CAS: 64248-63-1; 3,5-Difluorobenzonitrile

上下游产品

3,5-difluorobromobenzene copper(I) cyanide (3,5-difluorophenyl)diazirine sodium thiophenolate 3,5-difluorobenzylamine 3,5-difluorobenzamide 2-(3,5-difluorophenyl)benzo[d]thiazole 1-(3,5-difluorophenyl)-propan-1-one

1-溴-3,5-二氟苯置于异丙基氯化镁,Lithium Chloride,N,N-二甲基甲酰胺,氨,碘体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 4.25H,以82%的收率获得产物3,5-二氟苯甲腈
参考文献:实用的一锅法将芳基溴化物和β-溴苯乙烯转化为芳族腈和肉桂腈
标题:实用的一锅法将芳基溴化物和β-溴苯乙烯转化为芳族腈和肉桂腈
摘要:通过用mg车削和随后的dmf处理,然后用分子碘和nh 3水溶液处理,各种芳基溴化物以非常好的产率有效地转化为相应的芳族腈.相同的处理芳基溴化物,其是弱反应到mg屑,与我prmgcl.licl并随后dmf,接着用分子碘治疗和水溶液nh 3也得到相应的芳香腈以非常好的收率.另一方面,当使用n-甲酰基哌啶代替dmf时,对位取代的β-溴苯乙烯被转化为相应的对位取代的肉桂腈,即α,β-不饱和腈,通过相同的方法具有非常好至中等的收率.该反应通过简单的实验程序进行,不需要任何有毒的金属氰化物或昂贵的稀有金属.因此,本反应是实用的,对环境有益的一锅法,可通过形成格氏试剂及其dmf或dmf分别由芳基溴化物,β-溴苯乙烯和烷基溴化物制备芳族腈,肉桂腈和脂族腈.n-甲酰基哌啶加合物.
DOI:10.1016/j.Tet.2012.12.022

专利信息

专利号:US-2022081407-A1
优先权日:2020-09-11
标题 :Methods of preparing substituted indanes
发明人：STENGEL PETER J; XU RUI; SPENCER STACEY RENEE
权利人:PELOTON THERAPEUTICS INC
摘要:This application discloses methods for the synthesis of substituted indane analogs that modulate HIF-2α activity, as well as key intermediates produced thereby. The synthesis of 3-(((1S,2S,3R)-2,3-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile was exemplified.

专利号:US-5817827-A
优先权日:1995-11-21
标题:Method for the dehydration of amides to nitriles
发明人：BONRATH WERNER; PAULING HORST
权利人:HOFFMANN LA ROCHE
摘要:The present invention relates to a process for the dehydration of amides to nitrites which comprises carrying out the dehydration in the presence of an adduct of sulphur trioxide and an amine as the dehydrating reagent in a basic reaction mixture. Thereby, for example, aliphatic, aromatic and heteroaromatic amides are dehydrated to the corresponding nitrites, such as 5-carbamoyl-4-methyl-oxazole to 5-cyano-4-methyl-oxazole, a valuable intermediate in the synthesis of pyridoxine.

专利号:US-5254558-A
优先权日:1991-08-15
标 题:Substituted 1,3-diazines as leukocyte elastase inhibitors
发明人：BERNSTEIN PETER R; EDWARDS PHILIP D; THOMAS ROYSTON M; VEALE CHRIS A; WARNER PETER; WOLANIN DONALD J
权利人:ICI PLC
摘要:The present invention relates to certain novel substituted heterocycles which are 1-pyrimidinylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these substituted heterocycles, processes for preparing the substituted heterocycles, pharmaceutical compositions containing such substituted heterocycles and methods for their use.

专利号:BR-112016017679-B1
优先权日:2014-02-21
标题 :5-BENZYLISOQUINOLINE DERIVATIVE COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES, PROCESS FOR THE SYNTHESIS OF SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM

专利号:EP-1641453-B1
优先权日:2003-06-25
标题 :Product containing at least one phosphatase cdc25 inhibitor combined with at least one other anticancer agent
发明人：PREVOST GREGOIRE; BREZAK PANNETIER MARIE-CHRISTINE; DIOLEZ CHRISTIAN
权利人:IPSEN PHARMA
摘要:The invention relates to a product containing at least one phosphatase Cdc25 inhibitor combined with at least one other anticancer agent for simultaneous, separate or staggered therapeutic use during treatment for cancer. According to the invention, the other anticancer agent is preferably selected from: DNA base analogs such as 5-fluorouracil; inhibitors of type I and/or type II topoisomerases, such as camptothecin and the analogs thereof, doxorubicin or amsacrine; compounds interacting with the cellular spindle, for example, paclitaxel (Taxol); compounds acting on the cytoskeleton, such as vinblastine; inhibitors of the transduction of the signal passing via the heterotrimeric G proteins; prenyltransferase inhibitors, and especially farnesyltransferase inhibitors; cyclin-dependent kinase (CDKs) inhibitors; alkylating agents such as cisplatin; folic acid antagonists such as methotrexate; and inhibitors of DNA synthesis and cellular division, such as mitomycin C. The invention also relates to (1R)-1-[({(2R)-2-amino--3-[(8S)-8-(cyclohexylmethyl)-2-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]--3-oxopropyl}dithio)methyl]-2-[(8S)-8-(cyclohexylmethyl)-2-phenyl--5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]-2-oxoethylamine, or the pharmaceutically acceptable salts thereof, that can be used as anticancer agents.

专利号:US-2008176865-A1
优先权日:2005-06-15
标 题:Substituted arylpyrazoles
发明人：BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
权利人:PFIZER LTD
摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.