CAS: 677-24-7; Methyl Dichlorophosphate

该化合物是一种有机磷化合物,其化学配方为C2H4Cl2O4P.它看起来是一种无色的黄色液体,其气味极不明显.这种物质因其反应性而闻名,主要用作各种化学品合成的中间体,包括杀虫剂和药品.甲基二氯磷酸酯在有机溶剂中可溶解,但在水中溶解性有限.它被归类为有毒化合物,其潜在的健康危害包括呼吸刺激和接触时对...

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欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

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合成工艺路线路线简述

    📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于三氯氧磷体系中,化学反应生成 二氯磷酸甲酯
    参考文献:Cavers,Journal Of The Chemical Society,1902,Vol. 81,P. 1373
    标题:Cavers,Journal Of The Chemical Society,1902,Vol. 81,P. 1373

    海关参考信息

    专利信息


    专利号:US-7943594-B2
    优先权日:2002-07-10
    标 题 :Solid-phase and solution-phase synthesis of glycosylphosphatidylinositol glycans
    发明人:SEEBERGER PETER H; HEWITT MICHAEL C; SNYDER DANIEL A
    权利人:MASSACHUSETTS INST TECHNOLOGY
    摘要:One aspect of the present invention relates to solution-phase approaches to GPI synthesis. Another aspect of the present invention relates to key building blocks, and syntheses thereof, useful for GPI assembly. Yet another aspect of the invention relates to an automated method for the synthesis of GPIs and fragments thereof.

    专利号:US-7741473-B2
    优先权日:2005-03-30
    标 题 :Process for the preparation of 4,6-disubstituted-tetrahydro-furo, thieno, pyrrolo and cyclopenta-[3,4][1,3]dioxoles
    发明人:WATSON PAUL S; DOUGLASS III JAMES G; SUCHOZAK BOB; PANDIARAJU SUBRAMANIAN; DIXON CRAIG E; LEVIN DANIEL
    权利人:INSPIRE PHARMACEUTICALS INC
    摘要:The present invention is directed to a processes for the synthesis of trans isomer of 4,6-disubstituted-tetrahydro-furo, thieno, pyrrolo and cyclopenta-[3,4][1,3]dioxoles (Formula I). The process comprises the steps of: (a) obtaining a compound of Formula II, which is a mixture of cis and trans-diastereomers, and (b) chemically decomposing the compound of Formula II in a solution comprising a solvent and an acid that is a hydrogen donor or an electron pair acceptor, whereby the cis diastereomer is decomposed and the compound of Formula I is obtained. The compounds prepared by the present invention are useful in treating diseases or conditions associated with platelet aggregation and/or platelet activation.

    专利号:US-8614312-B2
    优先权日:2008-02-21
    标 题 :Method for preparing nucleotides and related analogues by synthesis on soluble substrate, and biological tools thus prepared
    发明人:PEYROTTES SUZANNE; PERIGAUD CHRISTIAN; CRAUSTE CELINE
    权利人:PEYROTTES SUZANNE; PERIGAUD CHRISTIAN; CRAUSTE CELINE; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER II
    摘要:The invention concerns a method for preparing monomer nucleotides or nucleotide analogues comprising the steps of: (1) coupling a soluble polyethylene glycol support provided with at least one diacid or ether-acid linker and a monomer nucleoside or nucleoside analogue to an amine group or hydroxyl group of the nucleoside with the aid of a coupling agent; (2) at least one step for phosphorylation of said nucleoside or nucleoside analogue coupled to said support with a phosphorylation agent; (3) cleavage of said support and recovery of at least one monomer nucleotide or nucleotide analogue. The nucleotides prepared are biological tools.

    专利号:WO-2023040981-A1
    优先权日:2021-09-20
    标 题:Methods and compositions for weight management
    发明人:HUA NG MENG; WANG RUIQI RACHEL; LIANG KUN; ZHENG ZIPENG; YANG JIE
    权利人:AEGOGEN SUZHOU LTD
    摘要:This present application relates to the use of small molecules for weight management, prevention of aging and the treatment of associated conditions and diseases. The present application also provides for the synthesis of some of the molecules and the administration of these molecules for drug discovery, nutrition and cosmeceutical purposes.

    专利号:US-4835263-A
    优先权日:1983-01-27
    标 题 :Novel compounds containing an oligonucleotide sequence bonded to an intercalating agent, a process for their synthesis and their use
    发明人:NGUYEN THANH T; HELENE CLAUDE; ASSELINE ULYSSE
    权利人:CENTRE NAT RECH SCIENT
    摘要:The present invention relates to a chemical compound which consists of an oligonucleotide or an oligodeoxynucleotide consisting of a natural or modified chain of nucleotides (sic) to which an intercalating group is fixed via a covalent bond.

    专利号:EP-1542703-A2
    优先权日:2002-07-10
    标 题:Solid-phase and solution-phase synthesis of glycosylphosphatidylinositol glycans

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: T Maruyama, Et Al. Synthesis Of 8-(2"-Hydroxyethoxy)Adenosine-5',2"-Phosphate Derivative. Nucleic Acids Symp Ser. 1986:(17):61-3.
    [参考文献]: Thomas L Andresen, Et Al. Enzymatic Release Of Antitumor Ether Lipids By Specific Phospholipase A2 Activation Of Liposome-Forming Prodrugs. J Med Chem. 2004 Mar 25;47(7):1694-703.

    合成参考文献


    摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025).
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