CAS: 42013-20-7; 2-(2-Methylbenzamido)Acetic Acid

该化合物是流行酸的一种衍生物,其特点是在苯环的2位置上增加了一个甲基组,这种改变增强了其物理化学特性,使其在分析化学和代谢研究中有用.该化合物是发现和量化生物样本中相关代谢物的宝贵参考标准,其稳定性和定义明确的结构有利于精确的色谱分析,特别是在HPLC和LC-MS应用中.此外,2-甲基乙基甲基丙酸用于研究尿尿生物标志和新陈代谢,其一贯的纯度和可靠性能使它成为需要高质量标准的实验室和工业应用的首选.

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物理性质

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CAS号933-88-0 邻甲基苯甲酰氯 | CAS号56-40-6 甘氨酸 | CAS号78973-74-7 N-o-toluoyl-gly... | CAS号118-90-1 邻甲基苯甲酸

合成工艺路线路线简述

    📜邻甲基苯甲酰氯置于水,碳酸氢钠,Sodium Hydroxide体系中,用 2-甲基四氢呋喃,水 作为反应溶剂,化学反应 4.5H,反应生成 2-甲基马尿酸
    参考文献:Substituents Effect On The Erlenmeyer−plöchl Reaction: Understanding An Observed Process Reaction Time
    标题:Substituents Effect On The Erlenmeyer−plöchl Reaction: Understanding An Observed Process Reaction Time
    摘要:A Systematic Study On Hippuric Acid Substituents Was Performed In Order To Better Understand The Influence Of Stereoelectronic Factors On The Erlenmeyer Reaction Rate. In Addition,Two Reaction Systems Were Evaluated: Hunig'S Base Solvent Free Conditions And Catalytic Sodium Acetate In 2-Methyl-Thf. The Effect On Reaction Rate Of Electron Withdrawing And Electron Donating Groups Are Reported. Specifically,The Study Led To The Conclusion That Stereoelectronic Factors Have Significant Influence In One Of Our Key Erlenmeyer Reaction By Affecting Its Reaction Rate.
    DOI:10.1021/op100032S

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    专利信息


    专利号:US-9217012-B2
    优先权日:2009-04-08
    标题 :Inhibitors of protein tyrosine phosphatases
    发明人：ZHANG ZHONG-YIN; ZHANG SHENG
    权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
    摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

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    主要参考文献

    [参考文献]: Remane D, Et Al. Validation Of A Multi-Analyte Hplc-Dad Method For Determination Of Uric Acid, Creatinine, Homovanillic Acid, Niacinamide, Hippuric Acid, Indole-3-Acetic Acid And 2-Methylhippuric Acid In Human Urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Aug 15;998-999:40-4.
    [参考文献]: C Lacroix, Et Al. [参考文献]: J Chromatogr. 1986 Oct 31:382:275-9.
    [参考文献]: H Matsui, Et Al. High-Performance Liquid Chromatographic Separation Of Urinary Hippuric And O-, M- And P-Methylhippuric Acids With A Beta-Cyclodextrin-Bonded Column. J Chromatogr. 1989 Nov 10;496(1):189-93.
    [参考文献]: I Lundberg, Et Al. Correlation Of Xylene Exposure And Methyl Hippuric Acid Excretion In Urine Among Paint Industry Workers. Scand J Work Environ Health. 1986 Apr;12(2):149-53.
    [参考文献]: K J Lee, Et Al. Application Of Micellar Electrokinetic Capillary Chromatography For Monitoring Of Hippuric And Methylhippuric Acid In Human Urine. Electrophoresis. 1994 Jan;15(1):98-102.

    合成参考文献


    摘要:S50 | CCSCOMPEND | The Unified Collision Cross Section (CCS) Compendium | DOI:10.5281/zenodo.2658162
    摘要:https://pubs.rsc.org/en/content/articlelanding/2017/sc/c7sc03464d
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