CAS: 274-79-3; Imidazo[1,2-A]Pyrazine

相似化合物

912773-24-1 76537-23-0 2385057-35-0

上下游产品

2-Aminopyrazine 2-chloroethanal Bromoacetaldehyde diethyl acetal 1-bromo-2,2-dimethoxyethanepyrazine8-phenylimidazo1,2-apyrazine pyrazine3,5-dibromoimidazo1,2-apyrazine pyrazine5-bromoimidazo1,2-apyrazine pyrazine3-bromoimidazo1,2-apyrazine

3-(1-羟乙基)咪唑并[1,2-A]吡嗪 反应生成吲哚[1,2-A]吡嗪
参考文献:Lumma,W. C.,,Jr;Springer,J. P.,J. Org. Chem.,1981,46,N 18,3735-3736
标题:Lumma,W. C.,,Jr;Springer,J. P.,J. Org. Chem.,1981,46,N 18,3735-3736

专利信息

专利号:US-11161827-B2
优先权日:2019-04-05
标 题 :Catalytic systems for stereoselective synthesis of chiral amines by enantiodivergent radical C—H amination
发明人：Zhang xiao-xiang; Lang kai
权利人:TRUSTEES BOSTON COLLEGE; THE TRUSTEES OF BOSTON COLLEGE
摘要:In one aspect, the disclosure relates to a mode of asymmetric induction in radical processes based on sequential combination of enantiodifferentiative H-atom abstraction and stereoretentive radical substitution. Also disclosed is an asymmetric system for stereoselective synthesis of strained 5-membered cyclic sulfamides via radical 1,5-C—H amination of sulfamoyl azides. The disclosed metalloradical system can control the degree and sense of asymmetric induction in the catalytic radical C—H amination in a systematic manner. The disclosed system is applicable to a broad scope of substrates with different types of C(sp 3 )—H bonds and exhibits reactivity and selectivity, providing access to both enantiomers of useful 5-membered cyclic sulfamides in a highly enantioenriched form. Also disclosed are catalysts useful in these processes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

专利号:US-11186678-B2
优先权日:2018-11-30
标 题 :Radical cascade-enabled synthesis of precision polymers with complex main-chain structures
发明人：NIU JIA; HUANG HANCHU; WANG WENQI
权利人:TRUSTEES BOSTON COLLEGE
摘要:Radical cascade reactions enabling sequence-controlled ring-closing polymerization and ring-opening polymerization for the controlled synthesis of polymers with complex main-chain structures are provided. Facile syntheses leading to low-strain macrocyclic monomers consisting of the ring-opening triggers and extended main-chain structures are also provided. The present disclosure further provides methods for excellent control over polymer molecular weights and molecular weight distributions and high chain-end fidelity allows for the preparation of polymeric systems with well-defined architectures. Further provided are the general nature of the radical cascade-triggered transformations in polymer chemistry, and its application to the synthesis of polymers with diverse main-chain structural motifs with tailored functions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

专利号:US-11912647-B2
优先权日:2020-05-22
标 题:Diversity-oriented synthesis of N,N,O-trisubstituted hydroxylamines from alcohols and amines by N—O bond formation
发明人：CRICH DAVID; HETTIKANKANAMALAGE ASIRI; HILL JARVIS
权利人:UNIV GEORGIA
摘要:In one aspect, the disclosure relates to a method for the direct synthesis of complex N,N,O-trisubstituted hydroxylamines by N—O bond formation. In another aspect, the method can successfully be employed using a wide variety of commercially available alcohols and secondary amines and enables the construction of large fragment-based libraries of trisubstituted hydroxylamines for drug discovery purposes. Also disclosed are N,N,O-trisubstituted hydroxylamines having low basicity, high stability at ambient temperatures, and an inherent lack of reactivity towards acetylating and sulfonylating enzymes that confer mutagenicity on less-substituted hydroxylamines.

专利号:US-9936723-B2
优先权日:2014-02-12
标题 :Process for the synthesis of substituted 1-benzyl-3-(1-(isoxazol-4-ylmethyl)-1h-pyrazol-4-yl)imidazolidine-2,4-diones
发明人：FOTSING JOSEPH R
权利人:SENOMYX INC
摘要:The present invention relates to processes and intermediates for the preparation of compounds of formula (I): n nor a salt or oxide thereof, wherein Alk, M1, M2, R1, R2, R3, R4, R5, R6, R7, and n are as described herein. The present invention also relates to compounds of formula (I) and composition comprising a compound of formula (I). Also disclosed is a method of altering or improving the taste of a composition that includes adding to the composition at least one compound of formula (I), in an amount effective to obtain a modified composition having altered or improved taste relative to an otherwise identical composition lacking said compound.

专利号:US-2023285442-A1
优先权日:2020-03-26
标题 :Use of oligochitosans and derivatives thereof for neutralizing viral agents
发明人：MOHAPATRA SUBHRA; MOHAPATRA SHYAM S; Garay Julio; HANNA MAZEN; MAYILSAMY KARTHICK
权利人:MOHAPATRA SUBHRA; MOHAPATRA SHYAM S; Garay Julio; HANNA MAZEN; MAYILSAMY KARTHICK
摘要:Described herein are methods for neutralizing a virus. The methods involve interacting the virus with an oligochitosan or a derivative thereof having a molecular weight of at least 1 KDa and a degree of deacetylation of at least 1%. The methods described herein have numems applications with respect to the treatment or prevention of viral infections caused by a human immunodeficiency virus, a paramyxovirus, an orthomyxovirus, a coronavirus, or a filovirus as well as the detection and quantification of viral load. Also described herein are the synthesis of the oligochitosan and derivatives thereof.

专利号:US-11117123-B2
优先权日:2019-04-16
标 题:Compositions and methods for catalysts based on bridged chiral amidoporphyrins and their metal complexes
发明人：Zhang xiao-xiang; HU YANG
权利人:TRUSTEES BOSTON COLLEGE; THE TRUSTEES OF BOSTON COLLEGE
摘要:In one aspect, the disclosure relates to a mode of asymmetric induction in radical processes based on enhanced hydrogen-bonding capability and the situation of metal centers in cavity-like chiral environments. Also disclosed is an asymmetric system for stereoselective synthesis of cyclopropane and aziridine derivatives. The disclosed Co(II)-based metalloradical system has been shown to have an unusual capability of controlling both the degree and sense of asymmetric induction in cyclopropanation and aziridination reactions in a systematic manner. The disclosed system is applicable to a broad scope of substrates having diazo or azido moieties and exhibits a remarkable profile of reactivity and selectivity, providing access to cyclopropane diastereomers and aziridine enantiomers in highly enantioenriched forms. Also disclosed are catalysts useful in the disclosed processes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.