专利号:US-6723850-B1 优先权日:1998-08-03 标 题 :Process for the synthesis of (1-H)-benzo[c]quinolizin-3-ones derivatives 发明人:GUARNA ANTONIO; SERIO MARIO; OCCHIATO ERNESTO 权利人:APPLIED RESEARCH SYSTEMS 摘要:The present invention refers to a process for the preparation of (1H)-benzo[c]quinolizin-3-ones derivatives of general formula (I) which involves only three steps and the use, as starting products, of commercially available, or easily preparable, compounds. The compounds of formula (I) are useful as inhibitors of 5α-reductases.
专利号:US-10384987-B2 优先权日:2014-12-16 标 题 :1,3-butadiene synthesis 发明人:DREISBACH CLAUS; SCHLENK STEFAN; HOFFMANN MARTINA; LARCHER CHRISTOPH; FOELLINGER THOMAS 权利人:ARLANXEO DEUTSCHLAND GMBH 摘要:The invention relates to a process for preparing 1,3-butadiene by means of ene-yne metathesis over at least one transition metal catalyst of the element ruthenium.
专利号:CN-109280055-A 优先权日:2017-07-20 标 题 :The method of asymmetric synthesis of ergot alkaloid
专利号:CN-104812770-B 优先权日:2012-07-31 标题 :Synthesis of deuterated ribonucleosides, N-protected phosphoramidites and oligonucleotides
专利号:CN-104812770-A 优先权日:2012-07-31 标 题 :Synthesis of deuterated ribonucleosides, N-protected phosphoramidites and oligonucleotides
专利号:US-5512577-A 优先权日:1994-06-02 标 题:Bicyclic hexahydroaporphine and 1-benzyloctahydroisoquinoline therapeutic compositions and processes for utilizing said compositions 发明人:ROCHE VICTORIA F; OHIA S EDET; ROCHE EDWARD B 权利人:UNIV CREIGHTON 摘要:The invention relates to the method of synthesis of bicyclic hexahydroaporphine compounds which may provide improved therapy for diseases characterized by an increase in intraocular pressure. More specifically, the present invention relates to the preparation of agents which may provide for improved treatment of patients with glaucoma or ocular hypertension. The present invention describes the intraocular pressure lowering capabilities of several of the bicyclic hexahydroaporphine structures.
1: Zhang L, Weizer JS, Musch DC. Perioperative medications for preventing temporarily increased intraocular pressure after laser trabeculoplasty. Cochrane Database Syst Rev. 2017 Feb 23;2:CD010746. doi: 10.1002/14651858.CD010746.pub2. Review. 2: Sethi HS, Naik M, Gupta VS. Management of glaucoma in pregnancy: risks or choices, a dilemma? Int J Ophthalmol. 2016 Nov 18;9(11):1684-1690. eCollection 2016. Review. 3: Nakamura-Shibasaki M, Latief MA, Ko JA, Funaishi K, Kiuchi Y. Effects of topical adrenergic agents on prostaglandin E2-induced aqueous flare and intraocular pressure elevation in pigmented rabbits. Jpn J Ophthalmol. 2016 Mar;60(2):95-102. doi: 10.1007/s10384-016-0428-2. Epub 2016 Feb 2. doi: 10.1038/npp.2015.248. Epub 2015 Aug 17.
合成参考文献
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