CAS: 4387-36-4; 2-Iodobenzonitrile

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CAS号100-47-0 苯甲腈 | CAS号1829-28-3 2-碘苯甲酸乙酯 | CAS号1885-29-6 2-氨基苯甲腈 | CAS号3930-83-4 2-碘苯甲酰胺 | CAS号2042-37-7 邻溴苯腈 | CAS号88-67-5 邻碘苯甲酸 | CAS号615-37-2 2-碘甲苯 | CAS号825-50-3 2-Cyan-1-jod-be... | CAS号615-43-0 2-碘苯胺 | CAS号10512-65-9 1,3-benzothiazi... | CAS号3930-83-4 2-碘苯甲酰胺 | CAS号40888-26-4 2-乙炔基苯甲腈 | CAS号491-30-5 异喹诺酮 | CAS号147531-47-3 2-(ISOPROPYLAMI... | CAS号148651-34-7 benzonitrile,io... | CAS号149989-78-6 2-((4,4,5,5-四甲基... | CAS号39959-51-8 2-碘苄胺 | CAS号91054-33-0 2-乙酰苯甲腈 | CAS号1801-42-9 2.3-二苯基-1-二氢茚酮

2-氨基苯甲腈置于盐酸,1-Methyl-3-(2-[2-(1-Methyl-1H-Imidazol-3-Ium-3-yl)Ethyloxy]Ethyl)-1H-Imidazol-3-Ium Dinitrite,Potassium Iodide体系中,用 水 作为反应溶剂,化学反应 0.59H,以88%的收率获得产物2-碘氰基苯
参考文献:亚硝酸盐离子液体作为原位合成芳基碘化物和叠氮化物的新试剂
标题:亚硝酸盐离子液体作为原位合成芳基碘化物和叠氮化物的新试剂
摘要:一种新的离子液体1-亚甲基-3-(2-[2-(1-甲基-1 H-咪唑-3-基-3-基)乙氧基]乙基)-1 H-咪唑-3-亚硝酸盐,是合成的.该离子液体在芳基胺重氮化成其相应的重氮盐时用作方便的硝鎓源,将其分别用碘化钾或叠氮化钠转化为芳基碘化物和芳基叠氮化物.具有吸电子基团或供电子基团的各种芳基胺以优异的产率被转化为相应的芳基碘化物和芳基叠氮化物.该方法的优点是使用温和的反应条件,缩短反应时间并避免使用有毒溶剂.
DOI:10.1007/s11164-013-1505-5

专利信息

专利号:US-8906915-B2
优先权日:2009-12-17
标 题:Compounds, compositions, and methods for controlling biofilms
发明人：DE KEERSMAECKER SIGRID; DE VOS DIRK; ERMOLATEV DENIS; STEENACKERS HANS; VAN DER EYCKEN ERIK; VANDERLEYDEN JOZEF; SAVALIYA BHARAT S
权利人:DE KEERSMAECKER SIGRID; DE VOS DIRK; ERMOLATEV DENIS; STEENACKERS HANS; VAN DER EYCKEN ERIK; VANDERLEYDEN JOZEF; SAVALIYA BHARAT S; UNIV LEUVEN KATH
摘要:The invention relates to substituted 2-aminoimidazoles and their imidazo[1,2-a]pyrimidinium salts precursors being active against biofilm formation. The invention also relates to imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent, and to substituted 2-aminoimidazoles wherein the amino group bears a terminal heterocyclic group such as a triazolyl group which are formed through azide-alkyne Huisgen cycloaddition starting from said imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent. The invention also relates to a class of N-(azidoalkyl)pyrimidin-2-amines useful as starting materials for the synthesis of said imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent. The invention also relates to antimicrobial compositions that include a microbial biofilm formation inhibiting amount of such substituted 2-aminoimidazoles or imidazo[1,2-a]pyrimidinium salts in combination with excipients. Methods for inhibiting or controlling microbial biofilm formation in a plant, a body part of a human or an animal, or a surface with which a human or an animal may come into contact are also disclosed.

专利号:US-7645754-B2
优先权日:2001-12-20
标题 :Pyrrolopyrimidine A2B selective antagonist compounds, their synthesis and use
发明人：CASTELHANO ARLINDO; MCKIBBEN BRYAN; STEINIG ARNO
权利人:OSI PHARM INC
摘要:The subject invention provides compounds having the structure: n n n n n n n n n n n n wherein,n R 1 is a substituted or unsubstituted alkyl, wherein the substituent is hydroxyl, dihydroxy, carboxyl, —C(â•?O)NR a R b , —NR a R b , —NR a C(â•?O)NR a R b , —NR a C(â•?O)OR a , —OC(â•?O)NR a R b , or —NHC(â•?O) R a ; R 2 is hydrogen or a substituted or unsubstituted alkyl, wherein the substituent is hydroxyl, dihydroxy, carboxyl, —C(â•?O)NR a R b , —NR a R b , —NR a C(â•?O)NR a R b , —NR a C(â•?O)OR a , —OC(â•?O)NR a R b , or —NHC(â•?O)R a , or R 1 , R 2 and N together form a substituted piperazine, substituted azetidine ring, or a pyrrolidine ring substituted with —(CH 2 ) 2 OH or —CH 2 C(â•?O)OH; R 3 is a substituted or unsubstituted phenyl or a 5-6 membered heteroaryl ring, wherein the substituent is halogen, hydroxyl, cyano, (C 1 -C 15 )alkyl, (C 1 -C 15 )alkoxy, or —NR a R b ; R 4 is hydrogen or substituted or unsubstituted (C 1 -C 15 )alkyl; R 5 is —(CH 2 ) m OR 6 , —CHNOR 7 , —C(â•?O)NR 8 R 9 , —(CH 2 ) m C(â•?O)OR 10 , —(CH 2 ) k C(â•?O)NR 11 R 12 ;n wherein R 6 is a substituted or unsubstituted (C 1 -C 30 )alkyl, (C 3 -C 10 )cycloalkyl, or an aryl, heteroaryl or 4-8 membered heterocyclic ring; R 7 is hydrogen, or a substituted or unsubstituted (C 1 -C 30 )alkyl, (C 1 -C 30 )alkylaryl; R 8 and R 9 are each independently hydrogen, or a substituted or unsubstituted (C 1 -C 30 )alkyl, (C 1 -C 30 )alkylaryl, (C 1 -C 30 )alkylamino, (C 1 -C 30 )alkoxy, or a saturated or unsaturated, monocyclic or bicyclic, carbocyclic or heterocyclic ring, or R 8 , N, and R 9 together form a substituted or unsubstituted 4-8 membered heterocyclic ring; R 10 is hydrogen or a substituted or unsubstituted (C 1 -C 30 )alkyl, (C 3 -C 10 )cycloalkyl, or an aryl, heteroaryl or heterocyclic ring; R 11 , N and R 12 together form a 4-8 membered heterocyclic ring; R a and R b are each independently hydrogen or alkyl; m is 0, 1, 2 or 3; and k is 1, 2 or 3,n nor a specific enantiomer thereof, or a specific tautomer thereof, or a pharmaceutically acceptable salt thereof, and a method for treating a disease associated with the A 2b adenosine receptor in a sbject in need of such treatment comprising administering to the subject a therapeutically effective amount of the compounds of the invention.

专利号:CN-109232343-A
优先权日:2018-10-24
标 题 :A method for copper-catalyzed synthesis of aromatic/alkane 2,2,2-trifluoroethyl selenide and its application in pesticides

专利号:US-3076033-A
优先权日:1949-12-17
标 题 :Synthesis of aldehydes
发明人：LESTER FRIEDMAN
权利人:JACOB T BASSECHES

专利号:CN-109232343-B
优先权日:2018-10-24
标 题:A method for copper-catalyzed synthesis of aromatic/alkane 2,2,2-trifluoroethyl selenide and its application in pesticides

专利号:US-7109220-B2
优先权日:2003-11-19
标 题:Amino substituted pyridinyl methanone compounds useful in treating kinase disorders
发明人：LIN RONGHUI; WETTER STEVEN K; LU YANHUA; CONNOLLY PETER J; EMANUEL STUART; GRUNINGER ROBERT H; MIDDLETON STEVEN A
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention provides amino substituted pyridinyl methanone compounds; pharmaceutical compositions comprising the compounds and methods of synthesis thereof. The compounds, which are cyclin dependent kinase (CDK) inhibitors, can be used to treat or ameliorate CDK mediated disorders. The invention thus also provides the therapeutic or prophylactic use of the compounds and/or pharmaceutical compositions to treat such disorders.