CAS: 7529-22-8; 4-Methylmorpholine 4-Oxide

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CAS号109-02-4 N-甲基吗啉 | CAS号72229-10-8 cis-3-bromo-4,5... | CAS号107743-45-3 | CAS号76847-41-1 3-bromo-4,5-dih... | CAS号209350-34-5 N-methyl-N-(2-m... | CAS号110-91-8 吗啉 | CAS号50-00-0 甲醛 | CAS号1227476-15-4 1,2-diphenyldiazene | CAS号495-48-7 氧化偶氮苯 | CAS号27438-39-7 1-(4-吗啉基甲基)-2-萘酚 | CAS号875-51-4 4-溴-2-硝基苯胺 | CAS号58442-17-4 1H-苯并咪唑-5-甲醛 | CAS号98977-36-7 1-B°C-3-哌啶酮 | CAS号1017-73-8 4-(3-phenylprop...

N-甲基吗啉置于5-Ethyl-1,3,7,8-Tetramethylalloxazinium Triflate,双氧水体系中,用 氘代甲醇,水 作为反应溶剂,化学反应生成 N-甲基吗啉氧化物
参考文献:核黄素衍生的黄酮盐用于催化H2O 2氧化的比较†
标题:核黄素衍生的黄酮盐用于催化H2O 2氧化的比较†
摘要:从市场上可买到的核黄素制备了一系列黄酮盐,5-乙基异all杂嗪鎓,5-乙基ethyl杂嗪鎓和1,10-乙烯桥联的四氧嘧啶鎓三氟甲磺酸盐.这项研究提出了它们的光学和氧化还原特性,以及它们在H2O 2中的催化活性之间的比较.硫化物,叔胺和环丁酮的氧化.反映了π-共轭环结构之间的差异,黄酮盐显示出非常不同的氧化还原性质,其还原电位的顺序为:5-乙基异四氮杂鎓> 5-乙基四氧杂鎓> 1,10-乙烯桥联的四氧杂嗪鎓.比较它们的催化活性表明,三氟甲磺酸5-乙基异恶唑嗪能特异性氧化硫化物和环丁酮,而三氟甲磺酸5-乙基异恶唑嗪能平稳地氧化叔胺.1,10-桥联的三氟甲磺酸铝恶唑鎓盐,可以很容易地从核黄素中大量获得,对硫化物和环丁酮的H2O 2氧化表现出中等的催化活性.
DOI:10.1039/c8Ob00856F

专利信息

专利号:US-10995049-B2
优先权日:2019-07-19
标 题 :Total synthesis of prostaglandin J natural products and their intermediates
发明人：LI JIAMING; XU CHEN; AHMED TONIA S; GRUBBS ROBERT H; STOLTZ BRIAN M
权利人:CALIFORNIA INST OF TECHN
摘要:The present disclosure is directed to methods of preparing prostaglandin J natural products by stereoretentive metatheses reactions and intermediates used in the synthesis of these natural products, including the use of intermediates of Formula (I-A), where R 1 is defined in the specification

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:WO-2025053792-A1
优先权日:2023-09-06
标题:Collective synthesis of phantomolin family through total synthesis of the sesquiterpene lactone molephantin
发明人：CHIBA SHUNSUKE; PATOURET REMI HENRI LOUIS; LI HOI YEUNG; LAI SOAK KUAN
权利人:UNIV NANYANG TECH
摘要:Disclosed herein are processes to generate an intermediate in the total synthesis of (+)- molephantin or a derivative thereof, and a total synthesis of (+)-molephantin or a derivative thereof. Also disclosed herein are methods of forming a compound of formula XIV and of forming a compound of formula XV, wherein compound of formula XIV and compound of formula XV are as defined in the description.

专利号:US-2004152905-A1
优先权日:2003-01-31
标题:Universal building blocks and support media for synthesis of oligonucleotides and their analogs
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and chemically modified oligonucleotide analogs, are provided. In addition, methods for functionalization of a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-7344863-B2
优先权日:1998-03-13
标题:Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules
发明人：LI WU-BO; JESSEE JOEL A; SCHUSTER DAVID; XIA JIULIN; GEBEYEHU GULILAT
权利人:INVITROGEN CORP
摘要:The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides compositions comprising one or more nitrogen-containing organic compounds having a formula selected from the group consisting of formula I and formula II (or salts or derivatives thereof), preferably 4-methylmorpholine N-oxide or betaine (carboxymethyltrimethylammonium), and further comprising one or more compounds selected from the group consisting of proline and an N-alkylimidazole compound, and more preferably proline, 1-methylimidazole or 4-methylimidazole. The invention further relates to methods for enhanced, high-fidelity synthesis of nucleic acid molecules, including via amplification (particularly PCR), reverse transcription, and sequencing methods. The invention also relates to nucleic acid molecules synthesized by these methods, to fragments or derivatives thereof, and to vectors and host cells comprising such nucleic acid molecules, fragments, or derivatives. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the compositions of the invention.

专利号:US-2004018598-A1
优先权日:2000-05-30
标题 :Bio-intermediates for use in the chemical synthesis of polyketides
发明人：SANTI DANIEL; ASHLEY GARY; MYLES DAVID C
摘要:The present invention relates to compounds made by a subset of modules from one or more polyketide synthase (“PKSâ€?) genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring polyketides or derivatives thereof. The biologically derived intermediates (“bio-intermediatesâ€?) generally represent particularly difficult compounds to synthesize using traditional chemical approaches due to one or more stereocenters. In one aspect of the invention, an intermediate in the synthesis of epothilone is provided that feeds into the synthetic protocol of Danishefsky and co-workers. In another aspect of the invention, intermediates in the synthesis of discodermolide are provided that feed into the synthetic protocol of Smith and co-workers. By taking advantage of the inherent stereochemical specificity of biological processes, the syntheses of key intermediates and thus the overall syntheses of compounds like epothilone and discodermolide are greaty simplified.