CAS: 2746-25-0; 1-(Bromomethyl)-4-Methoxybenzene

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CAS号105-13-5 对甲氧基苄醇 | CAS号631-61-8 乙酸铵 | CAS号123-11-5 4-甲氧基苯甲醛; 对甲氧基苯... | CAS号104-93-8 4-甲基苯甲醚(MSO) | CAS号18494-82-1 2-[(4-methoxyph... | CAS号14629-56-2 (4-Methoxybenzy... | CAS号92565-78-1 4-ch3°C6h4ch2omom | CAS号106-44-5 对甲酚 | CAS号824-94-2 4-甲氧基苄氯 | CAS号112089-06-2 9-[(4-methoxyph... | CAS号112088-77-4 6-chloro-9-(4-m... | CAS号112088-76-3 6-chloro-9-[(4-... | CAS号105192-33-4 6-[(4-methoxyph... | CAS号102831-36-7 6-(4-methoxyphe... | CAS号103-87-7 alpha-dimethyla... | CAS号3168-59-0 2-甲基-5-甲氧基苯甲酸 | CAS号3462-97-3 (4-甲氧基苄基)三苯基氯化膦 | CAS号3694-57-3 4-甲氧基苄基异硫氰酸酯

对甲苯甲醚置于n-溴代丁二酰亚胺(Nbs)体系中,用 四氯化碳 用作溶剂,化学反应 2.0H,反应生成4-甲氧基溴苄
参考文献:无金属条件下甲基芳烃一锅法转化为芳香醛
标题:无金属条件下甲基芳烃一锅法转化为芳香醛
摘要:在通过用 N-甲基吗啉 N-氧化物处理将苄基溴转化为相应的芳香醛的研究的基础上,在 Aibn 的存在下,在回流的乙腈中用 Dbdmh 或用 Nbs 处理各种甲基芳烃ccl4置于30 oc 下用钨灯照射(方法 B),然后用 N-甲基吗啉 N-氧化物处理以提供高产率的芳香醛.这些方法可用于在无毒性较小的试剂和过渡金属的条件下将甲基芳烃一锅法转化为芳香醛.
Doi:10.1002/ejoc.201402015

专利信息

专利号:WO-2021014395-A1
优先权日:2019-07-24
标题:Process for the synthesis of deuterated capsaicin, capsaicinoids and synthetic capsaicin analogs
发明人：ORUGANTI SRINIVAS; AMRUTAPU SRAVANTH KUMAR; SAMPATH MAGESH; SEN SAIKAT
权利人:DR REDDY’S INST OF LIFE SCIENCES
摘要:The present application provides novel processes for the synthesis of deuterated intermediates of capsaicinoids, particularly II, III, IV and V of capsaicinoids, relating to pharmaceutical applications. The invention also provides novel intermediates of compounds of formula IX, XIV, XV, XVI, XVII, XVIII, XX and XXI utilized in the process of making deuterated capsaicin II, III, IV and V.

专利号:US-2004018598-A1
优先权日:2000-05-30
标题 :Bio-intermediates for use in the chemical synthesis of polyketides
发明人：SANTI DANIEL; ASHLEY GARY; MYLES DAVID C
摘要:The present invention relates to compounds made by a subset of modules from one or more polyketide synthase (“PKSâ€?) genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring polyketides or derivatives thereof. The biologically derived intermediates (“bio-intermediatesâ€?) generally represent particularly difficult compounds to synthesize using traditional chemical approaches due to one or more stereocenters. In one aspect of the invention, an intermediate in the synthesis of epothilone is provided that feeds into the synthetic protocol of Danishefsky and co-workers. In another aspect of the invention, intermediates in the synthesis of discodermolide are provided that feed into the synthetic protocol of Smith and co-workers. By taking advantage of the inherent stereochemical specificity of biological processes, the syntheses of key intermediates and thus the overall syntheses of compounds like epothilone and discodermolide are greaty simplified.

专利号:US-9556140-B2
优先权日:2013-01-26
标 题 :Approach for synthesis of catechins
发明人：DUGAR SUNDEEP; MAHAJAN DINESH; RAI KUMAR SANTOSH; TRIPATHI VINAYAK; PATIL ISHWAR RAKESH
权利人:SPHAERA PHARMA PRIVATE LTD
摘要:A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+ and/or −) epicatechin and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (−)-epicatechin; (vi) optionally simultaneously deprotecting and by drogenation of the compound obtained from step (ii) to obtain racemic epicatechin.

专利号:US-6455680-B1
优先权日:2000-12-21
标 题 :Methods utilizing aryl thioimines in synthesis of erythromycin derivatives
发明人：LUKIN KIRILL A
权利人:ABBOTT LAB
摘要:An efficient deoximation technique for use in synthesis of erythromycin derivatives, involving aryl thioimine intermediates is disclosed. The aryl thioimine intermediates can be utilized in a method for protecting a ketone of a ketone-containing erythromycin derivative as a thioimine; a method for deoximating an oxime-containing erythromycin derivative, or a method for preparing a 6-O-alkyl erythromycin derivative. Presently preferred erythromycin derivatives have a C-9 oxime or a C-9 ketone.

专利号:WO-2020255049-A1
优先权日:2019-06-20
标题:Process for the preparation and identification of deuterated eugenol
发明人：ORUGANTI SRINIVAS; AMRUTAPU SRAVANTH KUMAR; SAMPATH MAGESH; SEN SAIKAT
权利人:DR REDDY’S INST OF LIFE SCIENCES
摘要:The present invention provides a novel, simple, unique and viable processes for the synthesis of deuterium incorporated eugenols, such as deuterated eugenol (II), regioisomeric deuterated eugenol (III), and deuterated variant of methyl eugenol (V).

专利号:US-8987430-B2
优先权日:2009-10-30
标 题:Efficient and scalable process for the manufacture of fondaparinux sodium
发明人：PATEL PAYAL PARTH; MA CHUN; OHRR KEVIN K; NADJI SOURENA
权利人:PATEL PAYAL PARTH; MA CHUN; OHRR KEVIN K; NADJI SOURENA; RELIABLE BIOPHARMACEUTICAL CORP
摘要:The present invention relates to a process for the synthesis of the Factor Xa anticoagulent Fondaparinux and related compounds. The invention relates, in addition, to efficient and scalable processes for the synthesis of various intermediates useful in the synthesis of Fondaparinux and related compounds.