CAS: 57757-57-0; Di(N-Succinimidyl) 3,3-Dithiodipropionate [cross-Linking Reagent]

相似化合物

117235-10-6 23024-29-5 68528-80-3

上下游产品

CAS号6066-82-6 N-羟基琥珀酰亚胺 | CAS号1119-62-6 3,3'-二硫代二丙酸 | CAS号74124-79-1 N,N'-二琥珀酰亚胺基碳酸酯

N-羟基丁二酰亚胺,3,3'-二氢氧啉酸置于n,N'-二环己基碳二亚胺体系中,化学反应 48.0H,以32%的收率获得产物3,3'-二硫代二丙酸 二(N-羟基丁二酰亚胺酯)
参考文献:用于靶向药物递送的刺激响应性聚合物纳米胶囊的简便,无模板合成
标题:用于靶向药物递送的刺激响应性聚合物纳米胶囊的简便,无模板合成
摘要:芝麻开门!已经开发出一种合成刺激响应性聚合物纳米胶囊的方法.还原不稳定的聚合物纳米胶囊不仅可以进行简单的非共价表面改性,还可以在细胞内环境中响应预定义的氧化还原刺激释放封装的货物.
DOI:10.1002/anie.201000818

专利信息

专利号:US-11851651-B2
优先权日:2017-06-19
标 题 :Automated methods for scalable, parallelized enzymatic biopolymer synthesis and modification using microfluidic devices
发明人：BANAL JAMES; BERLEANT JOSEPH DON; SHEPHERD TYSON; BATHE MARK
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Methods for the automated template-free synthesis of user-defined sequence controlled biopolymers using microfluidic devices are described. The methods facilitate simultaneous synthesis of up to thousands of uniquely addressed biopolymers from the controlled movement and combination of regents as fluid droplets using microfluidic and EWOD-based systems. In some forms, biopolymers including nucleic acids, peptides, carbohydrates, and lipids are synthesized from step-wise assembly of building blocks based on a user-defined sequence of droplet movements. In some forms, the methods synthesize uniquely addressed nucleic acids of up to 1,000 nucleotides in length. Methods for adding, removing and changing barcodes on biopolymers are also provided. Biopolymers synthesized according to the methods, and libraries and databases thereof are also described. Modified biopolymers, including chemically modified nucleotides and biopolymers conjugated to other molecules are described.

专利号:US-10254287-B2
优先权日:2015-07-21
标题 :Protein fluorescent nanoparticles and methods of synthesis thereof
发明人：KUMAR CHALLA VIJAYA; STROMER BOBBI SHANYELLE
权利人:UNIV CONNECTICUT
摘要:Disclosed herein are stable and versatile protein nanoparticles having a range of tunable fluorescent properties. Such nanoparticles may find utility in biological imaging. Methods of synthesis of such nanoparticles are also disclosed.

专利号:US-2006040283-A1
优先权日:2001-04-11
标题:Methods of manipulating nucleic acids
发明人：XIANG CHARLIE; BROWNSTEIN MICHAEL J
权利人:US GOV HEALTH & HUMAN SERV
摘要:Methods are provided for labeling nucleic acid molecules for use in hybridization reactions, and kits employing these methods. The level of labeling is increased by including one or more reactive modifications, such as amine-modifications, into the primers used to initiate synthesis of the nucleic acid molecule, for instance through random-primed reverse transcription. Also provided are modified random primers (such as amine-modified random primers) useful in these methods, labeling and hybridization kits comprising such primers, labeled nucleic acid molecules and mixtures of molecules, and methods for using them. Methods are also provided for amplifying a nucleic acid template contained within extremely small samples, in some cases as little as one cell. In particular embodiments, a single random primer is used for all steps of the amplification method. The nucleic acid template can either be of cellular or viral origin. The disclosure also provides an improved method of fixing cells, tissue sections, or laser microdissected sections from which RNA can be obtained for subsequent use as RNA templates or for generating labeled probe.

专利号:US-12195777-B2
优先权日:2018-02-02
标 题 :Polynucleotide synthesis method, kit and system
发明人：HERON ANDREW JOHN
权利人:OXFORD NANEPORE TECH PLC; OXFORD NANOPORE TECH PLC
摘要:The invention relates to new in vitro methods for synthesising a polymer, particularly a polynucleotide molecule, having a pre-defined sequence of units such as nucleotides. For synthesising a polynucleotide molecule the methods involve a process of extending a polynucleotide synthesis molecule with a transfer nucleotide. The methods additionally involve repeating the extension process multiple times to iteratively extend the polynucleotide molecule with multiple transfer nucleotides to generate a new polynucleotide molecule having a pre-defined nucleotide sequence. The invention also relates to in vitro methods of joining multiple synthetic polynucleotides following synthesis to form larger synthetic polynucleotides, as well as devices and systems for performing the extension, synthesis and assembly methods of the invention.

专利号:US-2008051323-A1
优先权日:2004-08-21
标 题 :Chloroquine drug compositions and methods for their synthesis
发明人：KOSAK KENNETH M
权利人:KOSAK KENNETH M
摘要:This invention discloses compositions of chloroquine-coupled active agents, including methods for their preparation. The prior art has shown that chloroquines given as free drug in high enough concentration, enhances the release of various agents from cellular endosomes into the cytoplasm. The purpose of these compositions is to provide a controlled amount of chloroquine at the same site where the active agent is delivered, thereby reducing the overall dosage needed. n The compositions comprise a chloroquine substance coupled to an active agent directly or through a variety of pharmaceutical carrier substances. The carrier substances include polysaccharides, synthetic polymers, proteins, micelles and other substances for carrying and releasing the chloroquine compositions in the body for therapeutic effect. The compositions can also include a biocleavable linkage for carrying and releasing active agents for therapeutic or other medical uses. The invention also discloses carrier compositions that are coupled to targeting molecules for targeting the delivery of chloroquine substances and active agents to their site of action.

专利号:US-5668106-A
优先权日:1987-05-20
标 题 :Method and compositions for making ACSF and ACSF antagonists
发明人：WOOD WILLIAM I; MARTIN THOMAS JOHN
权利人:UNIV MELBOURNE; GENENTECH INC
摘要:The complete amino acid and nucleotide sequence for adenylate cyclase stimulating factor is provided, thereby facilitating the synthesis of ACSF in recombinant cell culture. ACSF amino acid sequence variants and ACSF antibodies are provided which are useful in the treatment of humoral hypercalcemia of malignancy or in immunoassays for ACSF. In particular, antibodies capable of binding only the C-terminal domains of ACSF are useful in immunoassays for ACSF which avoid interference by parathyroid hormone. Also provided are novel polypeptides selected from the group of the ACSF basic peptide, the ACSF C-terminal peptide, or the ACSF domain containing both of the basic and C-terminal peptides.