CAS: 64019-93-8; Dipivefrin Hydrochloride

该化合物是肾上腺素的一种药物,主要用于治疗青蒿素的眼科治疗方法,其主要优势在于其强化的亲脂性,它比肾上腺素更便于更好的玉米渗透,从而可以降低剂量和减少系统性副作用.一旦吸收,它就会被酯酶水解冻,通过增加水性幽默流出来减少体内压力.盐酸盐形式可以确保制剂的稳定性和溶性得到改善.其配方设计在保持治疗效率的同时,将局部刺激降到最低,使其在青蒿素治疗协议中成为首选选择.该化合物的特征是其可靠的药性基因特征和与眼科输血系统的兼容性.

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phenyl>ethan-1-ol(R)-2-(N-benzyl-N-methylamino)-1-3',4'-bis(pivaloyl)oxyphenylethan-1-ol pivaloyl chloride 4-formyl-1,2-phenylene bis(2,2-dimethylpropanoate) phenyl>-2-(p-tolylsulfinyl)ethan-1-on(R)-1-3',4'-bis(pivaloyl)oxyphenyl-2-(p-tolylsulfinyl)ethan-1-on

合成工艺路线路线简述

    📜[4-[2-[benzyl(Methyl)Amino]Propanoyl]-2-(2,2-Dimethylpropanoyloxy)Phenyl] 2,2-Dimethylpropanoate 反应生成 盐酸地匹福林
    参考文献:Ogata,Kadzumi;Tehrayama,Xideho
    标题:Ogata,Kadzumi;Tehrayama,Xideho

    海关参考信息

    专利信息


    专利号:US-6723850-B1
    优先权日:1998-08-03
    标 题 :Process for the synthesis of (1-H)-benzo[c]quinolizin-3-ones derivatives
    发明人:GUARNA ANTONIO; SERIO MARIO; OCCHIATO ERNESTO
    权利人:APPLIED RESEARCH SYSTEMS
    摘要:The present invention refers to a process for the preparation of (1H)-benzo[c]quinolizin-3-ones derivatives of general formula (I) which involves only three steps and the use, as starting products, of commercially available, or easily preparable, compounds. The compounds of formula (I) are useful as inhibitors of 5α-reductases.

    专利号:US-10384987-B2
    优先权日:2014-12-16
    标 题 :1,3-butadiene synthesis
    发明人:DREISBACH CLAUS; SCHLENK STEFAN; HOFFMANN MARTINA; LARCHER CHRISTOPH; FOELLINGER THOMAS
    权利人:ARLANXEO DEUTSCHLAND GMBH
    摘要:The invention relates to a process for preparing 1,3-butadiene by means of ene-yne metathesis over at least one transition metal catalyst of the element ruthenium.

    专利号:CN-109280055-A
    优先权日:2017-07-20
    标 题 :The method of asymmetric synthesis of ergot alkaloid

    专利号:CN-104812770-B
    优先权日:2012-07-31
    标题 :Synthesis of deuterated ribonucleosides, N-protected phosphoramidites and oligonucleotides

    专利号:CN-104812770-A
    优先权日:2012-07-31
    标 题 :Synthesis of deuterated ribonucleosides, N-protected phosphoramidites and oligonucleotides

    专利号:US-5512577-A
    优先权日:1994-06-02
    标 题:Bicyclic hexahydroaporphine and 1-benzyloctahydroisoquinoline therapeutic compositions and processes for utilizing said compositions
    发明人:ROCHE VICTORIA F; OHIA S EDET; ROCHE EDWARD B
    权利人:UNIV CREIGHTON
    摘要:The invention relates to the method of synthesis of bicyclic hexahydroaporphine compounds which may provide improved therapy for diseases characterized by an increase in intraocular pressure. More specifically, the present invention relates to the preparation of agents which may provide for improved treatment of patients with glaucoma or ocular hypertension. The present invention describes the intraocular pressure lowering capabilities of several of the bicyclic hexahydroaporphine structures.

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    主要参考文献


    1: Zhang L, Weizer JS, Musch DC. Perioperative medications for preventing temporarily increased intraocular pressure after laser trabeculoplasty. Cochrane Database Syst Rev. 2017 Feb 23;2:CD010746. doi: 10.1002/14651858.CD010746.pub2. Review.
    2: Sethi HS, Naik M, Gupta VS. Management of glaucoma in pregnancy: risks or choices, a dilemma? Int J Ophthalmol. 2016 Nov 18;9(11):1684-1690. eCollection 2016. Review.
    3: Nakamura-Shibasaki M, Latief MA, Ko JA, Funaishi K, Kiuchi Y. Effects of topical adrenergic agents on prostaglandin E2-induced aqueous flare and intraocular pressure elevation in pigmented rabbits. Jpn J Ophthalmol. 2016 Mar;60(2):95-102. doi: 10.1007/s10384-016-0428-2. Epub 2016 Feb 2. doi: 10.1038/npp.2015.248. Epub 2015 Aug 17.

    合成参考文献


    参考文献:10.1007/978-1-62703-263-6_23
    摘要:Borst C, Holzgrabe U. Cyclodextrin-mediated enantioseparation in microemulsion electrokinetic chromatography. Methods Mol Biol. 2013;970():363–75. doi: 10.1007/978-1-62703-263-6_23.
    参考文献:10.1007/s004170050206
    摘要:Edgar DF, Crabb DP, Rudnicka AR, Lawrenson JG, Guttridge NM, O'Brien CJ. Effects of dipivefrin and pilocarpine on pupil diameter, automated perimetry and LogMAR acuity. Graefe's Archive for Clinical and Experimental Ophthalmology. 1999 Jan 15;237(2):117–24. doi: 10.1007/s004170050206.
    摘要:Kiso to Rinsho. Clinical Report., 20(25), 1986
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