CAS: 81024-43-3; (2R)-1-[4-(2-Methoxyethyl)Phenoxy]-3-(Propan-2-Ylamino)Propan-2-Ol

该化合物是一种选择性的乙1-肾上激素受体阻塞器,主要用于治疗高血压,心血管切质和心脏衰竭.这是一种手性化合物,其(+)指定表明其特定的光学异构体,这是造成其治疗效果的积极形式.该物质通常以酸盐的形式施用,提高溶性性和生物利用率.(+)-Metoproolol表现出一种温和的亲情,允许它跨越血液呼吸屏障,从而导致中...

英文名称(2R)-1-[4-(2-Methoxyethyl)Phenoxy]-3-(Propan-2-Ylamino)Propan-2-Ol
中文名称美托洛尔
其它别名2-Propanol,1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (R)-; (+)-Metoprolol; (R)-(+)-Metoprolol; (R)-Metoprolol
CAS编号81024-43-3
MFCD编号:MFCD00869311
分子式:C15H25NO3分子量:267.36
产品CID: 1804742
产品分类原料药 → 循环系统用药 → 抗心律失常药

相似结构搜索
InChIKey: IUBSYMUCCVWXPE-CQSZACIVSA-N
1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3/t14-/m1/s1
计算化学: 氢键受体数4.0氢键供体数2.0可旋转键数9.0

物理性质

熔点39-42 °C
沸点398.6±37.0 °C at 760 mmHg
闪点194.9±26.5 °C
密度1.0±0.1 g/cm3
pKa:13.89±0.20(预测)
PSA:50.72
LogP:1.79
折射率1.508
蒸汽压0.0±1.0 mmHg at 25°C
溶解性Chloroform (Slightly), Methanol (Slightly)
外观形态浅米色蜡状固体
储存条件-20°C 冰箱, 在惰性气其中

MSDS等安全信息

上下游产品

合成工艺路线路线简述

75-31-0 + 105780-38-9 = 81024-43-3
反应条件:1.1 Catalysts: Borate(1-),Tetrafluoro-,Zinc (2:1),Hydrate; 2 H,Rt
标题:Zinc Tetrafluoroborate Hydrate As A Mild Catalyst For Epoxide Ring Opening With Amines: Scope And Limitations Of Metal Tetrafluoroborates And Applications In The Synthesis Of Antihypertensive Drugs (Rs)/(R)/(S)-Metoprolols
作者:Pujala,Brahmam; Et Al
参考文献:Journal Of Organic Chemistry 日期:2011 卷标:76(21) 页码:8768-8780]

56392-18-8 = 81024-43-3 [标题:Reaction Conditions
标题:Immobilized Cellulase (Cbh I) As A Chiral Stationary Phase For Direct Resolution Of Enantiomers
作者:Erlandsson,Per; Et Al
参考文献:Journal Of The American Chemical Society 日期:1990 卷标:112(11) 页码:4573-4]

126824-46-2 = 81024-43-3
反应条件:1.1 Reagents: Pyridine Solvents: Dichloromethane2.1 Solvents: Acetonitrile
标题:Stereospecific Synthesis Of Specifically Deuterated Metoprolol Enantiomers From Chiral Starting Materials
作者:Shetty,H. Umesha; Et Al
参考文献:Journal Of Labelled Compounds And Radiopharmaceuticals 日期:1989 卷标:27(10) 页码:1215-26]

23788-74-1 + 56718-71-9 = 81024-43-3
反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Ethanol2.1 Reagents: Hydrochloric Acid Solvents: Ethanol3.1 Reagents: Pyridine Solvents: Dichloromethane4.1 Solvents: Acetonitrile
标题:Stereospecific Synthesis Of Specifically Deuterated Metoprolol Enantiomers From Chiral Starting Materials
作者:Shetty,H. Umesha; Et Al
参考文献:Journal Of Labelled Compounds And Radiopharmaceuticals 日期:1989 卷标:27(10) 页码:1215-26]

14140-15-9 = 81024-43-3
反应条件:1.1 Reagents: Sodium Methoxide Solvents: Methanol2.1 Reagents: Potassium Hydroxide Solvents: Ethanol3.1 Reagents: Hydrochloric Acid Solvents: Ethanol4.1 Reagents: Pyridine Solvents: Dichloromethane5.1 Solvents: Acetonitrile
标题:Stereospecific Synthesis Of Specifically Deuterated Metoprolol Enantiomers From Chiral Starting Materials
作者:Shetty,H. Umesha; Et Al
参考文献:Journal Of Labelled Compounds And Radiopharmaceuticals 日期:1989 卷标:27(10) 页码:1215-26]

702-23-8 = 81024-43-3
反应条件:1.1 Reagents: Hydrogen Bromide Solvents: Water2.1 Reagents: Sodium Methoxide Solvents: Methanol3.1 Reagents: Potassium Hydroxide Solvents: Ethanol4.1 Reagents: Hydrochloric Acid Solvents: Ethanol5.1 Reagents: Pyridine Solvents: Dichloromethane6.1 Solvents: Acetonitrile
标题:Stereospecific Synthesis Of Specifically Deuterated Metoprolol Enantiomers From Chiral Starting Materials
作者:Shetty,H. Umesha; Et Al
参考文献:Journal Of Labelled Compounds And Radiopharmaceuticals 日期:1989 卷标:27(10) 页码:1215-26]

75-31-0 = 81024-43-3
反应条件:1.1 Solvents: Acetonitrile
标题:Stereospecific Synthesis Of Specifically Deuterated Metoprolol Enantiomers From Chiral Starting Materials
作者:Shetty,H. Umesha; Et Al
参考文献:Journal Of Labelled Compounds And Radiopharmaceuticals 日期:1989 卷标:27(10) 页码:1215-26]

75-31-0 + 7585-39-9 + 56718-70-8 = 81024-43-3 [标题:Reaction Conditions
标题:Dynamic Kinetic Asymmetric Synthesis Of β-Amino Alcohols From Racemic Epoxides In Cyclodextrin Complexes Under Solid State Conditions
作者:Reddy,L. Rajender; Et Al
参考文献:Chemical Communications (Cambridge) 日期:2000 卷标:(23) 页码:2321-2322]

75-31-0 + 56718-71-9 + 67843-74-7 = 81024-43-3
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol1.2 Solvents: Methanol1.3 Solvents: Methanol
标题:Enantioselective Preparation Of Metoprolol And Its Major Metabolites
作者:Jung,Sang-Hun; Et Al
参考文献:Archives Of Pharmacal Research 日期:2000 卷标:23(3) 页码:226-229]

51594-55-9 + 56718-71-9 = 81024-43-3
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetonitrile; 14 H,Reflux2.1 Catalysts: Borate(1-),Tetrafluoro-,Zinc (2:1),Hydrate; 2 H,Rt
标题:Zinc Tetrafluoroborate Hydrate As A Mild Catalyst For Epoxide Ring Opening With Amines: Scope And Limitations Of Metal Tetrafluoroborates And Applications In The Synthesis Of Antihypertensive Drugs (Rs)/(R)/(S)-Metoprolols
作者:Pujala,Brahmam; Et Al
参考文献:Journal Of Organic Chemistry 日期:2011 卷标:76(21) 页码:8768-8780]

113798-77-9 = 81024-43-3
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Ethanol2.1 Reagents: Pyridine Solvents: Dichloromethane3.1 Solvents: Acetonitrile
标题:Stereospecific Synthesis Of Specifically Deuterated Metoprolol Enantiomers From Chiral Starting Materials
作者:Shetty,H. Umesha; Et Al
参考文献:Journal Of Labelled Compounds And Radiopharmaceuticals 日期:1989 卷标:27(10) 页码:1215-26]

22323-82-6 = 81024-43-3
反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane2.1 Reagents: Potassium Hydroxide Solvents: Ethanol3.1 Reagents: Hydrochloric Acid Solvents: Ethanol4.1 Reagents: Pyridine Solvents: Dichloromethane5.1 Solvents: Acetonitrile
标题:Stereospecific Synthesis Of Specifically Deuterated Metoprolol Enantiomers From Chiral Starting Materials
作者:Shetty,H. Umesha; Et Al
参考文献:Journal Of Labelled Compounds And Radiopharmaceuticals 日期:1989 卷标:27(10) 页码:1215-26]

51384-51-1 = 81024-43-3 + 81024-42-2
反应条件:1.1 Reagents: β-Cyclodextrin,6A,6B,6C,6D,6E,6F,6G-Heptakis-O-(Carboxymethyl)-2A,2B,2C,2D,2E,2...; 20 °C
标题:Characterization Of A Single-Isomer Carboxymethyl-Beta-Cyclodextrin In Chiral Capillary Electrophoresis
作者:Fejos,Ida; Et Al
参考文献:Electrophoresis 日期:2017 卷标:38(15) 页码:1869-1877]

87-69-4 + 51384-51-1 = 81024-43-3 + 81024-42-2 [标题:Reaction Conditions
标题:Enantioseparations Of 11 Amino Alcohols Using Di-N-Amyl L-Tartrate-Boric Acid Complex As Chiral Mobile Phase Additive By Rp-Hplc
作者:Zou,Yanan; Et Al
参考文献:Chromatographia 日期:2015 卷标:78(11-12) 页码:753-761

📜Metoprolol Hydrochloride 反应生成美托洛尔
参考文献:Erlandsson,Per;Marle,Ingrid;Hansson,Lennart;Isaksson,Roland;Pettersso+,J. Amer. Chem. Soc.,112,(1990) N1,C. 4573-4574
标题:Erlandsson,Per;Marle,Ingrid;Hansson,Lennart;Isaksson,Roland;Pettersso+,J. Amer. Chem. Soc.,112,(1990) N1,C. 4573-4574

海关参考信息

2902600000-乙苯
2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-8877930-B2
优先权日:2009-11-04
标题 :Continuous flow synthesis of amino alcohols using microreactors
发明人：BEDORE MATTHEW W; ZABORENKO NIKOLAY; JENSEN KLAVS F; JAMISON TIMOTHY F
权利人:BEDORE MATTHEW W; ZABORENKO NIKOLAY; JENSEN KLAVS F; JAMISON TIMOTHY F; MASSACHUSETTS INST TECHNOLOGY
摘要:The present invention provides various methods for the synthesis of chemical species in a microreactor environment. In some cases, reaction products of the present invention may be valuable as intermediates and/or products in pharmaceutical and polymer research. For example, the method may involve the synthesis of amino alcohols within a microchannel. Embodiment described herein may allow for reactions with significantly shorter reaction times and increased efficiency.

专利号:US-10925977-B2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-9757463-B2
优先权日:2012-06-15
标题 :Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures
发明人：HARTH EVA M; BEEZER DAIN B; LI GUANGZHAO; SPEARS BENJAMIN R; STEVENS DAVID M
权利人:UNIV VANDERBILT
摘要:Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-11078093-B2
优先权日:2017-06-30
标题 :Surfactant-assisted synthesis of surface-functionalized nanoparticle-polymer electrospun composites
发明人：CWIERTNY DAVID; MYUNG NOSANG; PETER KATHERINE T; PARKIN GENE FRANCIS
权利人:UNIV CALIFORNIA; UNIV IOWA RES FOUND
摘要:A method is disclosed for synthesizing nanofilters for water treatment. The method includes: dispersing an active binding agent in an organic solvent solution to create a suspension of the active binding agent and the solution of the solvent; dissolving an organic polymer resin and an anionic surfactant in the suspension of the active binding agent and the solvent solution to create a sol gel; and electrospinning the sol gel to form electrospun nanofiber composites with embedded, surface-active nanoparticles.

专利号:US-2019002309-A1
优先权日:2017-06-30
标题 :Surfactant-assisted synthesis of surface-functionalized nanoparticle-polymer electrospun composites

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合成参考文献

参考文献:10.1007/s11136-011-9968-6
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参考文献:10.1186/1471-2288-11-106
摘要:Ramsay EN, Roughead EE, Ewald B, Pratt NL, Ryan P. A self-controlled case series to assess the effectiveness of beta blockers for heart failure in reducing hospitalisations in the elderly. BMC Medical Research Methodology. 2011 Jul 18;11(1):106. doi: 10.1186/1471-2288-11-106.