CAS: 877593-11-8; Tert-Butyl (3-(Hydroxymethyl)Pyridin-2-yl)Carbamate
该化合物是一种有机化合物,其特点是氨基化合物功能组.该物质具有丙烯酯环的特点,有助于其芳香特性和潜在的生物活动.氢氧化硫组的存在会增加其在极地溶剂中的溶解性,并可能影响其再活动.乙基丁基酯组会提供阻碍,从而影响化合物与生物目标的相互作用及其总体稳定性.一般而言,此类氨基乙酸酯在制药和农用化学品中的用途是已知的,通常作为酶抑制剂或合成途径中的中间体.该化合物的具体特性,如熔点,沸点和溶解性,将取决于其分子结构和功能组的存在.安全和处理考虑是必不可少的,因为氨基甲酯根据其结构和浓度,可以产生毒性.
- 英文名称Tert-Butyl (3-(Hydroxymethyl)Pyridin-2-yl)Carbamate
- 中文名称3-羟甲基嘧啶-2-氨基甲酸叔丁酯
- IUPAC名称tert-butyl (3-(hydroxymethyl)pyridin-2-yl)carbamate
- 其它别名(3-羟基甲基吡啶-2-基)氨基甲酸叔丁酯; (3-Hydroxymethyl-Pyridin-2-yl)-Carbamic Acid Tert-Butyl Ester
- CAS编号877593-11-8
- MFCD编号:MFCD04035601
- 分子式:C11H16N2O3分子量:224.26
- 产品CID: 1886208
- 产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物
相似化合物
23612-57-9 32399-12-5 138343-75-6物理性质
MSDS等安全信息
上下游产品
CAS号912369-42-7 3-(B°C-氨基)吡啶甲酸甲酯 | CAS号873460-09-4 2-tert-butoxyca... | CAS号877593-10-7 methyl 2-[bis(t... | CAS号5345-47-1 2-氨基烟酸 | CAS号14667-47-1 2-氨基吡啶-3-甲酸甲酯合成工艺路线路线简述
- 合成目标产物 (3-Hydroxymethyl-Pyridin-2-yl)-Carbamic Acid Tert-Butyl Ester 主要起始原料 3-Pyridinecarboxylic Acid, 2-[bis[(1,1-Dimethylethoxy)Carbonyl]Amino]-, Methyl Ester
- 5345-47-1 = 877593-11-8
反应条件:1.1 Catalysts: Sulfuric Acid Solvents: Methanol,Water; Rt; 20 H,Reflux2.1 Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; 48 H,Rt3.1 Reagents: Lithium Aluminum Hydride Solvents: Tetrahydrofuran; 2 H,0 °C; 0 °C -> 23 °C; 30 Min,23 °C
标题:Azaindole Synthesis Through Dual Activation Catalysis With N-Heterocyclic Carbenes
作者:Sharma,Hayden A.; Et Al
参考文献:Chemical Communications (Cambridge 日期:2016 卷标:52(59) 页码:9283-9286]
877593-10-7 = 877593-11-8
反应条件:1.1 Reagents: Lithium Aluminum Hydride Solvents: Tetrahydrofuran; 2 H,0 °C; 30 Min,Rt1.2 Reagents: Ethanedioic Acid,Potassium Sodium Salt (1:1:1) Solvents: Water
标题:Preparation And Chemical Behavior Of 2-(Tert-Butoxycarbonyl)Amino-3-Bromomethyl Pyridine,A Novel Alkylating Agent
作者:Krasavin,Mikhail; Et Al
参考文献:Synthetic Communications 日期:2006 卷标:36(2) 页码:181-186]
877593-10-7 = 877593-11-8
反应条件:1.1 Reagents: Lithium Aluminum Hydride Solvents: Tetrahydrofuran; 2 H,0 °C; 0 °C -> 23 °C; 30 Min,23 °C
标题:Azaindole Synthesis Through Dual Activation Catalysis With N-Heterocyclic Carbenes
作者:Sharma,Hayden A.; Et Al
参考文献:Chemical Communications (Cambridge 日期:2016 卷标:52(59) 页码:9283-9286]
24424-99-5 + 14667-47-1 = 877593-11-8
反应条件:1.1 Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; 48 H,Rt2.1 Reagents: Lithium Aluminum Hydride Solvents: Tetrahydrofuran; 2 H,0 °C; 0 °C -> 23 °C; 30 Min,23 °C
标题:Azaindole Synthesis Through Dual Activation Catalysis With N-Heterocyclic Carbenes
作者:Sharma,Hayden A.; Et Al
参考文献:Chemical Communications (Cambridge 日期:2016 卷标:52(59) 页码:9283-9286]
24424-99-5 + 14667-47-1 = 877593-11-8
反应条件:1.1 Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; 36 H,Rt2.1 Reagents: Lithium Aluminum Hydride Solvents: Tetrahydrofuran; 2 H,0 °C; 30 Min,Rt2.2 Reagents: Ethanedioic Acid,Potassium Sodium Salt (1:1:1) Solvents: Water
标题:Preparation And Chemical Behavior Of 2-(Tert-Butoxycarbonyl)Amino-3-Bromomethyl Pyridine,A Novel Alkylating Agent
作者:Krasavin,Mikhail; Et Al
参考文献:Synthetic Communications 日期:2006 卷标:36(2) 页码:181-186]
5345-47-1 = 877593-11-8
反应条件:1.1 Reagents: Sulfuric Acid Solvents: Methanol; 20 H,Reflux1.2 Reagents: Ammonium Hydroxide Solvents: Water; 0 °C2.1 Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; 36 H,Rt3.1 Reagents: Lithium Aluminum Hydride Solvents: Tetrahydrofuran; 2 H,0 °C; 30 Min,Rt3.2 Reagents: Ethanedioic Acid,Potassium Sodium Salt (1:1:1) Solvents: Water
标题:Preparation And Chemical Behavior Of 2-(Tert-Butoxycarbonyl)Amino-3-Bromomethyl Pyridine,A Novel Alkylating Agent
作者:Krasavin,Mikhail; Et Al
参考文献:Synthetic Communications 日期:2006 卷标:36(2) 页码:181-186
📜2-氨基烟酸置于4-二甲氨基吡啶,Lithium Aluminium Tetrahydride,硫酸体系中,用 四氢呋喃,二氯甲烷,水 作为反应溶剂,化学反应 50.5H,反应生成 (3-羟基甲基吡啶-2-基)氨基甲酸叔丁酯
参考文献:Azaindole Synthesis Through Dual Activation Catalysis With N-Heterocyclic Carbenes
标题:Azaindole Synthesis Through Dual Activation Catalysis With N-Heterocyclic Carbenes
摘要:报道了一种由卡宾催化实现的无过渡金属合成2-芳基吡唑吲哚的方法,具有高产率和广泛底物范围,包括以前无法访问的吡唑吲哚.
DOI:10.1039/c6Cc04735A
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2912110000-甲醛
2915110000-甲酸 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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主要参考文献
参考标题:Preparation And Chemical Behavior Of 2‐(Tert‐butoxycarbonyl)Amino‐3‐bromomethyl Pyridine, A Novel Alkylating Agent作者:Mikhail Krasavin,Sergey Shkavrov,Dmitry Kravchenko |发布日期:2006.2.1
摘要:Abstract Synthesis Of A Novel Heterocyclic Alkylating Agent Has Been Developed. Its Instability Toward Elevated Temperatures And/or Polar Media Can Be Used To Prepare 8‐aza‐1,4‐dihydrobenzo[1,3‐d]Oxazin‐2‐one.
合成参考文献
参考DOI号:10.1080/00397910500334371
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