱基的亚磷酰胺单体的合成.
标题:固相dna寡聚化的配有互补碱基的亚磷酰胺单体的合成.
摘要:我们描述了两个单体的制备,该单体在边缘带有互补的碱基(鸟嘌呤2'-脱氧胞苷和2-氨基腺嘌呤-2'-脱氧尿苷),并且可以方便地保护和活化以进行固相自动dna合成.我们报告了优化的合成途径,导致涉及的四个核碱基衍生物,它们交叉偶联反应成含二核碱基的单体,以及它们在dna合成仪中的低聚.
Doi:10.1021/acs.Orglett.9B03801

专利信息

专利号:US-6288221-B1
优先权日:1998-08-20
标 题 :Methods of synthesis of halogen base-modified oligonucleotides and subsequent labeling with a metal-catalyzed reaction
发明人：GRINSTAFF MARK W; BEILSTEIN AMY E; KHAN SHOEB I
权利人:UNIV DUKE
摘要:The present invention provides metal-containing purines, pyrimidines, nucleosides, nucleotides and oligonucleotides; including phosphoramidite and photolabile derivatives thereof, including methods of making and method of using same. The present invention provides a method for detection of nucleic acid sequences via electrochemical or photochemical means.

专利号:US-11180523-B2
优先权日:2016-01-04
标 题 :Design, synthesis and use of synthetic nucleotides comprising charge mass tags
发明人：O'HALLORAN JONATHAN J; HEDLEY JOSEPH H
权利人:QUANTUMDX GROUP LTD
摘要:Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.

专利号:US-10759824-B2
优先权日:2008-09-03
标题:Design, synthesis and use of synthetic nucleotides comprising charge mass tags
发明人：O'HALLORAN JONATHAN; HEDLEY JOSEPH H
权利人:QUANTUMDX GROUP LTD
摘要:Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.

专利号:US-2019004055-A1
优先权日:2008-09-03
标 题 :Design, synthesis and use of synthetic nucleotides comprising charge mass tags

专利号:US-10273261-B2
优先权日:2008-09-03
标 题 :Design, synthesis and use of synthetic nucleotides comprising charge mass tags

专利号:US-2016139133-A1
优先权日:2008-09-03
标 题 :Design, synthesis and use of synthetic nucleotides comprising charge mass tags