CAS: 6090-95-5; Rel-(1R,2R,3S,4S,5R,6S)-7-Oxabicyclo[4.1.0]Heptane-2,3,4,5-Tetraol

该化合物是一个以其作为生化中间体的作用而著称的双环有机化合物,其特征是其四氧化物功能组,有助于其反应和有机合成的潜在应用;该化合物一般没有颜色,可视其纯度和形态而成为黄色液体或固体;B 氧化铜,因其能够抑制某些酶,特别是甘油,使其对生化研究和潜在的治疗应用感兴趣而引人注目;其结构包括一个双环框架,可增强其稳定性和再活性;此外,它可溶于有机溶剂,便于其在各种化学反应中使用;在处理该化合物时,应注意安全防范,因为如果浸入或吸入,可能会对健康造成危害;总的来说,Cduritol B 过氧化物是合成有机化学和生物研究的宝贵工具.

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6705-49-3 106-86-5 133319-97-8

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上下游产品

CAS号110550-28-2 (+)-(1S,2R,3S,4... | CAS号138258-55-6 (+/-) conduritol B | CAS号4381-96-8 (+/-)-(1,3/2,4)... | CAS号40617-60-5 1,2:5,6-双-O-(1-... | CAS号120710-66-9 (±)-1,6-di-O-be... | CAS号120679-73-4 (+/-)-3,4-di-O-... | CAS号85798-11-4 (4S,5R,6S)-4,5,... | CAS号102997-58-0 conduritol B

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    专利信息


    专利号:WO-2023008461-A1
    优先权日:2021-07-27
    标题:Medicament for treatment and/or prevention of cancer
    发明人:KUME MASAHIKO; OKANO FUMIYOSHI; SAITO TAKANORI
    权利人:TORAY INDUSTRIES
    摘要:The present invention relates to a medicament for the treatment and/or prevention of cancer, the medicament being characterized by comprising an antibody having an immunological reactivity with CAPRIN-1 protein or a fragment of the antibody and a drug capable of inhibiting the N-glycoside-linked sugar chain synthesis of a glycoprotein which are combined with each other in a blended or separated form.

    专利号:US-2010151526-A1
    优先权日:2005-09-22
    标 题 :Method of Producing Sucrose-6-Acetate by Whole-Cell Biocatalysis
    发明人:RATNAM RAKESH; AURORA SUNDEEP; SUBRAMANIYAM P
    权利人:PHARMED MEDICARE PVT LTD
    摘要:A process is described which uses whole cell preparations, immobilized or without immobilization, of a microorganism, including Aureobasidium pullulans , capable of forming enzymes of the group of fructosyltransferases, for catalyzing a reaction between sucrose and 6-O-protected glucose for formation of 6-O-protected sucrose, an intermediate in synthesis of trichlorogalactosucrose. 6-O-protected Sucrose is separated from high molecular weight by-products of the reaction having molecular weight of 500 daltons and more by reverse osmosis, and further purified by column chromatography.

    专利号:US-7429460-B2
    优先权日:2003-01-15
    标 题 :Methods of screening for inhibitors of phospholipid synthesis related to glycolipid-storage diseases
    发明人:FUTERMAN ANTHONY H; BODENNEC JACQUES; PELLED DORI
    权利人:YEDA RES & DEV
    摘要:The present invention discloses methods of screening for identification of compounds that inhibit novel targets in the enzymatic pathway of phospholipid synthesis that are related to glycolipid storage diseases, and use of the compounds for treating patients affected with glycolipid storage diseases, particularly Gaucher disease. Specifically, the compounds of the present invention are intended to inhibit the accumulation of phosphatidylcholine (PC), wherein PC accumulation is increased due to the activation of CTP:phosphocholine cytidylyltransferase (CCT) upon glucosylceramide (GlcCer) accumulation.

    专利号:CN-118165950-A
    优先权日:2024-03-18
    标 题:Application of laminaria oligosaccharide phosphorylase in synthesis of laminaria oligosaccharide and multienzyme catalytic system

    专利号:US-6562606-B1
    优先权日:1993-03-19
    标 题:Methods and compositions for disrupting the epithelial barrier function
    发明人:ELIAS PETER M; FEINGOLD KENNETH R; HOLLERAN WALTER M
    权利人:UNIV CALIFORNIA; CELLEGY PHARMA INC
    摘要:A method for disrupting epithelial barrier function in a host in need of the topical administration of a physiologically active substance which comprises applying to the epithelium of the host, barrier-disrupting amount of at least one agent selected from the group consisting of an inhibitor of ceramide synthesis, inhibitor of acylceramide synthesis, inhibitor of glucosylceramide synthesis, and inhibitor of sphingomyelin synthesis, an inhibitor of fatty acid synthesis, an inhibitor of cholesterol synthesis, a degradation enzyme of ceramides, acylceramide, glucosylceramides, sphingomyelin, an inhibitor of phospholipid, glycosphingolipid, including glucosylceramide, acylceramide or sphingomyelin degradation, and both inhibitors and stimulators of metabolic enzymes of free fatty acids, ceramide, and cholesterol, as well as a topical composition useful therefor are disclosed.

    专利号:US-2004137531-A1
    优先权日:2003-01-15
    标题 :Methods of screening for inhibitors of phospholipid synthesis related to glycolipid-storage diseases

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Lee KJ, Boyd SA, Radin NS. Improved synthesis of conduritol B epoxide. Carbohydr Res. 1985 Nov 15;144(1):148-54. doi: 10.1016/0008-6215(85)85015-1. 286(3):584-600. doi: 10.1111/febs.14744. Epub 2019 Feb 2.
    3: Newburg DS, Shea TB, Yatziv S, Raghavan SS, McCluer RH. Macrophages exposed in vitro to conduritol B epoxide resemble Gaucher cells. Exp Mol Pathol. 1988 Jun;48(3):317-23. doi: 10.1016/0014-4800(88)90068-8. 101(5):255-9. 672(1):29-32. doi: 10.1016/0304-4165(81)90276-2. 483(1):135-40. doi: 10.1016/0005-2744(77)90015-8. 828(3):236-40. 37(3):499-510.
    9: Jo J, Yang L, Tran HD, Yu W, Sun AX, Chang YY, Jung BC, Lee SJ, Saw TY, Xiao B, Khoo ATT, Yaw LP, Xie JJ, Lokman H, Ong WY, Lim GGY, Lim KL, Tan EK, Ng HH, Je HS. Lewy Body-like Inclusions in Human Midbrain Organoids Carrying Glucocerebrosidase and α-Synuclein Mutations. Ann Neurol. 2021 Sep;90(3):490-505. doi: 10.1002/ana.26166. Epub 2021 Aug 10.

    合成参考文献

    合成方法参考DOI号:10.1016/S0008-6215(00)00192-0
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