CAS: 42014-51-7; 2,5-Dioxopyrrolidin-1-Yl 2-Bromoacetate

相似化合物

14464-29-0 27243-15-8 39028-27-8

上下游产品

CAS号6066-82-6 N-羟基琥珀酰亚胺 | CAS号79-08-3 溴乙酸 | CAS号538-75-0 N,N'-二环己基碳酰亚胺 | CAS号598-21-0 溴乙酰溴 | CAS号607-71-6 4-甲基香豆素 | CAS号27667-34-1 4-甲氧基-2-喹啉酮 | CAS号19063-55-9 6-溴-2H-苯并吡喃-2-酮 | CAS号865817-83-0 6-氯-4-甲氧基喹啉-2-醇 | CAS号90834-19-8 4-(2-phenylethe...

📜N-羟基丁二酰亚胺,溴乙酰溴置于吡啶体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 溴乙酸 N-羟基琥珀酰亚胺酯
参考文献:2-S-磷酸酯的水解和氨解动力学研究和预测.
标题:2-S-磷酸酯的水解和氨解动力学研究和预测.
摘要:背景:异双功能交联剂可用于蛋白质科学和有机合成.水性体系中反应性酯的氨解通常用于生物共轭化学,但它必须与水解过程竞争.在这里,我们研究了 2-S-磷酸乙酸酯中间体的氨解和水解动力学,这些中间体是由常用的溴乙酸酯交联剂中的硫代磷酸酯亲核试剂取代溴化物引起的.结果:我们发现使用 N-羟基苯并三唑和 N-羟基琥珀酰亚胺溴乙酸盐在尿苷-5'-单硫代磷酸酯和 D-氨基葡萄糖之间的交联是无效的.为了深入了解这些不足,2-S-(5'-硫代磷酰尿苷)乙酸酯是使用溴乙酸对硝基苯酯或溴乙酸间硝基苯酯与尿苷-5'-单硫代磷酸酯组合制备的.所得对和间硝基苯基 2-S-(5'-硫代磷酰尿苷) 乙酸酯的水解和氨解动力学通过分光光度法监测酚盐离子的形成作为 Ph 的函数来确定.尽管其硝基苯酚离去基团的 Pk(Ah) 值存在显着差异,但对和间硝基苯基 2-S-(5'-硫代磷酰尿苷) 乙酸酯显示出相似的反应性曲线.与它们
DOI:10.3762/bjoc.6.87

专利信息

专利号:US-5571677-A
优先权日:1993-07-02
标题:Convergent synthesis of branched and multiply connected macromomolecular structures
发明人：GRYAZNOV SERGEI M
权利人:LYNX THERAPEUTICS INC
摘要:The invention provides methods and compositons for convergent synthesis of branched polymers useful as molecular probes. The invention also includes several novel branched polymeric structures particularly useful for detecting target polynucleotides. Branched polymers of the invention comprise at least two branches: at least one branch is a target binding moiety capable of specifically binding to a target molecule of interest and one or more branches are signal generation moities capable of directly or indirectly generating a detectable signal. In accordance with the method of the invention branched polymers are assembled from components having phosphorothioate groups and/or haloacyl- or haloalkylamino groups. The phosphorothioate and haloacyl- or haloalkylamino groups react rapidly and efficiently when brought into contact to form thiophosphorylacyl- or thiophosphorylalkylamino bridges which.complete the assembly of a branched polymer. The method of the invention permits thorough purification and isolation of the components prior to final assembly. Incomplete branched polymers are readily separated from the desired product by standard means. The method of the invention permits the synthesis of several novel branched polymer configurations.

专利号:US-5830658-A
优先权日:1995-05-31
标 题 :Convergent synthesis of branched and multiply connected macromolecular structures
发明人：GRYAZNOV SERGEI M
权利人:LYNX THERAPEUTICS INC
摘要:The invention provides methods and compositons for convergent synthesis of branched polymers useful as molecular probes. The invention also includes several novel branched polymeric structures particularly useful for detecting target polynucleotides. Branched polymers of the invention comprise at least two branches: at least one branch is a target binding moiety capable of specifically binding to a target molecule of interest and one or more branches are signal generation moities capable of directly or indirectly generating a detectable signal. In accordance with the method of the invention branched polymers are assembled from components having phosphorothioate groups and/or haloacyl- or haloalkylamino groups. The phosphorothioate and haloacyl- or haloalkylamino groups react rapidly and efficiently when brought into contact to form thiophosphorylacyl- or thiophosphorylalkylamino bridges which complete the assembly of a branched polymer. The method of the invention permits thorough purification and isolation of the components prior to final assembly. Incomplete branched polymers are readily separated from the desired product by standard means. The method of the invention permits the synthesis of several novel branched polymer configurations.

专利号:US-6180777-B1
优先权日:1996-01-12
标 题 :Synthesis of branched nucleic acids
发明人：HORN THOMAS
权利人:BAYER AG
摘要:Branched polymers and multiply connected macromolecular structures are provided, wherein the polymers and structures are provided, wherein the polymers are structures comprise at least two branches and/or macrocycles, at least one of which is a target binding moiety capable of binding to a target molecule of interest, and at least another of which is a signal generation moiety capable of directly or indirectly generating a signal. These polymers and structures contain components that are linked through sulfur-containing bridges that are selectively cleaved by oxidation, e.g. thiophosphorylacyl, dithiophosphorylacyl, thiophosphorylthio, thiophosphorylalkylamino and/or dithiophosphorylalkylamino bridges, Synthetic methods are also provided, as are kits containing a complexing buffer and a nucleic acid probe composed of the branched polymer or macromolecular structure.

专利号:US-8410028-B2
优先权日:2003-12-17
标 题:Methods for synthesis of encoded libraries
发明人：MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

专利号:US-5635157-A
优先权日:1992-04-13
标 题 :Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging
发明人：MEASE RONNIE C; KOLSKY KATHRYN L; MAUSNER LEONARD F; SRIVASTAVA SURESH C
摘要:Cyclohexyl chelating agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N, N, N', N'-tetra acetic acid.

专利号:US-5648218-A
优先权日:1993-02-12
标 题 :Preparation of photoprotein conjugates and methods of use thereof
发明人：STULTS NANCY L
权利人:SEALITE SCIENCES INC
摘要:The present invention encompasses a method of synthesis of conjugates of photoproteins that retain all or a substantial portion of the luminescent activity of underivatized photoprotein. According to the present invention photoproteins may be conjugated with a variety of binding reagents including streptavidin/avidin, glycoproteins, lectins, hormones, antigens, drugs, antibodies and antigen binding fragments thereof, or any other selectively bindable reagent by chemical crosslinking means. The present invention also encompasses conjugates produced by this method, and methods of use of such conjugates.