CAS: 56354-06-4; 11-Nor-9-Carboxy-δ9-Tetrahydrocannabinol

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dronabinol 9-tetrahydr°Cannabinol tert-butyldimethylsilyl ether(-)-11-nor-9-carboxy-9-tetrahydr°Cannabinol tert-butyldimethylsilyl ether carbon dioxide 9-Tetrahydr°Cannabinol-11-oic acid glucuronide9-Tetrahydr°Cannabinol-11-oic acid glucuronide

合成工艺路线路线简述

    📜Dl-6Aα,7,10,10Aα-Tetrahydro-1-Hydroxy-6,6-Dimethyl-3-Pentyl-6H-Dibenzo[b,D]Pyran-9(8H)-On置于正丁基锂,高氯酸,四甲基乙二胺,对甲苯磺酸体系中,用 四氢呋喃,乙醇,正己烷,甲苯 作为反应溶剂,化学反应 29.03H,反应生成 (-)-11-N-9-羧基-δ9-Thc
    参考文献:Preparation Of Racemic,(−)-And (+)-11-Nor-δ9-Tetrahydrocannabinol-9-Carboxylic Acid
    标题:Preparation Of Racemic,(−)-And (+)-11-Nor-δ9-Tetrahydrocannabinol-9-Carboxylic Acid
    摘要:
    DOI:10.1021/jo970969E

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    主要参考文献

    参考标题:Studies On The Synthesis Of (-)-11-Nor-9-Carboxy-δ9-Tetrahydrocannabinol (Thc) And Related Compounds: An Improved Oxidative Procedure
    作者:Craig Siegel,Patrick M. Gordon,Raj K. Razdan
    摘要:A Facile Procedure Is Described Whereby î”9-Thc Aldehydes 4, As Their Tert-Butyldimethylsilyl Derivatives, Are Conveniently Oxidized To The Corresponding Acids With Sodium Chlorite In The Presence Of A Large Excess Of 2-Methyl-2-Butene Without Isomerization Of The î”9-Double Bond. Deprotection Of The O-Protecting Group With Tetrabutylammonium Fluoride In Tetrahydrofuran Gave The Acids 2 In An Overall Yield Of >= 80%. A Study Of Other Oxidizing Agents And Protecting Groups Demonstrated That This Is The Procedure Of Choice For The Preparation Of 9-Carboxy-î”9-Tetrahydrocannabinols.

    合成参考文献

    参考DOI号:10.1021/jo970969e
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