合成目标产物 4-Pyridyl Acetone 主要起始原料 4-Methylpyridine And Acetyl Chloride
(文献来源)合成步骤主要原料 4-Methylpyridine 和 Acetyl Chloride
[1-(2,6-Dichloro-Benzyl)-1H-[4]Pyridyliden]-Acetone置于水,氢溴酸体系中,化学反应生成 1-(4-吡啶基)丙酮 参考文献:Kroehnke Et Al.,Justus Liebigs Annalen Der Chemie,1956,Vol. 600,P. 176,188 标题:Kroehnke Et Al.,Justus Liebigs Annalen Der Chemie,1956,Vol. 600,P. 176,188
专利号:US-2008194629-A1 优先权日:2005-05-03 标题 :3-Mono-and 3,5-Disubstituted Piperidine Derivatives as Renin Inhibitors 发明人:BAESCHLIN DANIEL KASPAR; BREITENSTEIN WERNER; EHRHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; RUDISSER SIMON; VANGREVELINGHE ERIC; IRIE OSAMU; UMEMURA ICHIRO; SUZUKI MASAKI; MOGI MUNETO; KANAZAWA TAKANORI; YOKOKAWA FUMIAKI; NIHONYANAGI ATSUKO 权利人:BAESCHLIN DANIEL KASPAR; BREITENSTEIN WERNER; EHRHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; RUDISSER SIMON; VANGREVELINGHE ERIC; IRIE OSAMU; UMEMURA ICHIRO; SUZUKI MASAKI; MOGI MUNETO; KANAZAWA TAKANORI; YOKOKAWA FUMIAKI; NIHONYANAGI ATSUKO 摘要:The invention relates to 3,5-piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-piperidine compound, and/or a method of treatment comprising administering a 3,5-piperidine compound, a method for the manufacture of a 3,5-piperidine compound, and novel intermediates and partial steps for their synthesis. Especially, the 3,5-piperidine compounds have the formula I, wherein the symbols have the meanings described in the specification.
专利号:US-RE50050-E 优先权日:2013-06-21 标 题 :Pyrimidinedione compounds 发明人:OSLOB JOHAN; ANDERSON ROBERT; AUBELE DANIELLE; EVANCHIK MARC; FOX JONATHAN CHARLES; KANE BRIAN; LU PUPING; MCDOWELL ROBERT; RODRIGUEZ HECTOR; SONG YONGHONG; SRAN ARVINDER 权利人:MYOKARDIA INC 摘要:Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.
专利号:US-8178531-B2 优先权日:2010-02-23 标 题:Antiviral agents 发明人:OR YAT SUN; WANG GUOQIANG; GAO XURI 权利人:OR YAT SUN; WANG GUOQIANG; GAO XURI; ENANTA PHARM INC 摘要:The present invention relates to antiviral compounds of formula (I), n ncompositions containing these compounds, processes for their preparation, intermediates in their synthesis, and their use as therapeutics for prevention of organ transplantation rejection, the treatment of immune disorders and inflammation, and treatment of viral (particularly hepatitis C viral) infection.
参考标题:Chemoenzymatic Asymmetric Synthesis Of Pyridine‐based α‐fluorinated Secondary Alcohols 作者:Timo Broese,Peter Ehlers,Peter Langer,Jan Langermann |发布日期:2021.12.2 摘要:Two For One: A Straightforward Chemoenzymatic Synthesis Pathway Towards Valuable Chiral Alcohols With α-Fluorination In Close Proximity To The Chiral Center And A Pyridine Ring Is Presented. High Conversions With Excellent Enantioselectivities Were Found, Showing Its High Synthetic Potential.