CAS: 402-69-7; 6-Fluoropyridine-2-Carboxylic Acid

相似化合物

3939-15-9 208110-81-0 455-71-0

上下游产品

2-fluoro-6-methylpyridine 2-Amino-6-methylpyridine 2-fluoro-5-methylpyridine water methyl 6-fluoropyridine-2-carboxylate 2-fluoro-6-hydroxymethylpyridine 6-fluoropyridine-2-carboxamide 6-fluoropyridine-2-carbonyl chloride

2-氨基-6-甲基吡啶置于potassium Permanganate,Tetrafluoroboric Acid,Sodium Nitrite体系中,用 水 作为反应溶剂,化学反应生成 2-氟吡啶-6-羧酸
参考文献:Synthesis Of Some Fluorine-Containing Pyridinealdoximes Of Potential Use For The Treatment Of Organophosphorus Nerve-Agent Poisoning
标题:Synthesis Of Some Fluorine-Containing Pyridinealdoximes Of Potential Use For The Treatment Of Organophosphorus Nerve-Agent Poisoning
摘要:Fluoroheterocyclic Aldoximes Were Screened As Therapeutic Agents For The Treatment Of Anticholinesterase Poisoning. 2-Fluoropyridine-3-And-6-Aldoxime,And 3-Fluoropyridine-2-And-4-Aldoxime,Were Synthesised. Attempts To Obtain 3,5,6-Trifluoropyridine-2,4-Bis(Aldoxime) And-2-Aldoxime,However,Proved Unsuccessful. Pentafluorobenzaldoxime Was Prepared By Oximation Of Pentafluorobenzaldehyde. Acid Dissociation Constants (Pk(A)) And Second-Order Rate Constants (K(Ox)-) Of The Fluorinated Pyridinealdoximes Towards Satin Were Measured. 2,3,5,6-Tetrafluoropyridine-4-Aldoxime Had The Best Profile: Its K(Ox)-Approached That Of The Therapeutic Oxime P2S (310 Vs. 120 L Mol(-1) Min(-1)),But Its Higher Pk(A) (9.1 Vs. 7.8) Fell Short Of The Target Figure Of 8 Required For Reactivation Of Inhibited Acetylcholinesterase In Vivo. N-Alkylation Of The Fluorinated Pyridine-Aldoximes May Reduce Their Pk(A) Nearer To 8 And Enhance Their Therapeutic Potential. Crown Copyright (C) 2011 Published By Elsevier B.V. All Rights Reserved.
DOI:10.1016/j.Jfluchem.2011.05.028

专利信息

专利号:CN-104003934-B
优先权日:2014-06-13
标题:Synthesis of 6-chloro-3-fluoro-2-pyridinecarboxylic acid

专利号:CN-112194687-A
优先权日:2020-11-12
标题:A kind of metal nickel complex with ether bond bridged bispyridine carboxylic acid as ligand and its synthesis method and photocatalytic application