CAS: 26156-48-9; Methyl 2-Bromoisonicotinate

相似化合物

118289-16-0 118289-17-1 66572-56-3

上下游产品

diazomethane 2-bromoisonicotinic acid methanol methyl iodide 2-bromoisonicotinic acid hydrazide 2-bromoisonicotinic acid methyl ester N-oxide (2-bromopyridin-4-yl)methanol 2-(2-bromopyridin-4-yl)-propan-2-ol

2-溴-4-甲基吡啶置于potassium Dichromate,硫酸,盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺体系中,用 二氯甲烷 用作溶剂,化学反应 2.0H,反应生成2-溴吡啶-4-甲酸甲酯
参考文献:N1-Pyrazolospiroketone Acetyl-Coa Carboxylase Inhibitors
标题:N1-Pyrazolospiroketone Acetyl-Coa Carboxylase Inhibitors
摘要:该发明提供了化合物i的化合物或其药用可接受的盐,其中r1,R2,R3和r4如本文所述;以及其药物组合物;以及在治疗受乙酰辅酶a羧化酶抑制调节的动物疾病,症状或紊乱中的使用.

专利信息

专利号:WO-2023203374-A1
优先权日:2022-04-20
标 题 :[1,2]selenazolo[2,3-a]pyridin-8-ium inhibitors of pyruvate kinase isoform m2
发明人：ARSENJANS PAVELS; DIMITRIJEVS PAVELS; MAKRECKA-KUKA MARINA
权利人:LATVIAN INST ORGANIC SYNTHESIS
摘要:The present invention relates to a novel isoselenazolopyridinium salts as anticancer agents by inhibiting pyruvate kinase isoform M2 (PKM2) activity, as well as methods of their manufacturing and use in different pharmaceutical compositions for the treatment of various diseases and disorders by administration of such substances.

专利号:US-2010004245-A1
优先权日:2006-10-20
标 题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：OBALLA RENATA M; DESCHENES DENIS; GAGNON MARC; LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-11739065-B2
优先权日:2016-06-13
标题 :FXR (NR1H4) modulating compounds
发明人：BLOMGREN PETER A; CURRIE KEVIN S; GEGE CHRISTIAN; KROPF JEFFREY E; XU JIANJUN
权利人:GILEAD SCIENCES INC
摘要:The present disclosure relates generally to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.