专利号:US-7855287-B2 优先权日:2007-01-24 标题 :Preparation of high purity phenothiazine N-alkylsulfonates and their use in chemiluminescent assays for the measurement of peroxidase activity 发明人:DELLA CIANA LEOPOLDO 权利人:CYANAGEN SRL 摘要:A process is described for preparing, efficiently and with a high degree of purity N-alkylsulfonates of phenothiazine. The process consists in (a) the preparation of the phenothiazine anion, and (b) the reaction of said anion with cyclic alkyl sulfonates, such as 1,3-propane sultone and 1,4-butane sultone. This process is simpler, more direct, and more efficient than the procedures currently used for the synthesis of N-alkylsulfonates derivatives of phenothiazine. In addition, the products obtained with this process are far more pure than those obtained through current procedures and therefore ideal for bioanalytical applications that require high sensitivity, such as assays based on the measurement of peroxidase activity using chemiluminescence.
专利号:EP-3757084-A1 优先权日:2019-06-27 标 题:Mechanochemical synthesis method using a catalytically active moulded body 发明人:BORCHARDT LARS; GRÄTZ SVEN; VOGT CHRISTIAN 权利人:UNIV RUHR BOCHUM 摘要:The present invention relates to a mechanochemical method for the direct heterogeneous catalysis of a chemical reaction, comprising the following steps, (a) providing at least one starting material; (b) providing a shaped body, the shaped body comprising at least one catalytically active material; and (c) direct mechanochemical conversion of the at least one starting material into a product by bringing it into contact with the shaped body in an energy-transferring manner; wherein the solids content in the heterogeneously catalyzed chemical reaction is more than 30 wt .-%, and wherein the catalytically active material has a compression modulus of at least 160 GPa and a Mohs hardness of at least 3.0., and the use of a catalytically active shaped body in this chemical reaction.
专利号:CN-119735535-A 优先权日:2024-11-26 标 题:Synthesis method and application of electrophilic selenium deuterated methyl reagent
专利号:CN-113979939-A 优先权日:2021-09-12 标题 :Synthesis method and application of 2-arylquinoline-4-carboxylic ester
[参考文献]: B M Kinsey, Et Al. Synthesis And Biological Activity Of 125I/127I-Phenylboronic Acid Derivatives. Nucl Med Biol. 1993 Jan;20(1):13-22. [参考文献]: Claude Haan, Et Al. A Cost Effective Non-Commercial Ecl-Solution For Western Blot Detections Yielding Strong Signals And Low Background. J Immunol Methods. 2007 Jan 10;318(1-2):11-9. [参考文献]: Ida Dreier, Et Al. A Click Chemistry Approach To Pleuromutilin Derivatives, Part 2: Conjugates With Acyclic Nucleosides And Their Ribosomal Binding And Antibacterial Activity. J Med Chem. 2012 Mar 8;55(5):2067-77. [参考文献]: Kazuhiko Tsukagoshi, Et Al. Enhancing Effect Of Phenylboronic Acid Compounds And Their Interactions With The Diol Groups Of Saccharides In A Capillary Electrophoresis-Chemiluminescence Detection System. Anal Sci. 2007 Feb;23(2):227-30. [参考文献]: Kazuhiko Tsukagoshi, Et Al. Molecular Recognition Of Mono- And Disaccharides Through Interaction With P-Iodophenylboronic Acid In Capillary Electrophoresis With A Chemiluminescence Detection System. J Chromatogr A. 2006 Aug 4;1123(1):106-12.
合成参考文献
摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2018) 3, 42. 摘要:Podlech, J., Science of Synthesis Knowledge Updates, (2019) 1, 393. 摘要:Rudzinski, D. M.; Leadbeater, N. E., Science of Synthesis Knowledge Updates, (2012) 1, 371. 摘要:González-Bello, C., Science of Synthesis Knowledge Updates, (2018) 1, 220. 摘要:Werner, E. W.; Sigman, M. S., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 82.