CAS: 41879-39-4; O-(Tert-Butyldimethylsilyl)Hydroxylamine

相似化合物

18173-64-3 66548-21-8 1028432-04-3

上下游产品

tert-butyldimethylsilyl chloride(E)-trans-2-methoxy-3-methylcyclohexanone O-(tert-butyldimethylsilyl)oxime (E)-cis-4-tert-Butyl-2-chlor°Cyclohexan-1-one (tert-butyldimethylsilyl)oxime 18H34ClNO2SiC18H34ClNO2Si 19H36ClNO2SiC19H36ClNO2Si

叔丁基二甲基氯硅烷置于盐酸羟胺,乙二胺体系中,用 二氯甲烷 作为反应溶剂,化学反应 96.0H,以69%的收率获得产物o-(叔丁基二甲基硅烷)羟胺
参考文献:New C-3' Hydroxamate-Substituted And More Lipophilic Cyclic Hydroxamate Cephalosporin Derivatives As A Potential New Generation Of Selective Antimicrobial Agents
标题:New C-3' Hydroxamate-Substituted And More Lipophilic Cyclic Hydroxamate Cephalosporin Derivatives As A Potential New Generation Of Selective Antimicrobial Agents
摘要:描述了一系列新的c-3'羟肟酸取代的头孢菌素衍生物的合成,这些衍生物具有强大的抗菌活性和介质依赖的抗结核活性.
DOI:10.1039/b612475E

专利信息

专利号:US-6281245-B1
优先权日:1996-10-28
标 题:Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
发明人：PATEL DINESH V; NGU KHEHYONG
权利人:VERSICOR INC
摘要:A novel method for generating hydroxylamine, hydroxamic acid, hydroxyurea, and hydroxylsulfonamide compounds is disclosed. The method involves the nucleophilic attack of an alkoxyamine on a suitable solid phase support. Techniques of combinatorial chemistry can then be applied to the immobilized alkoxyamine to generate a diverse set of compounds. Cleavage of the compounds from the support yields a library of hydroxylamine or hydroxylamine derivative compounds, which can be screened for biological activity (e.g., inhibition of metalloproteinases).

专利号:US-6541276-B2
优先权日:1996-10-28
标题:Methods for solid-phase synthesis of hydroxylamine compounds and derivatives and combinatorial libraries thereof
发明人：PATEL DINESH V; NGU KHEHYONG
权利人:VERSICOR INC
摘要:A novel method for generating hydroxylamine, hydroxamic acid, hydroxyurea, and hydroxylsulfonamide compounds is disclosed. The method involves the nucleophilic attack of an alkoxyamine on a suitable solid phase support. Techniques of combinatorial chemistry can then be applied to the immobilized alkoxyamine to generate a diverse set of compounds. Cleavage of the compounds from the support yields a library of hydroxylamine or hydroxylamine derivative compounds, which can be screened for biological activity (e.g., inhibition of metalloproteases).

专利号:WO-9935126-A1
优先权日:1998-01-09
标 题 :Solid supported synthesis of hydroxamic acids
发明人：GOLEBIOWSKI ADAM; KLOPFENSTEIN SEAN REES
权利人:PROCTER & GAMBLE; GOLEBIOWSKI ADAM; KLOPFENSTEIN SEAN REES
摘要:The subject invention involves processes for making hydroxamic acid compounds using a solid-support resin having an oxime moiety as the linking moiety of the resin, comprising the steps of (a) treating the resin with a carboxylic acid compound, such that it is attached to the resin by a condensation reaction between the oxime and carboxyl moieties; (b) optionally modifying the side chain; (c) cleaving a product from the resin by treating with O-tert-butyldimethylsilylhydroxylamine; (d) optionally modifying the side chain; and (e) optionally treating the resulting O-TBS-protected material with acid to produce an unprotected hydroxamic acid compound.

专利号:US-6291709-B1
优先权日:1998-12-28
标题:Solid supported synthesis of hydroxamic acids
发明人：GOLEBIOWSKI ADAM; KLOPFENSTEIN SEAN REES
权利人:PROCTER & GAMBLE
摘要:The subject invention involves processes for making hydroxamic acid compounds using a solid-support resin having an oxime moiety as the linking moiety of the resin, comprising the steps of (a) treating the resin with a carboxylic acid compound, such that it is attached to the resin by a condensation reaction between the oxime and carboxyl moieties; (b) optionally modifying the side chain; (c) cleaving a product from the resin by treating with O-tert-butyldimethylsilylhydroxylamine; (d) optionally modifying the side chain; and (e) optionally treating the resulting O-TBS-protected material with acid to produce an unprotected hydroxamic acid compound.

专利号:US-8231858-B2
优先权日:2003-02-10
标 题 :Diagnostic imaging agents with MMP inhibitory activity
发明人：STOREY ANTHONY; DAVIS JULIE; RICKETTS SALLY-ANN; MENDIZABAL MARIVI; CUTHBERTSON ALAN; ARUKWE JOSEPH; HEYWOOD KIRSTY; WILSON IAN; WYNN DUNCAN; SCHAFERS MICHAEL; LEVKAU BODO; WAGNER STEFAN; BREYHOLZ HANS-JOERG; KOPKA KLAUS
权利人:STOREY ANTHONY; DAVIS JULIE; RICKETTS SALLY-ANN; MENDIZABAL MARIVI; CUTHBERTSON ALAN; ARUKWE JOSEPH; HEYWOOD KIRSTY; WILSON IAN; WYNN DUNCAN; SCHAFERS MICHAEL; LEVKAU BODO; WAGNER STEFAN; BREYHOLZ HANS-JOERG; KOPKA KLAUS; GE HEALTHCARE LTD
摘要:The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.

专利号:WO-9818754-A1
优先权日:1996-10-28
标 题:Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof