CAS: 85237-65-6; 2-(4-Fluorophenyl)-5-Methylpyridine

该化合物是一种有机化合物,其特点是以氟联苯组和甲基组取代了环,其特征是其环,苯环上存在氟原子,这增强了该化合物的电镀性能,可能影响其在各种化学环境中的再反应和相互作用.该化合物通常表现出黄色到褐色的苍白表面,在有机溶剂中溶解,反映其非极性特征.其分子结构有助于其在制药,农用化学和材料科学方面的潜在应用,特别是在生物活性化合物的开发方面.该化合物独特的替代模式还可能影响其物理特性,如沸点和熔点,以及其光谱特性,因此对进一步研究合成化学和药用化学具有兴趣.在处理和储存方面,应参考安全数据,以便处理和储存所有化学物质.

英文名称2-(4-Fluorophenyl)-5-Methylpyridine
中文名称2-(4-氟苯基)-5-甲基吡啶
IUPAC名称2-(4-fluorophenyl)-5-methylpyridine
其它别名5-Methyl-2-(4-Fluorophenyl)Pyridine; Pyridine,2-(4-Fluorophenyl)-5-Methyl-; Pwa96Kq36T; Pyridine, 2-(4-Fluorophenyl)-5-Methyl-; 2-(4'-Fluorophenyl)-5-Me
CAS编号85237-65-6
MFCD编号:MFCD09037512
EINECS号:286-425-4
FDA UNII编号:PWA96KQ36T
分子式:C12H10FN分子量:187.22
产品CID: 1847608
产品分类医药中间体 → 吡啶类化合物

相似结构搜索
InChIKey: WSVYYUKIXFSDTE-UHFFFAOYSA-N
InChI=1S/C12H10FN/c1-9-2-7-12(14-8-9)10-3-5-11(13)6-4-10/h2-8H,1H3
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数1.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H315-H319
防范说明P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
危险品标志Xi
WGK Germany3

上下游产品

CAS号78-85-3 2-甲基丙烯醛 | CAS号26031-63-0 1-(4-fluorophen... | CAS号403-29-2 2-溴-4'-氟苯乙酮 | CAS号18368-64-4 2-氯-5-甲基吡啶 | CAS号1765-93-1 4-氟苯硼酸

合成工艺路线路线简述

合成目标产物 2-(4-Fluorophenyl)-5-Methylpyridine 主要起始原料 2-Bromo-5-Methylpyridine And 4-Fluorobenzeneboronic Acid
18368-64-4 + 1765-93-1 = 85237-65-6
反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: Ethanol,Toluene,Water; 48 H,Reflux
标题:Synthesis Of Facial Cyclometalated Iridium(Iii) Complexes Triggered By Tripodal Ligands
作者:Moriuchi,Toshiyuki; Mao,Lisheng; Wu,Hsyueh-Liang; Ohmura,Satoshi D.; Watanabe,Masami; Et Al
参考文献:Dalton Transactions 日期:2012 卷标:41(31) 页码:9519-9525]

26031-63-0 = 85237-65-6
反应条件:1.1 Reagents: Ammonium Acetate Solvents: Methanol; 12 H,60 °C
标题:Accelerated Luminophor Discovery Through Combinatorial Synthesis
作者:Lowry,Michael S.; Hudson,William R.; Pascal,Robert A. Jr.; Bernhard,Stefan
参考文献:Journal Of The American Chemical Society 日期:2004 卷标:126(43) 页码:14129-14135]

26031-63-0 = 85237-65-6
反应条件:1.1 Reagents: Ammonium Acetate Solvents: Methanol; Rt -> 65 °C; Overnight,65 °C
标题:Highly Fluorinated Ir(Iii)-2,2':6',2''-Terpyridine-Phenylpyridine-X Complexes Via Selective C-F Activation: Robust Photocatalysts For Solar Fuel Generation And Photoredox Catalysis
作者:Porras,Jonathan A.; Mills,Isaac N.; Transue,Wesley J.; Bernhard,Stefan
参考文献:Journal Of The American Chemical Society 日期:2016 卷标:138(30) 页码:9460-9472]

26031-63-0 = 85237-65-6
反应条件:1.1 Reagents: Methacrolein,Ammonium Acetate Solvents: Methanol; 18 H,Reflux
标题:Heteroleptic Cyclometalated Iridium(Iii) Complexes
作者:Tinker,Leonard L.; Mcdaniel,Neal D.; Cline,Eric D.; Bernhard,Stefan; Putman,Ross D.; Et Al
参考文献:Inorganic Syntheses 日期:2010 卷标:35 页码:168-173]

370878-58-3 = 85237-65-6 + 27012-22-2
反应条件:1.1 Reagents: Lithium Aluminum Hydride Catalysts: Niobium Pentachloride Solvents: 1,2-Dimethoxyethane; Rt -> Reflux; 6.5 H,Reflux; Reflux -> 0 °C1.2 Reagents: Water; 0 °C
标题:Hydrodefluorinations By Low-Valent Niobium Catalyst
作者:Fuchibe,Kohei; Ohshima,Yoshitaka; Mitomi,Ken; Akiyama,Takahiko
参考文献:Journal Of Fluorine Chemistry 日期:2007 卷标:128(10) 页码:1158-1167

📜2-溴-4'-氟苯乙酮置于乙酸铵体系中,用甲醇作为反应溶剂,化学反应 15.0H,反应生成 2-(4-氟苯基)-5-甲基吡啶
参考文献:Accelerated Luminophore Discovery Through Combinatorial Synthesis
标题:Accelerated Luminophore Discovery Through Combinatorial Synthesis
摘要:A Method For Accelerating The Discovery Of Ionic Luminophores Using Combinatorial Techniques Is Reported. The Photophysical Properties Of The Resulting Transition-Metal-Based Chromophores Were Compared Against A Series Of Analogous,Traditionally Prepared Species. The Strong Overlap Between These Two Sets Confirms The Identity Of The Parallel Synthesis Products And Supports The Truthfulness Of The Combinatorial Results. Further Support For The Combinatorial Method Comes From The Adherence Of These Complexes To The Energy Gap Law. The Relationship Between The Structure Of A Complex And Its Photophysical Properties Was Also Considered,And Static Dft Calculations Were Used To Assess Whether It Is Feasible To Predict The Luminescent Behavior Of Novel Materials.
DOI:10.1021/ja047156+