CAS: 484-74-2; Isodictamnine

该化合物是鲁塔塞亚家族植物(如Diktanus物种)中自然产生的一种松软藻类,它显示出显著的生物活动,包括潜在的抗微生物,抗炎和细胞毒性,使它成为药物研究兴趣的复合体,其分子结构以松松和肾环系统为特征,有助于它与生物目标的互动.Isodictamine还因其在植物防御机制中的作用而受到研究.作为参考标准,它被用于分析化学,用于植物提取物的鉴定和定量.其稳定性和定义明确的特性支持其在科学研究中的效用.

结构式图片

相似化合物

719-54-0 83-54-5 10328-92-4

物理性质

MSDS等安全信息

上下游产品

diazomethane furo[2,3-b]quinolin-4(9H)-one dimethyl sulfate dictamnine

合成工艺路线路线简述

    📜4-羟基-N-甲基-2-喹啉置于rhodium(II) Pivalate,四丁基氟化铵,三乙胺,甲烷磺酰基叠氮化物体系中,用 四氢呋喃,氟苯,乙醇 作为反应溶剂,化学反应 12.17H,反应生成 9-甲基呋喃并[2,3-B]喹啉-4(9H)-酮
    参考文献:Rhodium-Mediated Dipolar Cycloaddition Of Diazoquinolinediones
    标题:Rhodium-Mediated Dipolar Cycloaddition Of Diazoquinolinediones
    摘要:As An Entry To Furoquinoline Structures Of Natural Origin,The Rhodium-Mediated Dipolar Cycloaddition Of Diazoquinolinediones With Alkenes And Alkynes Has Been Examined. Because Of The Unsymmetrical Nature Of The Diazo Compounds,Both Linear And Angular Furoquinoline Products Are Possible. For The Most Part,A Mixture Of Regioisomers Is Generated In Moderate To Good Yields,Though In A Few Cases Dominant Products Are Obtained In High Yields. The Products Can Be Further Converted To Naturally occurring Alkaloids Such As Isodictamnine. A Novel Observation In This Work Is That Catalytic Quantities Of Acid Enhance The Yield And Regiochemical Control In The Cycloaddition.
    DOI:10.1021/jo982503H

    海关参考信息

    专利信息


    专利号:US-2895956-A
    优先权日:1957-09-09
    标 题 :Synthesis of furoquinoline derivatives
    发明人：HANS TUPPY
    权利人:HANS TUPPY

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    主要参考文献

    [参考文献]: Towers Gh, Et Al. Phototoxic Furanoquinolines Of The Rutaceae. Planta Med. 1981 Feb;41(2):136-42.

    合成参考文献


    参考文献:10.1055/s-0028-1084384|10.1055/s-0028-1084393|10.1055/s-0028-1084394|10.1055/s-0028-1084396|10.1055/s-0028-1084416|10.1055/s-0028-1084418
    摘要:Chou T, Chen I, Hwang T, Liao S, Lin Y, Lin Y, Chen J. New isobenzofurans and anti-inflammatory constituents from the root of Pittosporum illicioides var. illicioides. Planta Med. 2008 Jul;74(09). doi: 10.1055/s-0028-1084384.
    参考文献:10.1016/s0031-9422(98)00519-6
    摘要:Wu T, Li C, Leu Y, Hu C. Limonoids and alkaloids of the root bark of Dictamnus angustifolius. Phytochemistry. 1999 Feb;50(3):509–12. doi: 10.1016/s0031-9422(98)00519-6.
    参考文献:10.1016/0031-9422(94)00567-d
    摘要:Ahsan M. Terpenoids, alkaloids and coumarins from Boronia inornata and Boronia gracilipes. Phytochemistry. 1995 Mar;38(5):1275–8. doi: 10.1016/0031-9422(94)00567-d.
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