CAS: 59785-68-1; Ac-D-Pro-Oh

相似化合物

68-95-1 1074-79-9 123958-87-2

上下游产品

N-acetyl-L-proline benzyl ester L-proline N-(N'-acetyl-L-prolyl)glycine benzyl ester N-(N'-acetyl-L-prolyl)-L-alanine benzyl ester N-(N'-acetyl-L-prolyl)-N-nitrosoglycine N-(N'-acetyl-L-prolyl)-L-phenylalanine

乙酸酐,D-脯氨酸 以 乙酸乙酯 作为反应溶剂,化学反应 0.17H,反应生成 N-乙酰-D-脯氨酸
参考文献:基于手性salen-Uo 2大环化合物的中性对位受体识别非手性和手性铵盐
标题:基于手性salen-Uo 2大环化合物的中性对位受体识别非手性和手性铵盐
摘要:单核(m20)和双核(m40)铀酰手性大环配合物,包含含有两个与手性二亚胺桥连接的苯环的salen单元和(R)-Binol单元可作为非手性和手性季铵盐的有效位位受体.已测量氯仿溶液中许多季盐的1:1配合物的结合亲和力,包括四甲基铵(tma),四乙基铵(tea),四丁基铵(tba)和乙酰胆碱(ach)以及三甲基苯胺(triman),苄基三甲基铵(bntrima),(α-甲基苄基)三甲基铵和吡咯烷鎓阳离子.所述盐的阴离子是由硬路易斯酸性铀酰位点结合,随着增加的结合效率上增加了阴离子硬度(i-<溴-<氯-),而联萘基部分或水杨醛单元或二亚胺桥的苯环的ch-π或π-π引力可确保识别阳离子配偶体.通过mm计算获得的受体-阴离子-阳离子三元配合物的优化结构得到2D-Roesy NMR测量的支持.
DOI:10.1021/jo902328Y

专利信息

专利号:US-5219741-A
优先权日:1989-09-06
标题:Method of making L-proline using an N-acyl-L-protine acylase
发明人：GROEGER ULRICH; LEUCHTENBERGER WOLFGANG; DRAUZ KARLHEINZ
权利人:DEGUSSA
摘要:A microbiologically produced, thermostable N-acylproline-acylase and a process for obtaining it from Comamonas testosteroni DSM 5416 and Alcaligenes denitrificans DSM 5417. The enzyme is useful for the synthesis of L-proline from various N-acyl-L-proline derivatives.

专利号:US-5166426-A
优先权日:1991-04-12
标 题 :Process for producing l-carnitine from d,l-carnitine nitrile salts
发明人：JAKOB HARALD; HUTHMACHER KLAUS; KLENK HERBERT
权利人:DEGUSSA
摘要:Synthesis of L-carnitine by chemical optical resolution of D,L-carnitine nitrile salts, where the D,L-carnitine nitrile salt is reacted with optically active N-acetylproline as the resolving agent in order to form the diastereomer salts after conversion to the hydroxide form, one of the two diastereomer salts is separated by fractional crystallization and the fraction containing mainly L-carnitine nitrile salt is treated with an optically inactive strong acid in order to split off the optically active N-acetylproline and then the resolving agent is separated and the resulting L-carnitine nitrile salt is saponified to L-carnitine. N-acetyl-L-proline is used as the resolving agent and the diastereomer (LL) salt is obtained in crystalline form in a high optical purity by fractional crystallization and the L-carnitine nitrile salt obtained after splitting off and separating N-acetyl-L-proline is used directly for saponification without further crystallization.

专利号:US-5120652-A
优先权日:1989-09-06
标 题 :Substantially purified n-acyl-l-proline acylase from comamonas testosteroni dsm 5416 and alcaligenes denitrificans dsm 5417
发明人：GROEGER ULRICH; LEUCHTENBERGER WOLFGANG; DRAUZ KARLHEINZ
权利人:DEGUSSA
摘要:A substantially purified N-acyl-L-proline-acylase from Comamonas testosteroni DSM 5416 and Alcaligenes denitrificans DSM 5417. The enzyme is useful for the synthesis of L-proline from various N-acyl-L-proline derivatives.